CONSTIPATION ON BABIES : HOW DO U MAKE A BABY : WOMENS FAT BABY BOOTS.
Thalidomide Definition Thalidomide, which is also known as Thalomid, is a drug used to fight aggressive cancers, particularly those that have metastasized, or spread. Purpose There are many studies, either in progress or recently completed, that suggest thalidomide can slow or stop the spread of cancer of the brain, breast, colon and prostate, as well as multiple myeloma (a cancer of the marrow of the bone). Research studies that consider the benefit of thalidomide in treating other cancers are multiplying rapidly. The use of the drug in cancer therapy is likely to increase. Description Thalidomide was first introduced in 1957 primarily as a tranquilizer, a medication prescribed particularly for imparting drowsiness and sleep. Then, it was given to pregnant women to provide them with relief from morning sickness. Soon after being prescribed to pregnant women, thalidomide was linked to death or severe disabilities in newborns. Some children who had been exposed to thalidomide while in the womb (in utero) failed to develop limbs or had very short limbs. Others were born blind or deaf or with other physical problems. The same action of thalidomide that harms babies, may make it useful as a powerful cancer fighter. Thalidomide interferes with the formation of blood vessels. It is called an antiangiogenic drug because angiogenesis refers to the formation of blood vessels. Cancers that spread have a lot of blood vessels (are highly vascularized). Thus, when cancer cells are not nourished by a blood supply, they die. One way to stop the spread of cancer is to stop the formation of the blood vessels that carry nourishment to the cancer cells, and that is what thalidomide is thought to do. (Researchers are also interested in other activities of thalidomide, particularly the ones that make it capable of eliminating skin eruptions, such as sores, or ulcers, in the mouths of patients with AIDS and leprosy.) Recommended dosage Dosages being used depend on the type of cancer being attacked. For example, in one study, to treat multiple myeloma, a starting dose of 200 milligrams per day was increased to 800 milligrams per day over a two-week period. In a colon cancer study, 400 milligrams per day of thalidomide were given in combination with the anti-cancer drug irinotecan . The dose of irinotecan was between 300 and 350 milligrams per day. Used in combination with irinotecan, thalidomide contributed its own cancer-fighting properties and it also seemed to reduce the side effects of irinotecan. In a trial using thalidomide to treat prostate cancer , both low doses (as low as 200 milligrams per day) and high doses (as high as 1200 milligrams per day) were tried. The patients taking high doses fared somewhat better. Precautions The serious threat thalidomide poses to fetuses cannot be overstated. No pregnant woman and no woman who has any chance of becoming pregnant should take thalidomide. (Only women who have had a hysterectomy or who are at the age of menopause and have been in a menopausal state, which is no menses, or periods, for 24 consecutive months, can be considered as having no chance of becoming pregnant.) Patients taking thalidomide must meet strict criteria for use. Pharmacies that dispense thalidomide must have special registration. Side effects Besides the extreme risk thalidomide poses to fetuses, it also produces side effects in the person taking the drug. The side effects of thalidomide are much milder than many other anticancer drugs, and because the drug poses less discomfort than other cancer-fighting drugs, it is particularly attractive to oncologists, or physicians who treat cancer patients. Among the side effects are erratic heartbeat, swelling (edema), digestive upsets of all sorts, including both constipation and diarrhea , pain in muscles in the back and neck, and skin problems. Interactions Both barbiturates, salts and esters used to encourage sleep, and alcohol increase the effect of thalidomide's power of sedation. They should not be taken with the drug. Food interferes with the absorption of thalidomide, and it should be taken when the stomach is empty. Diane M. Calabrese KEY TERMS Angiogenesis —The process by which tumors gain access to a blood supply, allowing tumor growth. Fetus —Human embryo. Kilogram —Metric measure that equals 2.2 pounds. Milligram —One-thousandth of a gram, and there are one thousand grams in a kilogram. A gram is the metric measure that equals about 0.035 ounces.Day Thirty
It's Friday. Brandi totally took this picture of us sleeping just before she went to work in the morning. I half heard her sneak in and click the camera but in that way where you don't really wake up. I knew she did it but didn't want to wake up enough to be all awake. The baby did seem to notice a little bit so Brandi snuck out again. She seemed quite a bit better today in terms of her crabbiness. She also pooped four times. I think the prune juice I added to her cereal helped her out and perhaps the constipation was the root of her grumblecake eatingness. She wasn't too hungry first thing in the morning, she only ate like maybe 3 ice cubes of apples before turning away when I gave her the spoon. I threw it in the fridge for her lunch later. We headed out to the aquarium in the later but it was really packed full of people. I suspect it's the newness of the baby beluga that sent people flocking there. We just did a quick circuit of the other things and then left since we didn't want to wait in the giant beluga line up. Lunch time added some squash to the apples and fed it to her. She usually likes to sit in her chair and play with her spoon a little after eating but today she wanted out almost right away. I took her out and let her play on the floor but soon realised she's getting much more adventurous with her newfound crawling ability. I had to block off the kitchen and the front hallway with stuff (buggy, vibrate-y chair, backpack) so that she couldn't get by. She was also crawling under the computer table where I had to retrieve her before she played with cords. I was also all stern with her and said "No" a bunch of times where she didn't cry and try and make me feel bad. I put her down for a nap around 1:30 and she basically slept until Brandi got home at 3. She did wake up briefly once or twice and go "wa" and then back to sleep. I was impressed. However when I did get her and take her into the living room where there was a bottle waiting (which she didn't know about) she did do her squinchy-working-up-to-a-good-cry face and then started screaming really loudly. Until I was all "Here's your bottle" at which point she stopped. Brandi got home but she was too engrossed with her bottle to really do anything. She did get a little kicky when she was finally able to see her but nothing like normal. We went out for a walk to the sandwich place and picked up some more raw fruit and veg for us to prep for her to eat and headed home. We gave her some cottage cheese with her dinner today and I'm not sure it agreed with her, she was pretty pukey after the fact much to Brandi's shoulders disappointment. We then broke our armour trying to kill Ignis and Kolgarn trash in Ulduar before finally giving up and going back to Naxx for a wing clearage with our lower geared characters. Once that broke we did 10 person Ulduar. Still no loots for me. Oh well, I got a couple on Tues so it's all good.
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