attempts to explore the R2R3 MYBs in Arabidopsis using current Bioinformatics tools. 

Gene-specific regulation of transcription is of fundamental importance for virtually every aspect of cellular functions. Specificity is provided by the action of transcription factors, modular proteins typically composed of a DNA binding domains and effector domains responsible for activator or repressor activity. The formation of these complexes involves the combinatorial action of transcription factors that bind conserved promoter elements in precise spatial orientation and on the basis of both specific protein–DNA and protein–protein interactions.

MYB proteins are common to all eukaryotes. However, in higher plants this protein family is extraordinarily amplified.Plant MYB proteins are known to be involved in a variety of cellular processes including the regulation of biosynthetic pathways like phenylpropanoid or tryptophan biosynthesis, control of cell fate determination and regulation of the cell cycle. 

Furthermore, functions as diverse as the more structural role of telomere binding MYB proteins, the involvement in circadian clock-regulated gene expression and a regulatory role in the phosphate starvation response have been described

According to the type of their DNA binding domain, transcription factors can be assigned to different families. MYB proteins constitute a diverse class of DNA-binding proteins of particular importance in transcriptional regulation in plants. The two-repeat (R2R3) MYB family is the largest family characterised in plants. Members are characterised by having a structurally conserved DNA-binding domain, the MYB domain. Although functional similarities exist between R2R3 MYB proteins that are closely related structurally, there are significant differences in the ways very similar proteins function in different species and also within the same organism

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