CURRICULUM  VITAE
Name                               :   DR. ANTHONY MELVIN CRASTO
Date of Birth                    :   17th January, 1964
Nationality                      :   Indian  
Sex                                    :   Male (Married)
Email: amcrasto@gmail.com
Residence. Tel                :+91-9323115463

EDUCATIONAL QUALIFICATIONS :

Degree

Institution Conferring

Year

Class (%)

   Ph.D.

(Organic

Chemistry)        

Department of Chemical

Technology, Matunga,

Bombay (Univ. of Bombay) India

Thesis: Synthesis of Novel Pyrethroid Analogues

1991

By Research

Prof. S. Seshadri)

 

 

 

   M.Sc.

(Organic

Chemistry)

 R.J.college,   Ghatkopar,

 Bombay (Univ. of Bombay)

 India

1986

   First

 (65.50%)

 

   B.Sc.

Chemistry

 R.J.college,   Ghatkopar,

 Bombay (Univ. of Bombay)

1984

   First

 (62.60%)

   H.Sc.

 R.J.college,   Ghatkopar,

 Bombay (Poona Board)

1981

   First

 (68.17%)

   S.S.C.

 St. Xavier`s high School,

 Powai, Bombay (Poona  Board)

1979

   First

 (69.29%)

 PGDIAC

 Ruia College, Matunga,

 Bombay (Autonomous)

1987

 Grade A

   DBM

 L.N. Welingkar Institute of

 Management, R & Development.

1990

 Grade A

 

JOB PROFILE: To carry out research and development activity in the field of Organic Chemistry to make profit for the organisation, motivate, guide & lead a team of scientists, conduct literature search, identify and execute new/novel routes for the synthesis, scale up from grams to kilo levels in lab., conduct pilot trials and assist in production upto ton levels. Carry out impurity profiles and assist in dossier writing. All the above being done keeping in mind the regulatory, safety, environmental issues. To keep in mind IPR issues and draft patents ,Commercial aspects taken care are the time schedules, quality parameters and cost factors. All this with a view of non infringement and confidentiality. Simultaneously develop business acumen and convert to profits.to file dmfs in US/EU. To file patents and develop noninfringing routes

 

EXPERIENCE:  (academic  1987-1991,  4years) (Industry   1991-present,  21 years)   total=25+ yrs

 

1      Worked as Indian Organic chemicals research fellow at UDCT Matunga, Mumbai, INDIA for PhD programme(organic chemistry) on the topic “ Synthesis of novel pyrethroids analogues”. Simultaneously did  project work for IOC.(1987-1991, 4 years)

 

2      Carried out Synthetic Research work as a Management trainee (R&D) at an American multinational Searle India ltd, Research and development centre, Thane, India (Now RPG Life Sciences Ltd) (May 1991 to Dec.  1992, 1 year 7 months)

 

3     Worked as an Executive at a German multinational  Hoechst Marion Roussel Ltd, Mulund, Mumbai, India in the Process Development Team. (Jan1993 - Jan1997, 4 years)

 

4     Worked as an Executive at Hoechst Marion Roussel Ltd, Mulund, Mumbai, India in the QA dept, GMP section (Feb.1997 – oct. 1997, 8 months)

 

5        worked as a Manager (R&D) at RPG Life Sciences Ltd ( formerly Searle). Thane Belapur. INDIA  The job involved all aspects of synthesis and commercialization from research lab to production, including third party activities. (Oct. 1997- may2003, 5 years 6 months )

 

6        worked as Sr Manager R&D with Innovassynth technologies Limited, khopoli, INDIA (formerly IOC ltd) and led a team of 20 chemists for the custom synthesis business in the area of drugs, organic intermediates, speciality chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.(may03-dec05----2 yrs 7 months)

 

7        Currently working with GLENMARK PHARMACEUTICALS LTD research centre as  principal scientist in API division at Mahape ,Navi Mumbai,(dec05-present) job involves research and development work on APIs for DMF filing, develop novel routes and file patents

 

 

RESEARCH ACTIVITIES COVERED IN THE ENTIRE CAREER

 

1) Extensive range of chemistry and scale of manufacture from laboratory, scale up laboratory, pilot plant, plant scale including third party activity.

 

2)    Applied intellectual and synthetic skills to the process development of pharmaceutical drugs/their intermediates, and natural products, neutraceuticals, mettalocenes, speciality chemicals, flavours and fragrances in the laboratory and monitor them during plant trials.

 

3)    Act as a technology transfer man and provide all data required for transfer from lab to commercialization.

 

4)    Assist in stability studies/impurity profiles/dossiers and act as a coordinator between lab and commercial production. Also required to synthesize some impurities in pure form to meet the dossier demands.

 

5)    Complete command for use of computer, ability to use all programs( word,excel,powerpoint) and no need for secretarial assistance.

 

6)    Use of Internet and manual literature search methods to decide the synthetic strategy and upgrading of literature information for existing entities. Well versed with CAS scifinder program for literature search. Also having the ability to look for free information on the web( patents, etc). well versed with use of a german program for lit search ie spresiweb,ability to handle programs like integrity etc

 

7)    Use of modern spectroscopy/analytical methods to monitor the synthetic scheme.

 

8)    Guide a team of chemist/technologists during commercialization.

 

9)    Use of GLP/GMP wherever required i.e. lab, pilot plant, plant and maintain documentation as per norms applicable.

 

10) Assist the technologist during unit operations during manufacture.

 

11)  Strictly follow the safety norms, educate and implement the safety   

            Procedure as per norms, conduct hazop studies.

 

12)  Training and development of fresh chemists and up-gradation of skills of 

existing ones, Maintain a cogenial atmosphere for the team and                encourage team work.

 

13)  Finally  look  for  excellent  standards of working, which will minimize

       reworks / cost and maximize output.

 

14) Excellent ability to understand and communicate to foreign customers via email, documents and telephone. Maintain good documentation in this respect. Excellent presentation skills for presenting to top management or clients

15) Ability to work with original inventor in US and the drug company needing the final product in Europe, eg coenzyme q10 . Interact with both of them and produce results acceptable to both.

 

16) Maintain confidentiality and stick to the agreement.

 

17) Write DHR for API before implementation of novel route in the plant and assist  for all  batches for the DMF purposes, very well versed with IPR issues

 

18) Ability to develop novel routes for API,s and draft patents,well  versed with polymorphism issues.several patents filed in US/EU

 http://surfip.ipexl.com/directory/en/inventor/Anthony_Melvin_Crasto_1.html

 

HIGHLIGHTS:

 

Worked with reputed Organic Scientists in the Chemical Industry, some have worked with Nobel laureates like Sir. Derek  Barton, Dr. H. C. Brown and Prof. M.S. Newmann.

 

1)

Dr. K. Nagarajan 

:

Ex. Research Director Ciba &   Searle

 

2)

Dr. (Prof) S. Seshadri

:

Research guide (UDCT), worked with Nobel laureate. M. S. Newmann

 

3)

Dr. S. J. Shenoy

:

Ex. Ciba / Searle Scientist

 

4)

Dr. J. R. Patell

:

HMR, 25 yrs. Industry Exp.

 

5)

Dr. B.K. Kulkarni

:

HMR, now IOC (director. R&D) 25 yrs Industry Exp.

 

+6)

Dr. T. V. Radhakrishnan

:

RPG. (V.P.R&D) worked with nobel laureate  Sir Derek Barton

 

7)     

Dr. Ralph  Stapel

:

(German gentleman) Hoechst Marion Roussel(HMR) , Agrevo Technical Director

 

8)

Dr. P. Menesse

:

G.M. (GMP HMR)

 

9)

Dr. K. R. Ramachandran

:

G.M. Technical (Isagro Asia Ltd.)

 

10)

Dr. Khandelwal

:

G.M. Regional Quality Operations, HMR

 

 

 

 

 

 

1.    Awarded Rs.20000/- 1992 for best performance in Hoechst Marion Roussel(HMR),MUMBAI,INDIA.

2.    Involved in a successful TGA Audit in HMR 1997

3.    Promoted to Executive from Officer in HMR (1996)

4.    Exported 100Kg. MAPO (RPG) 1998  to CBZ U.K. in 3 months time and later awarded a trip to U.K.

5.    Promoted from Asst. Manager to Manager (RPG 2000) for commercialization of 25 tons deltamethrin (product instrumental in a gain of 90 crores from sale to isagro limited)

6.    Manufactured Raloxifene (2 kg.) in a team work in one months time to be registered in U.K. for CBZ  U.K.

7.    Registered Donepezil for the 1st time in India and later on manufactured 4 kg. (2002-03)

8.     involved at Innovassynth  in commercialization of a dozen projects to the tune of a turnover of 60 crores in the custom synthesis business for reputed foreign clients

9.    At Innovassynth contributed 2 products in the first year, guggulsterone and BTE which led to construction of a pilot plant worth 22 crores.

10. stock options:allotted 70,000 shares of innovassynth under key employee stock option

11. Attended international organic chemistry conference in Singapore on 8 dec 2005-10 dec 2005

12. Filed several patents.LIST AVAILABLE ON REQUEST

           

 

PROJECTS  HANDLED  AT  SEARLE  INDIA  LIMITED(American multinational)   (May 1991 to Dec.  1992, 1 year 7 months)

(Drugs and Natural products )

 

1)

Azathioprine

:

Partially worked on all the steps without having much exposure on the project.

2)

Cis – Menthadienol

:

In a team worked on a 6 step stereospecific synthesis.

3)

Trans- Menthadienol

:

In a team isolated it from Ginger grass oil in its pure form.

4)

Olivetol

:

In a team worked on its 3 step   synthesis.

5)

Iothalamic acid

:

In a team worked on its process development.

6)

Diatrizoic acid

:

In a team worked on its process development.

7)

Iopamidol

:

In a team worked on its process development.

 

RESEARCH GROUP :

 

Worked with Dr.K. Nagarajan and Dr. (Mrs.) S.J. Shenoy

________________________________________________________________

EXPERIENCE AT GERMAN MULTINATIONAL HOECHST MARION ROUSSEL LTD. (MULUND, MUMBAI). (Jan1993 - Jan1997, 4 years)

 

PROJECTS HANDLED:

1.

 

Pentoxyfylline

:

Independently developed a new route

2.

Roxatidine

:

In a team worked on some of its intermediates 

 

 

 

 

3.

Deltamethrin

:

Process development and production trouble Shooting

4.

 

ECPPA

:

Independently developed a 5 step route for the             

synthesis of this single isomer (Enalapril/Ramipri

Intermediate)

5.

Furamethrin Alc

:

Independently developed a commercially viable

route for its manufacture involving Acetylene as

the raw material.

6.

Tefuramethrin

:

Independently developed its synthesis for M/S

Diannihon Jochugiko Japan.

7.

 

Several Drugs/ Vet.Drugs

:

Trouble shooting for production (eg. Pitofenone

HCl, Frusemide, Ramipril, etc.)     

 

EXPERIENCE WITH GMP/QA DEPT. IN HOECHST MARION ROUSSEL LIMITED (1997 Feb to Oct. 1997—8 MONTHS)

 

QUALITY ASSURANCE/GOOD MANUFACTURING PRACTICES

 

1.

Exposure to GMP in Bulk drugs and Formulations

2.

Excellent Computer literacy.

3

Prepared Drug master files and Site master files for submission to Foreign

and  Local regulatory bodies.

4.

Conducted Process validations of Bulk drugs.

5.

Exposure to cleaning validations.

6.

Reviewing of SOP's for different departments.

7.

Reviewing of MFR's and BMR's

8.

All aspects of documentation with respect to GMP guidelines.

9.

Involved in a successful preparation for an audit  by the Australian

regulatory  body." Therapeutic Goods Administration (TGA) "

10.

Similar involvement with a WHO audit of formulations

11.

Conducted several GMP audits.

12

Conducted several Vendor assessments.

 

MANUFACTURING

Practical  Production training in Pharmaceutical manufacturing in the following Departments.

1. Powder injectibles

2. Large Volume Parenterals (Haemaccel)

3. Small Volume Parenterals (Liquid injectibles)

4. Tablets.

 

PROJECTS HANDLED AT RPG Life sciences ltd (formerly American multinational SEARLE INDIA  LIMITED,  1997-2003)

(Drugs, Drug intermediates,Agrochemicals, intermediates for custom synthesis)

 

  

1)

Deltamethrin

:

Manufactured  3 tonnes on plant scale as R & D demonstration at an commercially viable cost, the process was developed from scratch ie  lit,lab work, scale-up, pilot trials and also included third party work. Later on annually about 25 tonnes were manufactured.

2)

Acetamiprid

:

Developed a process from scratch. Process was handed over to isagro  for commercialization in 2001 during hiving of the company from RPG

 

3)

M-alcohol an intermediate of  Tetra conazole

:

During isagro transition period in 2001, the process from Italy was adapted to Indian plant conditions, scaled up with some modification and handed over for commercialization. This is being produced on a regular basis.

4)

Pyrazosulfuron ethyl

:

Developed a process from scratch. Process was handed over to isagro  for commercialization in 2001 during hiving of the company from RPG

 

 

 

 

pharmaceuticals

1)

Donepezil

:

Manufactured  4 kilos on pilot plant scale as R & D demonstration, the process was developed from scratch. Plans are to make 25 kilos with 300% profit margins

 

2)

Pantoprazole

:

Process is being modified continuously to cope-up  with price crash

 

3)

PZL Chloride an intermediate of  Pantoprazole

:

Multi step process is being continuously modified / developed to meet cost demands

 

4)

Cilostazole

:

Under development

 

5)

Gatifloxacin

:

Developed a process which was not commercialized due to cheap drug available from china.

 

6)

Raloxifene

 

Was involved in the scale up team supporting rapid commercialization of the drug

7)

 Chiral Piperazine

 

 Developed this intermediate of Indinavir

8)

Int. of Glimepiride

 

Developed 3 – ethyl – 4 methyl – 3- pyrrolin – 2 - one

                                             

 

INTERMEDIATES (custom synthesis)

 

1)

Thiol intermediate of raloxifene

:

Manufactured  2 kilos on pilot plant scale as R& D demonstration( for CBZ . UK)

2)

TPCP

:

Manufactured 1 kilo in lab ( Aventis Germany)

4-Phenyl-4-Piperidine carboxylic acid tosylate (TPCP)

3)

DBAP

:

Manufactured 0.250 kilo in lab( Aventis Germany)

Ethyl-3-(N-(3,4 Dimethoxybenzyl)amino propionate

4)

MAPO

:

Methyl aziridine phoshonium oxide,100 kg in pilot plant (CBZ.  U.K.)

 

5)

6 HDHQ Int of cilostazole

:

Manufactured 0.250 kilo in lab ( Davos, USA)

 

 

6)

p-Trifluoromethyl benzonitrile

 

Manufactured 1 kg for Rhodia,France

7)

6-MDHQ

 

Manufactured 0.5 kg for Davos

 

 

Experience at Innovassynth techologies limited

a custom synthesis company catering to leading American and European multinationals (may2003_ dec05, 2 yrs 7 months)

Headed a group  and worked on approx 25 custom synthesis projects with 18 scientists/chemists and 2 literature scientists.

 

Dozen projects already executed and some in pipeline waiting for commercialization in the old and new pilot plants.

( clients include Bedoukain, CCR, polyfine, Novartis, lonza, Synergy, BASF, Austin,  FMC, Crompton, Semafore etc)

projects commercialized

1                    Guggulsterone

2                    COENZYME Q10 Intermediate

3                    N-(2,4 Dimethoxy phenyl) piperazine

4                    2,6 -DMPI

5                    Benzoic acid 4(4-propyl-1- piperazine)

6                    2,4- dichloro 5- methoxyaniline

7                    2- bromo hexanoic acid

8                    CCTI

9                    DMCPA.HCl

10                Hexyl resorcinol

11                Several in pipeline for commercialization

12                60 samples sent for evaluation to foreign clients

 

 

Experience at GLENMARK GENERICS LTD, Research Centre,(dec05-present)

 

Currently working as principal scientist and leading a team of scientists in developing APIs for regulated markets, this involves novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis and commercialization and assist in providing support for DMF filing.

Currently involved in development of SEVERAL targets for regulated markets. The job involves visualization of novel routes and its execution , simultaneously develop intellectual property and generate data in the process,. Provide support to US/European marketing team for developing and  execution of new projects

 

 

 

WORKSHOP ATTENDED

1.            Attended  workshop cum Course on SYNTHESIS OF ORGANIC CHEMICALS held on Feb. 1991 at University Department of Chemical Technology, Matunga – Bombay

 

2.            Attended MANAGERIAL EXCELLENCE a 3 day workshop at HOECHST MARION ROUSSEL LTD(Mulund,Mumbai), Bombay organized by Baroda Productivity Council, Baroda.

 

PUBLICATIONS:

 

  1. A .M. Crasto and S. Seshadri

Heterocyclic Analogues of Pyrethroids)Paper presented at the Thirteenth    International Congress of Heterocyclic Chemistry held at Corvallis, Oregon (U.S.A.) fromAug. 11th – 16th, 1991.  Abstract No. GE-11-129 (Paper presented by Prof.S. Seshadri.

 

    2.     A.M. Crasto  N. H.  Mehta and S. Seshadri

Novel Pyrethroid Analogues Paper presented at Annual Conference 1989) of the Indian Council of Chemists held at Tirupati.  Abstract No. 00 – 35

 

    3.     A. M. Crasto and  S. Seshadri

Synthesis of Novel & Chloromethyl esters via Regiospecific  ring opening reactions of aryl glycidyl ethers with acid chlorides and the synthesis of alpha-  morpholino methyl and  alpha-  cyano methyl esters. Paper presented at the 3rd Research Scholars Meeting, Indian Chemical Society, Feb. 1991.  Abstract No.

 

4           SEVERAL PATENTS FILED

PAGE CREATED BY DR ANTHONY MELVIN CRASTO M.SC, PH.D (ORGANIC CHEMISTRY,25+ years experience in the field of research and development

NAME: DR. ANTHONY MELVIN CRASTO. 

Principal scientist, GLENMARK-GENERICS LTD

Navi mumbai, INDIA

Email  amcrasto@gmail.com

 

MOBILE+91-9323115463
TWITTER-   @amcrasto





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Your Publications

  • Title:AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF

    Authors: A M CRASTO

    Ref. No: US 20100310870

    Year: 2010

    "The present invention relates to amorphous form of bazedoxifene acetate and a process for the preparation thereof."

  • A PROCESS FOR THE PREPARATION OF ATOVAQUONE CRYSTALLINE

    Authors: A M CRASTO ET AL

    Ref. No: 1742/MUM/2007 A

    Year: 2009

    "The present invention provides a process for the preparation of Atovaquone in a pure polymorphic form characterized by an X-ray powder diffraction pattern with peaks at about 7.0, 9.7, 14.2,..."

  • Process for the preparation of tadalafil

    Authors: A M CRASTO

    Ref. No: EP2004644 (A1)

    Year: 2008


  • Process for the preparation of atovaquone

    Authors: A M CRASTO

    Ref. No: US20090105350

    Year: 2008


  • Amorphous eprosartan mesylate and process for the preparation thereof

    Authors: A M CRASTO

    Ref. No: United States Patent Application 20080014263

    Year: 2007


  • PROCESS FOR THE PREPARATION OF TADALAFIL

    Authors: A.M. CRASTO

    Year: 2007


  • A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4-DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE

    Authors: A M CRASTO ET AL

    Ref. No: Application No.243/BOM/1999 A

    Year: 1999

    "A process for the preparation of methanamine-N-[4(3,4-dichlorophenyl)]-3,4-dihydro-1(2H)-naphthalenylidene, a critical intermediate in the synthesis of cis-(1S,4S)-4-(3,4-dichlorophenyl)-1,..."

  • Heterocyclic Analogues of Pyrethroids

    Authors: A .M. Crasto and S. Seshadri

    Thirteenth International Congress of Heterocyclic Chemistry , held at Corvallis, Oregon (U.S.A.) Abstract No. GE-11-129 ; 1991

    Thirteenth International Congress of Heterocyclic Chemistry , held at Corvallis, Oregon (U.S.A.) Abstract No. GE-11-129 ; 1991


  • SYNTHESIS OF NOVEL PYRETHROID ANALOGUES

    Authors: A.M. CRASTO

    MUMBAI UNIVERSITY, 1991

    Supervisor: PROF S . SESHADRI


  • Synthesis of Novel & Chloromethyl esters via Regiospecific ring opening reactions of aryl glycidyl ethers with acid chlorides and the synthesis of alpha- morpholino methyl and alpha- cyano methyl esters

    Authors: A. M. Crasto and S. Seshadri

    Paper presented at the 3rd Research Scholars Meeting, Indian Chemical Society, Feb. 1991. , TIRUPATI, INDIA; 1988

    Paper presented at the 3rd Research Scholars Meeting, Indian Chemical Society, Feb. 1991. , TIRUPATI, INDIA; 1988



    cccc

    Anthony Melvin Crasto Ph.D

    Anthony Melvin Crasto Ph.D

    PRINCIPAL SCIENTIST, at Glenmark-Generics Ltd,Navi Mumbai,India, founder of Linkedin group Organic Process Development

    Thane, Maharashtra, India (Mumbai Area, India) 
    Pharmaceuticals

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    Anthony Melvin Crasto Ph.D's Overview

    Current
    Past
    • Principal scientist, GLENMARK PHARMACEUTICALS LTD research centreat Glenmark Pharmaceuticals
    • Sr Manager R&D or Group principal scientist at Innovassynth
    • Manager, research and development, API,RPG Life sciences ltd (formerly American multinational SEARLE at RPG Life Sciences

    see all

    Education
    • INSTITUTE OF CHEMICAL TECHNOLOGY (UDCT)
    • R.J.college, Ghatkopar, Bombay (Univ. of Bombay)
    • R .J.college, Ghatkopar, Bombay (Univ. of Bombay)

    see all

    Recommendations

    5 people have recommended Anthony Melvin

    Connections

    500+ connections

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    Anthony Melvin Crasto Ph.D's Summary

    Ph.D,Org Chem,ICT, Mumbai,India, amcrasto@gmail.com,9323115463, 25+ years in industry( API), mostly multinationals, process development in companies like Hoechst Marion Roussel(Sanofi aventis), Searle, RPG, Innovassynth, Glenmark, with exposure to basic research at SEARLE under Dr Nagarajan (Director Ciba), Tech transfer in plant eg deltamethrin 3 tonnes in RPG, bulk drug gmp (7 months) in Hoechst Marion Roussel(SANOFI AVENTIS), Custom syn in Innovasynth(SANDOZ, Basel, BASF Germany), exposure to natural pdts, drugs int, vet drugs, and some exposure in agro.speciality chemicals, flavours and fragrances, nutraceuticals and mettalocenes. ability to deliver products in the prodn plant(atleast 35 in career).
    highlights
    1. Felt proud to spend millenium night (2000) in plant
    2. Added personally a 25 kg sodium cyanide charge in a reactor at 2 in night, panoli, RPG.in 90'decade, not to be attempted again
    3. Did not run away and controlled an exotherm in plant batch due to accidental addn of acid.Cl into NaCN rxn 
    4. Sim. case when a thin film high vac distn exploded in a pilot plant in nasik for CBZ chem. UK, still able to despatch 100 kg material, Award london trip
    5. High vac. distilled 25 kg of drug int in the night using 3 pumps for a pilot plant trial intermediate, SANDOZ Basel, award bottle of wine from switzerland
    6. Personally worked after lab work in evenings with Dr Ralph Stapel , director. in modern, Hoechst pilot plant at Mulund Mumbai, in 80'
    7. Assisted Head Asia pacific, QA for TGA audit at Aventis plant ankleshwar
    8 Slept for 3 hrs in morning in first aid room in Panoli during Deltamethrin process demo at panoli Gujarat, then afternoon 2 hrs at guest house during 6 months campaign
    9 Reached Innovasynth lab in khopoli at 9 morning from mumbai,100 km, using trucks, ricks after july monsoon deluge in Mumbai 2005
    10 Got an opportunity to write a DMF in 90', hoechst, Got a chance to work in tablets,large vol parenterals, inj, vaccines in Hoechst mulund plant

    Specialties

    To carry out research and devpt, motivate, guide & lead a team of scientists,conduct lit.search,identify and execute new/novel routes for the synth,scale up from grams to kg levels in lab,conduct pilot trials/assist in prodn.upto ton levels. Carry out impurity profiles and assist in dossier writing. To keep in mind IPR issues and draft patents, file DMFS in US/EU, file patents and contribute to intellectual property,Ability to develop novel routes for API,s, well versed with polymorphism issues

    Anthony Melvin Crasto Ph.D's Experience

    Principal Scientist, Process research

    Glenmark Generics Ltd.

    Privately Held; 1001-5000 employees; glenmark; Pharmaceuticals industry

    December 2005 – Present (7 years 1 month) Mahape, Navimumbai, India, email me, amcrasto@gmail.com, 09323115463, call now

    Currently working with GLENMARK GENERICS LTD research centre as Principal Scientist, process research (bulk actives) at Mahape ,Navi Mumbai,and leading a team of scientists in developing APIs for regulated markets, this involves visualization and execution of novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis in lab and commercialization on plant , support for DMF filing.
    Currently, involved in development of several targets for regulated markets. Provide support to US/European marketing team for developing and execution of new projects
    Process Development :-
    • Providing guidance and support for process development for challenging of patents in regulated market.
    • Design patent non-infringing scalable synthetic routes/process and scale-up of API’s
    • Bench and Pilot scale synthesis transformations in hands on
    • Optimization of the process, ie,developing industrially feasible process.
    • Preparation of PDR, filing of patent and DMF
    • Lead a group of Scientists and Group Leaders(for docs). 
    Skill sets:- Technical skills:
    Synthesis:
    • Development of novel synthetic routes/process for pharmaceuticals and successful implementation of the technology in pilot plant
    • Conducted various reactions at laboratory and production scales. 
    • Synthesized various classes of compounds. 
    • Experienced to work under cGMP condition
    Documentation: 
    • Literature survey: well conversant with the use of Sci Finder and Internet search techniques.
    • Operating Instruction: Preparation of scale up report (process, yield, costing, quality, specification etc.).
    • Setting of specifications: Supported analytical section for method development and establishment of specification for Raw Material, Intermediate and finished products. 
    Soft skills:-
    • Creativity in problem solving, Highly motivated and Self-starting individual, Excellent communication skill,Team leader with good listening

    EX Hoechst Marion Roussel(SANOFI AVENTIS), RPG Life Sciences,Innovassynth, SEARLE,AGREVO,IOC

    Glenmark Generics Ltd.

    Privately Held; 1001-5000 employees; glenmark; Pharmaceuticals industry

    December 2005 – Present (7 years 1 month) email me, amcrasto@gmail.com, 09323115463, call now

    joined Glenmark with allround experience described in this profile, EMAIL, amcrasto@gmail.com, 09323115463 call now

    Principal scientist, GLENMARK PHARMACEUTICALS LTD research centre

    Glenmark Pharmaceuticals

    Public Company; 5001-10,000 employees; GLENMARK; Pharmaceuticals industry

    December 2005 – June 2007 (1 year 7 months) MAHAPE, INDIA, email me, amcrasto@gmail.com, 09323115463, call now

    RESEARCH ACTIVITIES COVERED IN THE ENTIRE CAREER
    1) Extensive range of chemistry and scale of manufacture from laboratory, scale up laboratory, pilot plant, plant scale including third party activity.

    Applied intellectual and synthetic skills to the process development of pharmaceutical drugs/their intermediates, and natural products, neutraceuticals, mettalocenes, speciality chemicals, flavours and fragrances in the laboratory and monitor them during plant trials.

    Act as a technology transfer man and provide all data required for transfer from lab to commercialization.

    Use of Internet and manual literature search methods to decide on non infringing route

    Write DHR for API before implementation of novel route in the plant and assist for all batches for the DMF purposes, very well versed with IPR issues 

    Ability to develop novel routes for API,s and draft patents,well versed with polymorphism issues.several patents filed in US/EU
    total exp23+ in industry, Currently working as principal scientist and leading a team of scientists in developing APIs for regulated markets, this involves novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis and commercialization and assist in providing support for DMF filing.
    Currently involved in development of several targets for regulated markets. The job involves visualization of novel routes and its execution , simultaneously develop intellectual property and generate data in the process,. Provide support to US/European marketing team for developing and execution of new projects

    Sr Manager R&D or Group principal scientist

    Innovassynth

    May 2003 – November 2005 (2 years 7 months) KHOPOLI, MH, INDIA, email me, amcrasto@gmail.com, 09323115463, call now

    led a team of 30 chemists for the custom synthesis business in the area of drugs, organic intermediates, speciality chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.customers were Sandoz Basel, BASF Germany, EMAIL, amcrasto@gmail.com, 09323115463 call now

    Manager, research and development, API,RPG Life sciences ltd (formerly American multinational SEARLE

    RPG Life Sciences

    Public Company; 1001-5000 employees; Pharmaceuticals industry

    October 1997 – May 2003 (5 years 8 months) PAWNE, MH, INDIA, email me, amcrasto@gmail.com, 09323115463, call now

    1 Donepezil : Manufactured 4 kilos on pilot plant scale as R & D demonstration, the process was developed from scratch. Plans are to make 25 kilos with 300% profit margins
    2) Pantoprazole : Process is being modified continuously to cope-up with price crash
    3) PZL Chloride an intermediate of Pantoprazole : Multi step process is being continuously modified / developed to meet cost demands
    4) Manufactured 3 tonnes deltamethrin on plant scale as R & D demonstration at an commercially viable cost, the process was developed from scratch ie lit,lab work, scale-up, pilot trials and also included third party work for one bromination step,which needed 8 reactors. Later on annually about 25 tonnes were manufactured. later on the company was taken over by a multinational for deltamethrin. the price in market crashed to half.
    5) Acetamiprid : Developed a process from scratch. Process was handed over to isagro for commercialization in 2001 during hiving of the company from RPG
    6) M-alcohol an intermediate of Tetra conazole : During isagro transition period in 2001, the process from Italy was adapted to Indian plant conditions, scaled up with some modification and handed over for commercialization. This is being produced on a regular basis.
    7) Pyrazosulfuron ethyl : Developed a process from scratch. Process was handed over to isagro for commercialization in 2001 during hiving of the company from RPG
    MANY PROJECTS ON CUSTOM SYNTHESIS FOR CBZ, PFIZER, AVENTIS, ETC WERE DONE DURING THIS TENURE IN RPG LIFE SCIENCES

    Manager, R &D-sister concern of RPG--1 MONTH, ISAGRO INDIA PVT LTD-- AN ITALIAN MULTINATIONAL

    Isagro S.p.A.

    Privately Held; 501-1000 employees; Chemicals industry

    January 2003 – February 2003 (2 months)

    Carried out Synthetic Research work partly at (R&D) at RPG RESEARCH CENTRE NAVIMUMBAI- PLANT WAS AT PANOLI,email me, amcrasto@gmail.com, 09323115463, call now

    7 MONTHS ONLY WITH GMP/QA DEPT AND REPORTING TO GMP HEAD , ASIA PACIFIC

    HOECHST MARION ROUSSEL

    Public Company; 10,001+ employees; SNY; Pharmaceuticals industry

    April 1997 – October 1997 (7 months) MULUND, INDIA, email me, amcrasto@gmail.com, 09323115463, call now

    QUALITY ASSURANCE/GOOD MANUFACTURING PRACTICES

    1. Exposure to GMP in Bulk drugs and Formulations

    2. Excellent Computer literacy.

    3 Prepared Drug master files and Site master files for submission to Foreign
    and Local regulatory bodies.

    4. Conducted Process validations of Bulk drugs.

    5. Exposure to cleaning validations.

    6. Reviewing of SOP's for different departments.

    7. Reviewing of MFR's and BMR's

    8. All aspects of documentation with respect to GMP guidelines.

    9. Involved in a successful preparation for an audit by the Australian
    regulatory body." Therapeutic Goods Administration (TGA) "

    10. Similar involvement with a WHO audit of formulations

    11. Conducted several GMP audits.

    12 Conducted several Vendor assessments.


    MANUFACTURING
    Practical Production training in Pharmaceutical manufacturing in the following Departments.
    1. Powder injectibles

    2. Large Volume Parenterals (Haemaccel)

    3. Small Volume Parenterals (Liquid injectibles)

    4. Tablets.

    Executive BULK DRUG QA for short time at German multinational Hoechst Marion Roussel Ltd [

    HOECHST INDIA LIMITED

    April 1997 – October 1997 (7 months)

    VISITED TABLETS, LARGE VOLUME PARENTERALS, INJ, STORES ETC AS PART OF GMP TRAINING

    CUSTOM SYNTHESIS

    BASF

    Public Company; 10,001+ employees; BAS.DE; Chemicals industry

    March 1997 – May 1997 (3 months)

    CUSTOM SYNTHESIS OF API, Eg COENZYME Q10, ETC

    PROJECTS HANDLED IN CUSTOM SYN AREA

    Sandoz

    Public Company; 10,001+ employees; NVS; Pharmaceuticals industry

    March 1997 – May 1997 (3 months)

    MANY PROJECTS ON CUSTOM SYNTHESIS FOR CBZ, PFIZER, AVENTIS, ETC WERE DONE DURING THIS TENURE IN INNOVASSYNTH

    Executive process development for short timeHOECHST SCHERING AGREVO a sister concern of HMR,

    HOECHST SCHERING AGREVO

    February 1997 – May 1997 (4 months)

    PROCESS DEVELOPMENT OF AGROCHEMICALS FOR VERY SHORT TIME SINCE THIS COMPANY WAS A SISTER CONCERN OF HOECHST MARION ROUSSEL AND REPORTED TO DR RALPH STAPEL,DIRECTOR PROCESS DEVELOPMENT(ANILOPHOS, DELTAMETHRIN, TEFURAMETHRIN)

    Exec proc.development pharmaceuticals, Hoechst Marion Roussel, now Sanofi Aventis

    sanofi-aventis

    Public Company; 10,001+ employees; SNY; Pharmaceuticals industry

    January 1993 – January 1997 (4 years 1 month)

    MULUND, Mumbai. INDIA The job involved all aspects of synthesis and commercialization from research lab to production,
    PROJECTS HANDLED:
    1.Pentoxyfylline : Independently developed a new route

    2.Roxatidine : In a team worked on some of its intermediates; Process development and production trouble Shooting

    4.ECPPA : Independently developed a 5 step route for the 
    synthesis of this single isomer (Enalapril/Ramipri
    Intermediate)

    5.Furamethrin Alc : Independently developed a commercially viable route for its manufacture involving Acetylene as the raw material. 

    6.Tefuramethrin : Independently developed its synthesis for M/S
    Diannihon Jochugiko Japan.

    7. Several Drugs/ Vet.Drugs : Trouble shooting for production (eg. PitofenoneHCl, Frusemide, Ramipril, etc.)

    PROJECTS HANDLED as Management Trainee Research and devl. SEARLE INDIA LTD

    Searle

    Public Company; 10,001+ employees; Pharmaceuticals industry

    May 1991 – December 1992 (1 year 8 months) PAWNE, INDIA

    1 year 7 months)
    (Drugs and Natural products )

    1) Azathioprine :worked on all the steps. ALSO WORKED ON CANNABINOID DRUGS, OLIVETOL, worked on menthadienol, iohexol, x ray contrast agents, EMAIL, amcrasto@gmail.com, 09323115463 call now

    ORGANIC process development, INDIAN ORGANIC CHEMICALS, KHOPOLI, INDIA

    INDIAN ORGANIC CHEMICALS

    January 1987 – April 1991 (4 years 4 months)

    DID ORGANIC PROCESS DEVELOPMENT AS A RESEARCH FELLOW, email me, amcrasto@gmail.com, 09323115463, call now

    Ph. D research fellow, Organic chemistry

    Institute Of Chemical Technology

    Educational Institution; 501-1000 employees; Education Management industry

    January 1987 – April 1991 (4 years 4 months) MATUNGA, MUMBAI, INDIA,email me, amcrasto@gmail.com,09323115463

    4years
    Worked as Indian Organic; PhD programme(organic chemistry) on the topic " Synthesis of novel pyrethroids analogues". Simultaneously did project work for IOC.

    Anthony Melvin Crasto Ph.D's Publications

    • Heterocyclic Analogues of Pyrethroids

      • ACS

      A .M. Crasto, S. Seshadri
      Thirteenth International Congress of Heterocyclic Chemistry, held at Corvallis, Oregon (U.S.A.) Abstract No. GE-11-129; 01/1991

    • Synthesis of Novel & Chloromethyl esters via Regiospecific ring opening reactions of aryl glycidyl ethers with acid chlorides and the synthesis of alpha- morpholino methyl and alpha- cyano methyl esters

      • ICS

      A. M. Crasto, S. Seshadri
      Paper presented at the 3rd Research Scholars Meeting, Indian Chemical Society, Feb. 1991., TIRUPATI, INDIA; 01/1988

    Anthony Melvin Crasto Ph.D's Volunteer Experience & Causes

      • WEBSITE OWNER

        MILLION HITS ON GOOGLE
        • Education
        January 2011 – present (2 years)

        MILLION HITS ON GOOGLE ON ALL CHEMISTRY SITES, HELPING MILLIONS, ACCLAMATION WORLDWIDE

      • One lakh plus connections worldwide on all sites and counting,

        One lakh plus connections worldwide on all sites and counting,

          One lakh plus connections worldwide on all sites and counting, NETWORKING SITES TRACKER 
          on linkedin, researchgate, academia.edu, dikajob, scipeople, gplus, facebook, buzz, diigo, mashable, siliconindia, epernicus, aboutme, skillpages, viadeo, apnacircle, skilledpeople, wordpress, google gps, wix, jimdo, yolasite, bravenet, mendeley, orkut,

        • CHEM BLOG

          WIX BLOG
          • BLOG

            EUREKA MOMENTS
            • Causes I care about:

              • Animal Welfare
              • Children
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              • Health
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              • Social Services
            • Organizations I support:

              • MILLION HITS ON GOOGLE, on all chemistry websites, helping millions,
              • u r will power and determination will see u out of storm even if u r in drowning in middle of the oc

          Anthony Melvin Crasto Ph.D's Languages

          • English

             (Full professional proficiency)
          • HINDI

             (Native or bilingual proficiency)
          • MARATHI

             (Native or bilingual proficiency)
          • TULU

             (Native or bilingual proficiency)
          • GERMAN

             (Elementary proficiency)

          Anthony Melvin Crasto Ph.D's Projects

          Anthony Melvin Crasto Ph.D's Organizations

          • million hits on google

            helping millions

              u r will power and determination will see u out of storm even if u r in drowning in middle of the ocean amcrasto@gmail.com, 9323115463 email me, call now
              " I have closely brushed with death and pulled back, go out and enjoy, life is so precious ask me"
              If saturday, sunday don't excite u then change u r friends........., if monday doesn't motivate u then change u r profession............!!! 
              ...more

            Anthony Melvin Crasto Ph.D's Honors and Awards

            • MILLION HITS ON GOOGLE

              GOOGLE
              • January 2010

              Million hits on all websites, world acclamation for the same, helping millions, email me, amcrasto@gmail.com, 09323115463, call now

            • chemistry sites

              Algerian universities
              • January 2011

              appreciation of organic chemistry websites and blogs

            • chemistry blogs

              middleeast agencies
              • January 2012

              acclamation of efforts, particularly translators on blogs

            • several mails

              russian, chinese, scandinavian, brazil, universities and agencies
              • February 2012

              appreciation of efforts on net

            • Pakistan universities

              Appreciation for organic chemistry sites
              • March 2012

              Appreciation for organic chemistry sites

            • King Fahd university

              Appreciation for organic chemistry sites
              • April 2012

              Appreciation for organic chemistry sites

            • Education excellence

              UAE education agency
              • February 2011

              EFFORTS TO BRING OUT EDUCATION

            • CHINA UNIV, AND DRUG AGENCIES

              DRUG SITES
              • January 2011

              TRANSLATION METHODS

            • CANADA AYURVEDA

              CANADA AYURVEDA
              • March 2010

              CANADA AYURVEDA FOR PROMOTING IT ON WEBSITES

            • NEPAL UNIV , ADADEMIA AND GRUG AGENCIES

              CONTRIBUTION OF WEBSITES
              • May 2011

              CONTRIBUTION OF WEBSITES

            • Bangladesh academia, industry, drug agencies

              all round inf source
              • March 2011

              all round inf source on drugs

            • NIGERIA, GHANA, SUDAN, EHIOPIA, KENYA UNIV

              DRUG SITES
              • December 2010

              NIGERIA, GHANA, SUDAN, EHIOPIA, KENYA UNIV, DRUG SITES

            • Chile , mexico, bolivia, argentina drug agencies

              Chile , mexico, bolivia, argentina drug agencies
              • January 2011

              Chile , mexico, bolivia, argentina drug agencies, email me, amcrasto@gmail.com, 09323115463, call now

            • ONE LAKH CONNECTIONS PLUS ON ALL NETWORKING SITES AND STILL COUNTING

              NETWORKING SITES TRACKER

                ONE LAKH CONNECTIONS PLUS ON ALL NETWORKING SITES ,NETWORKING SITES TRACKER
                on linkedin, researchgate, academia.edu, dikajob, scipeople, gplus, facebook, buzz, diigo, mashable, siliconindia, epernicus, aboutme, skillpages, viadeo, apnacircle, skilledpeople, wordpress, google gps, wix, jimdo, yolasite, bravenet, mendeley, orkut,

              Anthony Melvin Crasto Ph.D's Certifications

              • DIPLOMA IN INDUSTRIAL AND ANALYTICAL CHEMISTRY

                • CIPLA RUIA TDM LAB
              • GENERAL ELECTRONICS

                • BOMBAY INSTITUTE OF TECHNOLOGY
              • DIPLOMA IN BUSINESS MANAGEMENT

                • WELINGKAR INSTITUTE, PODAR COLLEGE, MUMBAI
              • COMPUTER PROGRAMMING, MULUND, MUMBAI

                • EMAIL me, amcrasto@gmail.com, 09323115463 call now
              • MILLION HITS ON GOOGLE, HELPING MILLIONS

                • WORLD ACCLAMATION,email me, amcrasto@gmail.com, 09323115463, call now
              • ONE LAKH CONNECTIONS PLUS WORLDWIDE ON ALL NETWORKING SITES

                • NETWORKING SITES TRACKER

              Anthony Melvin Crasto Ph.D's Patents

              • Process for the preparation of atovaquone

                • United States Patent US20090105350
                •  
                • Issued October 9, 2008

                Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
                API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN

              • Process for the preparation of tadalafil

                • Europe Patent WO 2007110734

                Process for the preparation of tadalafil, ep also EP2004644
                Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
                API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN
                Process for the preparation of tadalafil
                PCT Application WO2007110734 
                Filed: 03/23/2007 
                Published: 10/...more

              • Amorphous eprosartan mesylate and process for the preparation thereof

                • United States Patent US20080014263

                Amorphous eprosartan mesylate and process for the preparation thereof
                Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
                API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN

              • Method for preparation of dronedarone via palladium-catalyzed hydrogenation and methanesulfonylation

                • Europe Patent WO 2012007959
                •  
                • Issued January 2012

                Method for preparation of dronedarone via palladium-catalyzed hydrogenation and methanesulfonylation WO 2012007959
                Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
                API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN

              • Method for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates

                • Europe Patent WO 2011158250
                •  
                • Issued December 22, 2011

                Method for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates ETORICOXIB
                Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
                API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN

              • Amorphous eprosartan mesylate and process for the preparation thereof

                • United States Patent US 20080014263
                •  
                • Issued January 17, 2008

                Amorphous eprosartan mesylate and process for the preparation thereof

              • AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF

                • United States Patent US 20100310870

                US 20100310870, AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF

              • A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4-DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE

                • India Patent INDIAN PAT Ref. No: Appl No.243/BOM/1999 A, Year: 01/1999
                •  
                • Issued January 1, 1999

                A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4-DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE
                Ref. No: Application No.243/BOM/1999 A, Year: 01/1999

              • IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL

                • India Patent INDIN PAT Ref. No: 1135/MUM/2006
                •  
                • Issued July 18, 2008

                Ref. No: 1135/MUM/2006 - Published: 2008-07-18 - GLENMARK PHARMACEUTICALS LIMITED, Year: 07/2008

              • A PROCESS FOR THE PREPARATION OF ATOVAQUONE CRYSTALLINE

                • India Patent Ref. No: 1742/MUM/2007 A, Year: 01/2009
                •  
                • Issued January 1, 2009

                Ref. No: 1742/MUM/2007 A, Year: 01/2009

              Anthony Melvin Crasto Ph.D's Education

              INSTITUTE OF CHEMICAL TECHNOLOGY (UDCT)

              Ph.D.ORGANIC CHEM.

              1987 – 1991

              THESIS synthesis of novel pyrethroid analogues, email me, amcrasto@gmail.com, 09323115463, call now

              Activities and Societies: Ph.D Programme,ICT, Formerly University Department of Chemical Technology, Matunga, Mumbai, India, email me, amcrasto@gmail.com, 09323115463, call now

              R.J.college, Ghatkopar, Bombay (Univ. of Bombay)

              M.Sc.Organic Chemistry

              1986

              R .J.college, Ghatkopar, Bombay (Univ. of Bombay)

              B.ScChemistry

              1984

              R.J. COLLEGE GHATKOPAR MUMBAI

              HSCSCAIENCE

              1979 – 1981

              St. Xavier`s high School, POWAI, MUMBAI

              S.S.CGENERAL

              1970 – 1979

              email me, amcrasto@gmail.com, 09323115463, call now

              Anthony Melvin Crasto Ph.D's Additional Information

              Websites:
              Interests:

              mobile, +91 9323115463, videocall, 3g no is 09920769403

              Groups and Associations:
              Honors and Awards:

              million hits on google on all sites



            ////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////


            Residence. Tel                :+91-9323115463

             CURRICULUM  VITName                               :   DR. ANTHONY MELVIN CRASTO

            Date of Birth                   :   17th January, 1964   (AGE- 44 years)

            Nationality                      :   Indian   

            Sex                                    :   Male (Married)

            Address                           :   Bldg. No-26,  Flat No.34

                                                          Vijay Nagari Annex,

                                                          Ghodbunder Rd, Thane, 400601,India.

                Email: amcrasto@gmail.com

            EDUCATIONAL QUALIFICATIONS :

            Degree

            Institution Conferring

            Year

            Class (%)

               Ph.D.

            (Organic

            Chemistry)       

            Department of Chemical

            Technology, Matunga,

            Bombay (Univ. of Bombay) India

            Thesis: Synthesis of Novel Pyrethroid Analogues

            1991

            By Research

            Prof. S. Seshadri)

             

             

             

               M.Sc.

            (Organic

            Chemistry)

             R.J.college,   Ghatkopar,

             Bombay (Univ. of Bombay)

             India

            1986

               First

             (65.50%)

             

               B.Sc.

            Chemistry

             R.J.college,   Ghatkopar,

             Bombay (Univ. of Bombay)

            1984

               First

             (62.60%)

               H.Sc.

             R.J.college,   Ghatkopar,

             Bombay (Poona Board)

            1981

               First

             (68.17%)

               S.S.C.

             St. Xavier`s high School,

             Powai, Bombay (Poona  Board)

            1979

               First

             (69.29%)

             PGDIAC

             Ruia College, Matunga,

             Bombay (Autonomous)

            1987

             Grade A

               DBM

             L.N. Welingkar Institute of

             Management, R & Development.

            1990

             Grade A

             

            JOB PROFILE: To carry out research and development activity in the field of Organic Chemistry to make profit for the organisation, motivate, guide & lead a team of scientists, conduct literature search, identify and execute new/novel routes for the synthesis, scale up from grams to kilo levels in lab., conduct pilot trials and assist in production upto ton levels. Carry out impurity profiles and assist in dossier writing. All the above being done keeping in mind the regulatory, safety, environmental issues. To keep in mind IPR issues and draft patents ,Commercial aspects taken care are the time schedules, quality parameters and cost factors. All this with a view of non infringement and confidentiality. Simultaneously develop business acumen and convert to profits.to file dmfs in US/EU. To file patents and develop noninfringing routes

             

            EXPERIENCE:  (academic  1987-1991,  4years) (Industry   1991-present,  21 years)   total=25+ yrs

             

            1      Worked as Indian Organic chemicals research fellow at UDCT Matunga, Mumbai, INDIA for PhD programme(organic chemistry) on the topic “ Synthesis of novel pyrethroids analogues”. Simultaneously did  project work for IOC.(1987-1991, 4 years)

             

            2      Carried out Synthetic Research work as a Management trainee (R&D) at an American multinational Searle India ltd, Research and development centre, Thane, India (Now RPG Life Sciences Ltd) (May 1991 to Dec.  1992, 1 year 7 months)

             

            3     Worked as an Executive at a German multinational  Hoechst Marion Roussel Ltd, Mulund, Mumbai, India in the Process Development Team. (Jan1993 - Jan1997, 4 years)

             

            4     Worked as an Executive at Hoechst Marion Roussel Ltd, Mulund, Mumbai, India in the QA dept, GMP section (Feb.1997 – oct. 1997, 8 months)

             

            5        worked as a Manager (R&D) at RPG Life Sciences Ltd ( formerly Searle). Thane Belapur. INDIA  The job involved all aspects of synthesis and commercialization from research lab to production, including third party activities. (Oct. 1997- may2003, 5 years 6 months )

             

            6        worked as Sr Manager R&D with Innovassynth technologies Limited, khopoli, INDIA (formerly IOC ltd) and led a team of 20 chemists for the custom synthesis business in the area of drugs, organic intermediates, speciality chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.(may03-dec05----2 yrs 7 months)

             

            7        Currently working with GLENMARK PHARMACEUTICALS LTD research centre as  principal scientist in API division at Mahape ,Navi Mumbai,(dec05-present) job involves research and development work on APIs for DMF filing, develop novel routes and file patents

             

             

            RESEARCH ACTIVITIES COVERED IN THE ENTIRE CAREER

             

            1) Extensive range of chemistry and scale of manufacture from laboratory, scale up laboratory, pilot plant, plant scale including third party activity.

             

            2)    Applied intellectual and synthetic skills to the process development of pharmaceutical drugs/their intermediates, and natural products, neutraceuticals, mettalocenes, speciality chemicals, flavours and fragrances in the laboratory and monitor them during plant trials.

             

            3)    Act as a technology transfer man and provide all data required for transfer from lab to commercialization.

             

            4)    Assist in stability studies/impurity profiles/dossiers and act as a coordinator between lab and commercial production. Also required to synthesize some impurities in pure form to meet the dossier demands.

             

            5)    Complete command for use of computer, ability to use all programs( word,excel,powerpoint) and no need for secretarial assistance.

             

            6)    Use of Internet and manual literature search methods to decide the synthetic strategy and upgrading of literature information for existing entities. Well versed with CAS scifinder program for literature search. Also having the ability to look for free information on the web( patents, etc). well versed with use of a german program for lit search ie spresiweb,ability to handle programs like integrity etc

             

            7)    Use of modern spectroscopy/analytical methods to monitor the synthetic scheme.

             

            8)    Guide a team of chemist/technologists during commercialization.

             

            9)    Use of GLP/GMP wherever required i.e. lab, pilot plant, plant and maintain documentation as per norms applicable.

             

            10) Assist the technologist during unit operations during manufacture.

             

            11)  Strictly follow the safety norms, educate and implement the safety   

                        Procedure as per norms, conduct hazop studies.

             

            12)  Training and development of fresh chemists and up-gradation of skills of 

            existing ones, Maintain a cogenial atmosphere for the team and                encourage team work.

             

            13)  Finally  look  for  excellent  standards of working, which will minimize

                   reworks / cost and maximize output.

             

            14) Excellent ability to understand and communicate to foreign customers via email, documents and telephone. Maintain good documentation in this respect. Excellent presentation skills for presenting to top management or clients

            15) Ability to work with original inventor in US and the drug company needing the final product in Europe, eg coenzyme q10 . Interact with both of them and produce results acceptable to both.

             

            16) Maintain confidentiality and stick to the agreement.

             

            17) Write DHR for API before implementation of novel route in the plant and assist  for all  batches for the DMF purposes, very well versed with IPR issues

             

            18) Ability to develop novel routes for API,s and draft patents,well  versed with polymorphism issues.several patents filed in US/EU

             http://surfip.ipexl.com/directory/en/inventor/Anthony_Melvin_Crasto_1.html

             

            HIGHLIGHTS:

             

            Worked with reputed Organic Scientists in the Chemical Industry, some have worked with Nobel laureates like Sir. Derek  Barton, Dr. H. C. Brown and Prof. M.S. Newmann.

             

            1)

            Dr. K. Nagarajan

            :

            Ex. Research Director Ciba & Searle

             

            2)

            Dr. (Prof) S. Seshadri

            :

            Research guide (UDCT), worked with Nobel laureate. M. S. Newmann

             

            3)

            Dr. S. J. Shenoy

            :

            Ex. Ciba / Searle Scientist

             

            4)

            Dr. J. R. Patell

            :

            HMR, 25 yrs. Industry Exp.

             

            5)

            Dr. B.K. Kulkarni

            :

            HMR, now IOC (director. R&D) 25 yrs Industry Exp.

             

            +6)

            Dr. T. V. Radhakrishnan

            :

            RPG. (V.P.R&D) worked with nobel laureate  Sir Derek Barton

             

            7)  

            Dr. Ralph  Stapel

            :

            (German gentleman) Hoechst Marion Roussel(HMR) , Agrevo Technical Director

             

            8)

            Dr. P. Menesse

            :

            G.M. (GMP HMR)

             

            9)

            Dr. K. R. Ramachandran

            :

            G.M. Technical (Isagro Asia Ltd.)

             

            10)

            Dr. Khandelwal

            :

            G.M. Regional Quality Operations, HMR

             

             

             

             

             

             

            1.    Awarded Rs.20000/- 1992 for best performance in Hoechst Marion Roussel(HMR),MUMBAI,INDIA.

            2.    Involved in a successful TGA Audit in HMR 1997

            3.    Promoted to Executive from Officer in HMR (1996)

            4.    Exported 100Kg. MAPO (RPG) 1998  to CBZ U.K. in 3 months time and later awarded a trip to U.K.

            5.    Promoted from Asst. Manager to Manager (RPG 2000) for commercialization of 25 tons deltamethrin (product instrumental in a gain of 90 crores from sale to isagro limited)

            6.    Manufactured Raloxifene (2 kg.) in a team work in one months time to be registered in U.K. for CBZ  U.K.

            7.    Registered Donepezil for the 1st time in India and later on manufactured 4 kg. (2002-03)

            8.     involved at Innovassynth  in commercialization of a dozen projects to the tune of a turnover of 60 crores in the custom synthesis business for reputed foreign clients

            9.    At Innovassynth contributed 2 products in the first year, guggulsterone and BTE which led to construction of a pilot plant worth 22 crores.

            10. stock options:allotted 70,000 shares of innovassynth under key employee stock option

            11. Attended international organic chemistry conference in Singapore on 8 dec 2005-10 dec 2005

            12. Filed several patents.LIST AVAILABLE ON REQUEST

                       

             

            PROJECTS  HANDLED  AT  SEARLE  INDIA  LIMITED(American multinational)   (May 1991 to Dec.  1992, 1 year 7 months)

            (Drugs and Natural products )

             

            1)

            Azathioprine

            :

            Partially worked on all the steps without having much exposure on the project.

            2)

            Cis – Menthadienol

            :

            In a team worked on a 6 step stereospecific synthesis.

            3)

            Trans- Menthadienol

            :

            In a team isolated it from Ginger grass oil in its pure form.

            4)

            Olivetol

            :

            In a team worked on its 3 step synthesis.

            5)

            Iothalamic acid

            :

            In a team worked on its process development.

            6)

            Diatrizoic acid

            :

            In a team worked on its process development.

            7)

            Iopamidol

            :

            In a team worked on its process development.

             

            RESEARCH GROUP :

             

            Worked with Dr.K. Nagarajan and Dr. (Mrs.) S.J. Shenoy

            ________________________________________________________________

            EXPERIENCE AT GERMAN MULTINATIONAL HOECHST MARION ROUSSEL LTD. (MULUND, MUMBAI). (Jan1993 - Jan1997, 4 years)

             

            PROJECTS HANDLED:

            1.

             

            Pentoxyfylline

            :

            Independently developed a new route

            2.

            Roxatidine

            :

            In a team worked on some of its intermediates 

             

             

             

             

            3.

            Deltamethrin

            :

            Process development and production trouble Shooting

            4.

             

            ECPPA

            :

            Independently developed a 5 step route for the            

            synthesis of this single isomer (Enalapril/Ramipri

            Intermediate)

            5.

            Furamethrin Alc

            :

            Independently developed a commercially viable

            route for its manufacture involving Acetylene as

            the raw material.

            6.

            Tefuramethrin

            :

            Independently developed its synthesis for M/S

            Diannihon Jochugiko Japan.

            7.

             

            Several Drugs/ Vet.Drugs

            :

            Trouble shooting for production (eg. Pitofenone

            HCl, Frusemide, Ramipril, etc.)    

             

            EXPERIENCE WITH GMP/QA DEPT. IN HOECHST MARION ROUSSEL LIMITED (1997 Feb to Oct. 1997—8 MONTHS)

             

            QUALITY ASSURANCE/GOOD MANUFACTURING PRACTICES

             

            1.

            Exposure to GMP in Bulk drugs and Formulations

            2.

            Excellent Computer literacy.

            3

            Prepared Drug master files and Site master files for submission to Foreign

            and  Local regulatory bodies.

            4.

            Conducted Process validations of Bulk drugs.

            5.

            Exposure to cleaning validations.

            6.

            Reviewing of SOP's for different departments.

            7.

            Reviewing of MFR's and BMR's

            8.

            All aspects of documentation with respect to GMP guidelines.

            9.

            Involved in a successful preparation for an audit  by the Australian

            regulatory  body." Therapeutic Goods Administration (TGA) "

            10.

            Similar involvement with a WHO audit of formulations

            11.

            Conducted several GMP audits.

            12

            Conducted several Vendor assessments.

             

            MANUFACTURING

            Practical  Production training in Pharmaceutical manufacturing in the following Departments.

            1. Powder injectibles

            2. Large Volume Parenterals (Haemaccel)

            3. Small Volume Parenterals (Liquid injectibles)

            4. Tablets.

             

            PROJECTS HANDLED AT RPG Life sciences ltd (formerly American multinational SEARLE INDIA  LIMITED,  1997-2003)

            (Drugs, Drug intermediates,Agrochemicals, intermediates for custom synthesis)

             

              

            1)

            Deltamethrin

            :

            Manufactured  3 tonnes on plant scale as R & D demonstration at an commercially viable cost, the process was developed from scratch ie  lit,lab work, scale-up, pilot trials and also included third party work. Later on annually about 25 tonnes were manufactured.

            2)

            Acetamiprid

            :

            Developed a process from scratch. Process was handed over to isagro  for commercialization in 2001 during hiving of the company from RPG

             

            3)

            M-alcohol an intermediate of  Tetra conazole

            :

            During isagro transition period in 2001, the process from Italy was adapted to Indian plant conditions, scaled up with some modification and handed over for commercialization. This is being produced on a regular basis.

            4)

            Pyrazosulfuron ethyl

            :

            Developed a process from scratch. Process was handed over to isagro  for commercialization in 2001 during hiving of the company from RPG

             

             

             

             

            pharmaceuticals

            1)

            Donepezil

            :

            Manufactured  4 kilos on  pilot plant scale as R & D demonstration, the process was developed from scratch. Plans are to make 25 kilos with 300% profit margins

             

            2)

            Pantoprazole

            :

            Process is being modified continuously to cope-up  with price crash

             

            3)

            PZL Chloride an intermediate of  Pantoprazole

            :

            Multi step process is being continuously modified / developed to meet cost demands

             

            4)

            Cilostazole

            :

            Under development

             

            5)

            Gatifloxacin

            :

            Developed a process which was not commercialized due to cheap drug available from china.

             

            6)

            Raloxifene

             

            Was involved in the scale up team supporting rapid commercialization of the drug

            7)

             Chiral Piperazine

             

             Developed this intermediate of Indinavir

            8)

            Int. of Glimepiride

             

            Developed 3 – ethyl – 4 methyl – 3- pyrrolin – 2 - one

                                                         

             

            Intermediates (custom synthesis)

             

            1)

            Thiol intermediate of raloxifene

            :

            Manufactured  2 kilos on  pilot plant scale as R& D demonstration( for CBZ . UK)

            2)

            TPCP

            :

            Manufactured 1 kilo in lab ( Aventis Germany)

            4-Phenyl-4-Piperidine carboxylic acid tosylate (TPCP)

            3)

            DBAP

            :

            Manufactured 0.250 kilo in lab( Aventis Germany)

            Ethyl-3-(N-(3,4 Dimethoxybenzyl)amino propionate

            4)

            MAPO

            :

            Methyl aziridine phoshonium oxide,100 kg in pilot plant (CBZ.  U.K.)

             

            5)

            6 HDHQ Int of cilostazole

            :

            Manufactured 0.250 kilo in lab ( Davos, USA)

             

             

            6)

            p-Trifluoromethyl benzonitrile

             

            Manufactured 1 kg for Rhodia,France

            7)

            6-MDHQ

             

            Manufactured 0.5 kg for Davos

             

             

            Experience at Innovassynth techologies limited

            a custom synthesis company catering to leading American and European multinationals (may2003_ dec05, 2 yrs 7 months)

            Headed a group  and worked on approx 25 custom synthesis projects with 18 scientists/chemists and 2 literature scientists.

             

            Dozen projects already executed and some in pipeline waiting for commercialization in the old and new pilot plants.

            ( clients include Bedoukain, CCR, polyfine, Novartis, lonza, Synergy, BASF, Austin,  FMC, Crompton, Semafore etc)

            projects commercialized

            1                    Guggulsterone

            2                    COENZYME Q10 Intermediate

            3                    N-(2,4 Dimethoxy phenyl) piperazine

            4                    2,6 -DMPI

            5                    Benzoic acid 4(4-propyl-1- piperazine)

            6                    2,4- dichloro 5- methoxyaniline

            7                    2- bromo hexanoic acid

            8                    CCTI

            9                    DMCPA.HCl

            10                Hexyl resorcinol

            11                Several in pipeline for commercialization

            12                60 samples sent for evaluation to foreign clients

             

             

            Experience at GLENMARK GENERICS LTD, Research Centre,(dec05-present)

             

            Currently working as principal scientist and leading a team of scientists in developing APIs for regulated markets, this involves novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis and commercialization and assist in providing support for DMF filing.

            Currently involved in development of SEVERAL targets for regulated markets. The job involves visualization of novel routes and its execution , simultaneously develop intellectual property and generate data in the process,. Provide support to US/European marketing team for developing and  execution of new projects

             

             

             

            WORKSHOP ATTENDED

            1.            Attended  workshop cum Course on SYNTHESIS OF ORGANIC CHEMICALS held on Feb. 1991 at University Department of Chemical Technology, Matunga – Bombay

             

            2.            Attended MANAGERIAL EXCELLENCE a 3 day workshop at HOECHST MARION ROUSSEL LTD. (Mulund,Mumbai), Bombay organized by Baroda Productivity Council, Baroda.

             

            PUBLICATIONS:

             

            1. A .M. Crasto and S. Seshadri

            Heterocyclic Analogues of Pyrethroids)Paper presented at the Thirteenth    International Congress of Heterocyclic Chemistry held at Corvallis, Oregon (U.S.A.) fromAug. 11th – 16th, 1991.  Abstract No. GE-11-129 (Paper presented by Prof.S. Seshadri.

             

                2.     A.M. Crasto  N. H.  Mehta and S. Seshadri

            Novel Pyrethroid Analogues Paper presented at Annual Conference 1989) of the Indian Council of Chemists held at Tirupati.  Abstract No. 00 – 35

             

                3.     A. M. Crasto and  S. Seshadri

            Synthesis of Novel & Chloromethyl esters via Regiospecific  ring opening reactions of aryl glycidyl ethers with acid chlorides and the synthesis of alpha-  morpholino methyl and  alpha-  cyano methyl esters. Paper presented at the 3rd Research Scholars Meeting, Indian Chemical Society, Feb. 1991.  Abstract No.

             

            4           SEVERAL PATENTS FILED

            PAGE CREATED BY DR ANTHONY MELVIN CRASTO M.SC, PH.D (ORGANIC CHEMISTRY,24+ years experience in the field of research and development

            NAME: DR. ANTHONY MELVIN CRASTO. 

            Principal scientist, GLENMARK-GENERICS LTD

            Navi mumbai, INDIA

            Email  amcrasto@gmail.com

             

            MOBILE+91-9323115463
            TWITTER-   @amcrasto





            web links
                    






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            Your Publications

            • Title:AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF

              Authors: A M CRASTO

              Ref. No: US 20100310870

              Year: 2010

              "The present invention relates to amorphous form of bazedoxifene acetate and a process for the preparation thereof."

            • A PROCESS FOR THE PREPARATION OF ATOVAQUONE CRYSTALLINE

              Authors: A M CRASTO ET AL

              Ref. No: 1742/MUM/2007 A

              Year: 2009

              "The present invention provides a process for the preparation of Atovaquone in a pure polymorphic form characterized by an X-ray powder diffraction pattern with peaks at about 7.0, 9.7, 14.2,..."

            • Process for the preparation of tadalafil

              Authors: A M CRASTO

              Ref. No: EP2004644 (A1)

              Year: 2008


            • Process for the preparation of atovaquone

              Authors: A M CRASTO

              Ref. No: US20090105350

              Year: 2008


            • Amorphous eprosartan mesylate and process for the preparation thereof

              Authors: A M CRASTO

              Ref. No: United States Patent Application 20080014263

              Year: 2007


            • PROCESS FOR THE PREPARATION OF TADALAFIL

              Authors: A.M. CRASTO

              Year: 2007


            • A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4-DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE

              Authors: A M CRASTO ET AL

              Ref. No: Application No.243/BOM/1999 A

              Year: 1999

              "A process for the preparation of methanamine-N-[4(3,4-dichlorophenyl)]-3,4-dihydro-1(2H)-naphthalenylidene, a critical intermediate in the synthesis of cis-(1S,4S)-4-(3,4-dichlorophenyl)-1,..."

            • Heterocyclic Analogues of Pyrethroids

              Authors: A .M. Crasto and S. Seshadri

              Thirteenth International Congress of Heterocyclic Chemistry , held at Corvallis, Oregon (U.S.A.) Abstract No. GE-11-129 ; 1991

              Thirteenth International Congress of Heterocyclic Chemistry , held at Corvallis, Oregon (U.S.A.) Abstract No. GE-11-129 ; 1991


            • SYNTHESIS OF NOVEL PYRETHROID ANALOGUES

              Authors: A.M. CRASTO

              MUMBAI UNIVERSITY, 1991

              Supervisor: PROF S . SESHADRI


            • Synthesis of Novel & Chloromethyl esters via Regiospecific ring opening reactions of aryl glycidyl ethers with acid chlorides and the synthesis of alpha- morpholino methyl and alpha- cyano methyl esters

              Authors: A. M. Crasto and S. Seshadri

              Paper presented at the 3rd Research Scholars Meeting, Indian Chemical Society, Feb. 1991. , TIRUPATI, INDIA; 1988

              Paper presented at the 3rd Research Scholars Meeting, Indian Chemical Society, Feb. 1991. , TIRUPATI, INDIA; 1988


              xxxx

              Anthony Melvin Crasto Ph.D

              Anthony Melvin Crasto Ph.D

              PRINCIPAL SCIENTIST, at Glenmark-Generics Ltd,Navi Mumbai,India, founder of Linkedin group Organic Process Development

              Thane, Maharashtra, India (Mumbai Area, India) 
              Pharmaceuticals

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              Anthony Melvin Crasto Ph.D's Overview

              Current
              Past
              • Principal scientist, GLENMARK PHARMACEUTICALS LTD research centreat Glenmark Pharmaceuticals
              • Sr Manager R&D or Group principal scientist at Innovassynth
              • Manager, research and development, API,RPG Life sciences ltd (formerly American multinational SEARLE at RPG Life Sciences

              see all

              Education
              • INSTITUTE OF CHEMICAL TECHNOLOGY (UDCT)
              • R.J.college, Ghatkopar, Bombay (Univ. of Bombay)
              • R .J.college, Ghatkopar, Bombay (Univ. of Bombay)

              see all

              Recommendations

              5 people have recommended Anthony Melvin

              Connections

              500+ connections

              Websites

              Anthony Melvin Crasto Ph.D's Summary

              Ph.D,Org Chem,ICT, Mumbai,India, amcrasto@gmail.com,9323115463, 25+ years in industry( API), mostly multinationals, process development in companies like Hoechst Marion Roussel(Sanofi aventis), Searle, RPG, Innovassynth, Glenmark, with exposure to basic research at SEARLE under Dr Nagarajan (Director Ciba), Tech transfer in plant eg deltamethrin 3 tonnes in RPG, bulk drug gmp (7 months) in Hoechst Marion Roussel(SANOFI AVENTIS), Custom syn in Innovasynth(SANDOZ, Basel, BASF Germany), exposure to natural pdts, drugs int, vet drugs, and some exposure in agro.speciality chemicals, flavours and fragrances, nutraceuticals and mettalocenes. ability to deliver products in the prodn plant(atleast 35 in career).
              highlights
              1. Felt proud to spend millenium night (2000) in plant
              2. Added personally a 25 kg sodium cyanide charge in a reactor at 2 in night, panoli, RPG.in 90'decade, not to be attempted again
              3. Did not run away and controlled an exotherm in plant batch due to accidental addn of acid.Cl into NaCN rxn 
              4. Sim. case when a thin film high vac distn exploded in a pilot plant in nasik for CBZ chem. UK, still able to despatch 100 kg material, Award london trip
              5. High vac. distilled 25 kg of drug int in the night using 3 pumps for a pilot plant trial intermediate, SANDOZ Basel, award bottle of wine from switzerland
              6. Personally worked after lab work in evenings with Dr Ralph Stapel , director. in modern, Hoechst pilot plant at Mulund Mumbai, in 80'
              7. Assisted Head Asia pacific, QA for TGA audit at Aventis plant ankleshwar
              8 Slept for 3 hrs in morning in first aid room in Panoli during Deltamethrin process demo at panoli Gujarat, then afternoon 2 hrs at guest house during 6 months campaign
              9 Reached Innovasynth lab in khopoli at 9 morning from mumbai,100 km, using trucks, ricks after july monsoon deluge in Mumbai 2005
              10 Got an opportunity to write a DMF in 90', hoechst, Got a chance to work in tablets,large vol parenterals, inj, vaccines in Hoechst mulund plant

              Specialties

              To carry out research and devpt, motivate, guide & lead a team of scientists,conduct lit.search,identify and execute new/novel routes for the synth,scale up from grams to kg levels in lab,conduct pilot trials/assist in prodn.upto ton levels. Carry out impurity profiles and assist in dossier writing. To keep in mind IPR issues and draft patents, file DMFS in US/EU, file patents and contribute to intellectual property,Ability to develop novel routes for API,s, well versed with polymorphism issues

              Anthony Melvin Crasto Ph.D's Experience

              Principal Scientist, Process research

              Glenmark Generics Ltd.

              Privately Held; 1001-5000 employees; glenmark; Pharmaceuticals industry

              December 2005 – Present (7 years 1 month) Mahape, Navimumbai, India, email me, amcrasto@gmail.com, 09323115463, call now

              Currently working with GLENMARK GENERICS LTD research centre as Principal Scientist, process research (bulk actives) at Mahape ,Navi Mumbai,and leading a team of scientists in developing APIs for regulated markets, this involves visualization and execution of novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis in lab and commercialization on plant , support for DMF filing.
              Currently, involved in development of several targets for regulated markets. Provide support to US/European marketing team for developing and execution of new projects
              Process Development :-
              • Providing guidance and support for process development for challenging of patents in regulated market.
              • Design patent non-infringing scalable synthetic routes/process and scale-up of API’s
              • Bench and Pilot scale synthesis transformations in hands on
              • Optimization of the process, ie,developing industrially feasible process.
              • Preparation of PDR, filing of patent and DMF
              • Lead a group of Scientists and Group Leaders(for docs). 
              Skill sets:- Technical skills:
              Synthesis:
              • Development of novel synthetic routes/process for pharmaceuticals and successful implementation of the technology in pilot plant
              • Conducted various reactions at laboratory and production scales. 
              • Synthesized various classes of compounds. 
              • Experienced to work under cGMP condition
              Documentation: 
              • Literature survey: well conversant with the use of Sci Finder and Internet search techniques.
              • Operating Instruction: Preparation of scale up report (process, yield, costing, quality, specification etc.).
              • Setting of specifications: Supported analytical section for method development and establishment of specification for Raw Material, Intermediate and finished products. 
              Soft skills:-
              • Creativity in problem solving, Highly motivated and Self-starting individual, Excellent communication skill,Team leader with good listening

              EX Hoechst Marion Roussel(SANOFI AVENTIS), RPG Life Sciences,Innovassynth, SEARLE,AGREVO,IOC

              Glenmark Generics Ltd.

              Privately Held; 1001-5000 employees; glenmark; Pharmaceuticals industry

              December 2005 – Present (7 years 1 month) email me, amcrasto@gmail.com, 09323115463, call now

              joined Glenmark with allround experience described in this profile, EMAIL, amcrasto@gmail.com, 09323115463 call now

              Principal scientist, GLENMARK PHARMACEUTICALS LTD research centre

              Glenmark Pharmaceuticals

              Public Company; 5001-10,000 employees; GLENMARK; Pharmaceuticals industry

              December 2005 – June 2007 (1 year 7 months) MAHAPE, INDIA, email me, amcrasto@gmail.com, 09323115463, call now

              RESEARCH ACTIVITIES COVERED IN THE ENTIRE CAREER
              1) Extensive range of chemistry and scale of manufacture from laboratory, scale up laboratory, pilot plant, plant scale including third party activity.

              Applied intellectual and synthetic skills to the process development of pharmaceutical drugs/their intermediates, and natural products, neutraceuticals, mettalocenes, speciality chemicals, flavours and fragrances in the laboratory and monitor them during plant trials.

              Act as a technology transfer man and provide all data required for transfer from lab to commercialization.

              Use of Internet and manual literature search methods to decide on non infringing route

              Write DHR for API before implementation of novel route in the plant and assist for all batches for the DMF purposes, very well versed with IPR issues 

              Ability to develop novel routes for API,s and draft patents,well versed with polymorphism issues.several patents filed in US/EU
              total exp23+ in industry, Currently working as principal scientist and leading a team of scientists in developing APIs for regulated markets, this involves novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis and commercialization and assist in providing support for DMF filing.
              Currently involved in development of several targets for regulated markets. The job involves visualization of novel routes and its execution , simultaneously develop intellectual property and generate data in the process,. Provide support to US/European marketing team for developing and execution of new projects

              Sr Manager R&D or Group principal scientist

              Innovassynth

              May 2003 – November 2005 (2 years 7 months) KHOPOLI, MH, INDIA, email me, amcrasto@gmail.com, 09323115463, call now

              led a team of 30 chemists for the custom synthesis business in the area of drugs, organic intermediates, speciality chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.customers were Sandoz Basel, BASF Germany, EMAIL, amcrasto@gmail.com, 09323115463 call now

              Manager, research and development, API,RPG Life sciences ltd (formerly American multinational SEARLE

              RPG Life Sciences

              Public Company; 1001-5000 employees; Pharmaceuticals industry

              October 1997 – May 2003 (5 years 8 months) PAWNE, MH, INDIA, email me, amcrasto@gmail.com, 09323115463, call now

              1 Donepezil : Manufactured 4 kilos on pilot plant scale as R & D demonstration, the process was developed from scratch. Plans are to make 25 kilos with 300% profit margins
              2) Pantoprazole : Process is being modified continuously to cope-up with price crash
              3) PZL Chloride an intermediate of Pantoprazole : Multi step process is being continuously modified / developed to meet cost demands
              4) Manufactured 3 tonnes deltamethrin on plant scale as R & D demonstration at an commercially viable cost, the process was developed from scratch ie lit,lab work, scale-up, pilot trials and also included third party work for one bromination step,which needed 8 reactors. Later on annually about 25 tonnes were manufactured. later on the company was taken over by a multinational for deltamethrin. the price in market crashed to half.
              5) Acetamiprid : Developed a process from scratch. Process was handed over to isagro for commercialization in 2001 during hiving of the company from RPG
              6) M-alcohol an intermediate of Tetra conazole : During isagro transition period in 2001, the process from Italy was adapted to Indian plant conditions, scaled up with some modification and handed over for commercialization. This is being produced on a regular basis.
              7) Pyrazosulfuron ethyl : Developed a process from scratch. Process was handed over to isagro for commercialization in 2001 during hiving of the company from RPG
              MANY PROJECTS ON CUSTOM SYNTHESIS FOR CBZ, PFIZER, AVENTIS, ETC WERE DONE DURING THIS TENURE IN RPG LIFE SCIENCES

              Manager, R &D-sister concern of RPG--1 MONTH, ISAGRO INDIA PVT LTD-- AN ITALIAN MULTINATIONAL

              Isagro S.p.A.

              Privately Held; 501-1000 employees; Chemicals industry

              January 2003 – February 2003 (2 months)

              Carried out Synthetic Research work partly at (R&D) at RPG RESEARCH CENTRE NAVIMUMBAI- PLANT WAS AT PANOLI,email me, amcrasto@gmail.com, 09323115463, call now

              7 MONTHS ONLY WITH GMP/QA DEPT AND REPORTING TO GMP HEAD , ASIA PACIFIC

              HOECHST MARION ROUSSEL

              Public Company; 10,001+ employees; SNY; Pharmaceuticals industry

              April 1997 – October 1997 (7 months) MULUND, INDIA, email me, amcrasto@gmail.com, 09323115463, call now

              QUALITY ASSURANCE/GOOD MANUFACTURING PRACTICES

              1. Exposure to GMP in Bulk drugs and Formulations

              2. Excellent Computer literacy.

              3 Prepared Drug master files and Site master files for submission to Foreign
              and Local regulatory bodies.

              4. Conducted Process validations of Bulk drugs.

              5. Exposure to cleaning validations.

              6. Reviewing of SOP's for different departments.

              7. Reviewing of MFR's and BMR's

              8. All aspects of documentation with respect to GMP guidelines.

              9. Involved in a successful preparation for an audit by the Australian
              regulatory body." Therapeutic Goods Administration (TGA) "

              10. Similar involvement with a WHO audit of formulations

              11. Conducted several GMP audits.

              12 Conducted several Vendor assessments.


              MANUFACTURING
              Practical Production training in Pharmaceutical manufacturing in the following Departments.
              1. Powder injectibles

              2. Large Volume Parenterals (Haemaccel)

              3. Small Volume Parenterals (Liquid injectibles)

              4. Tablets.

              Executive BULK DRUG QA for short time at German multinational Hoechst Marion Roussel Ltd [

              HOECHST INDIA LIMITED

              April 1997 – October 1997 (7 months)

              VISITED TABLETS, LARGE VOLUME PARENTERALS, INJ, STORES ETC AS PART OF GMP TRAINING

              CUSTOM SYNTHESIS

              BASF

              Public Company; 10,001+ employees; BAS.DE; Chemicals industry

              March 1997 – May 1997 (3 months)

              CUSTOM SYNTHESIS OF API, Eg COENZYME Q10, ETC

              PROJECTS HANDLED IN CUSTOM SYN AREA

              Sandoz

              Public Company; 10,001+ employees; NVS; Pharmaceuticals industry

              March 1997 – May 1997 (3 months)

              MANY PROJECTS ON CUSTOM SYNTHESIS FOR CBZ, PFIZER, AVENTIS, ETC WERE DONE DURING THIS TENURE IN INNOVASSYNTH

              Executive process development for short timeHOECHST SCHERING AGREVO a sister concern of HMR,

              HOECHST SCHERING AGREVO

              February 1997 – May 1997 (4 months)

              PROCESS DEVELOPMENT OF AGROCHEMICALS FOR VERY SHORT TIME SINCE THIS COMPANY WAS A SISTER CONCERN OF HOECHST MARION ROUSSEL AND REPORTED TO DR RALPH STAPEL,DIRECTOR PROCESS DEVELOPMENT(ANILOPHOS, DELTAMETHRIN, TEFURAMETHRIN)

              Exec proc.development pharmaceuticals, Hoechst Marion Roussel, now Sanofi Aventis

              sanofi-aventis

              Public Company; 10,001+ employees; SNY; Pharmaceuticals industry

              January 1993 – January 1997 (4 years 1 month)

              MULUND, Mumbai. INDIA The job involved all aspects of synthesis and commercialization from research lab to production,
              PROJECTS HANDLED:
              1.Pentoxyfylline : Independently developed a new route

              2.Roxatidine : In a team worked on some of its intermediates; Process development and production trouble Shooting

              4.ECPPA : Independently developed a 5 step route for the 
              synthesis of this single isomer (Enalapril/Ramipri
              Intermediate)

              5.Furamethrin Alc : Independently developed a commercially viable route for its manufacture involving Acetylene as the raw material. 

              6.Tefuramethrin : Independently developed its synthesis for M/S
              Diannihon Jochugiko Japan.

              7. Several Drugs/ Vet.Drugs : Trouble shooting for production (eg. PitofenoneHCl, Frusemide, Ramipril, etc.)

              PROJECTS HANDLED as Management Trainee Research and devl. SEARLE INDIA LTD

              Searle

              Public Company; 10,001+ employees; Pharmaceuticals industry

              May 1991 – December 1992 (1 year 8 months) PAWNE, INDIA

              1 year 7 months)
              (Drugs and Natural products )

              1) Azathioprine :worked on all the steps. ALSO WORKED ON CANNABINOID DRUGS, OLIVETOL, worked on menthadienol, iohexol, x ray contrast agents, EMAIL, amcrasto@gmail.com, 09323115463 call now

              ORGANIC process development, INDIAN ORGANIC CHEMICALS, KHOPOLI, INDIA

              INDIAN ORGANIC CHEMICALS

              January 1987 – April 1991 (4 years 4 months)

              DID ORGANIC PROCESS DEVELOPMENT AS A RESEARCH FELLOW, email me, amcrasto@gmail.com, 09323115463, call now

              Ph. D research fellow, Organic chemistry

              Institute Of Chemical Technology

              Educational Institution; 501-1000 employees; Education Management industry

              January 1987 – April 1991 (4 years 4 months) MATUNGA, MUMBAI, INDIA,email me, amcrasto@gmail.com,09323115463

              4years
              Worked as Indian Organic; PhD programme(organic chemistry) on the topic " Synthesis of novel pyrethroids analogues". Simultaneously did project work for IOC.

              Anthony Melvin Crasto Ph.D's Publications

              • Heterocyclic Analogues of Pyrethroids

                • ACS

                A .M. Crasto, S. Seshadri
                Thirteenth International Congress of Heterocyclic Chemistry, held at Corvallis, Oregon (U.S.A.) Abstract No. GE-11-129; 01/1991

              • Synthesis of Novel & Chloromethyl esters via Regiospecific ring opening reactions of aryl glycidyl ethers with acid chlorides and the synthesis of alpha- morpholino methyl and alpha- cyano methyl esters

                • ICS

                A. M. Crasto, S. Seshadri
                Paper presented at the 3rd Research Scholars Meeting, Indian Chemical Society, Feb. 1991., TIRUPATI, INDIA; 01/1988

              Anthony Melvin Crasto Ph.D's Volunteer Experience & Causes

                • WEBSITE OWNER

                  MILLION HITS ON GOOGLE
                  • Education
                  January 2011 – present (2 years)

                  MILLION HITS ON GOOGLE ON ALL CHEMISTRY SITES, HELPING MILLIONS, ACCLAMATION WORLDWIDE

                • One lakh plus connections worldwide on all sites and counting,

                  One lakh plus connections worldwide on all sites and counting,

                    One lakh plus connections worldwide on all sites and counting, NETWORKING SITES TRACKER 
                    on linkedin, researchgate, academia.edu, dikajob, scipeople, gplus, facebook, buzz, diigo, mashable, siliconindia, epernicus, aboutme, skillpages, viadeo, apnacircle, skilledpeople, wordpress, google gps, wix, jimdo, yolasite, bravenet, mendeley, orkut,

                  • CHEM BLOG

                    WIX BLOG
                    • BLOG

                      EUREKA MOMENTS
                      • Causes I care about:

                        • Animal Welfare
                        • Children
                        • Disaster and Humanitarian Relief
                        • Education
                        • Environment
                        • Health
                        • Human Rights
                        • Poverty Alleviation
                        • Science and Technology
                        • Social Services
                      • Organizations I support:

                        • MILLION HITS ON GOOGLE, on all chemistry websites, helping millions,
                        • u r will power and determination will see u out of storm even if u r in drowning in middle of the oc

                    Anthony Melvin Crasto Ph.D's Languages

                    • English

                       (Full professional proficiency)
                    • HINDI

                       (Native or bilingual proficiency)
                    • MARATHI

                       (Native or bilingual proficiency)
                    • TULU

                       (Native or bilingual proficiency)
                    • GERMAN

                       (Elementary proficiency)

                    Anthony Melvin Crasto Ph.D's Projects

                    Anthony Melvin Crasto Ph.D's Organizations

                    • million hits on google

                      helping millions

                        u r will power and determination will see u out of storm even if u r in drowning in middle of the ocean amcrasto@gmail.com, 9323115463 email me, call now
                        " I have closely brushed with death and pulled back, go out and enjoy, life is so precious ask me"
                        If saturday, sunday don't excite u then change u r friends........., if monday doesn't motivate u then change u r profession............!!! 
                        ...more

                      Anthony Melvin Crasto Ph.D's Honors and Awards

                      • MILLION HITS ON GOOGLE

                        GOOGLE
                        • January 2010

                        Million hits on all websites, world acclamation for the same, helping millions, email me, amcrasto@gmail.com, 09323115463, call now

                      • chemistry sites

                        Algerian universities
                        • January 2011

                        appreciation of organic chemistry websites and blogs

                      • chemistry blogs

                        middleeast agencies
                        • January 2012

                        acclamation of efforts, particularly translators on blogs

                      • several mails

                        russian, chinese, scandinavian, brazil, universities and agencies
                        • February 2012

                        appreciation of efforts on net

                      • Pakistan universities

                        Appreciation for organic chemistry sites
                        • March 2012

                        Appreciation for organic chemistry sites

                      • King Fahd university

                        Appreciation for organic chemistry sites
                        • April 2012

                        Appreciation for organic chemistry sites

                      • Education excellence

                        UAE education agency
                        • February 2011

                        EFFORTS TO BRING OUT EDUCATION

                      • CHINA UNIV, AND DRUG AGENCIES

                        DRUG SITES
                        • January 2011

                        TRANSLATION METHODS

                      • CANADA AYURVEDA

                        CANADA AYURVEDA
                        • March 2010

                        CANADA AYURVEDA FOR PROMOTING IT ON WEBSITES

                      • NEPAL UNIV , ADADEMIA AND GRUG AGENCIES

                        CONTRIBUTION OF WEBSITES
                        • May 2011

                        CONTRIBUTION OF WEBSITES

                      • Bangladesh academia, industry, drug agencies

                        all round inf source
                        • March 2011

                        all round inf source on drugs

                      • NIGERIA, GHANA, SUDAN, EHIOPIA, KENYA UNIV

                        DRUG SITES
                        • December 2010

                        NIGERIA, GHANA, SUDAN, EHIOPIA, KENYA UNIV, DRUG SITES

                      • Chile , mexico, bolivia, argentina drug agencies

                        Chile , mexico, bolivia, argentina drug agencies
                        • January 2011

                        Chile , mexico, bolivia, argentina drug agencies, email me, amcrasto@gmail.com, 09323115463, call now

                      • ONE LAKH CONNECTIONS PLUS ON ALL NETWORKING SITES AND STILL COUNTING

                        NETWORKING SITES TRACKER

                          ONE LAKH CONNECTIONS PLUS ON ALL NETWORKING SITES ,NETWORKING SITES TRACKER
                          on linkedin, researchgate, academia.edu, dikajob, scipeople, gplus, facebook, buzz, diigo, mashable, siliconindia, epernicus, aboutme, skillpages, viadeo, apnacircle, skilledpeople, wordpress, google gps, wix, jimdo, yolasite, bravenet, mendeley, orkut,

                        Anthony Melvin Crasto Ph.D's Certifications

                        • DIPLOMA IN INDUSTRIAL AND ANALYTICAL CHEMISTRY

                          • CIPLA RUIA TDM LAB
                        • GENERAL ELECTRONICS

                          • BOMBAY INSTITUTE OF TECHNOLOGY
                        • DIPLOMA IN BUSINESS MANAGEMENT

                          • WELINGKAR INSTITUTE, PODAR COLLEGE, MUMBAI
                        • COMPUTER PROGRAMMING, MULUND, MUMBAI

                          • EMAIL me, amcrasto@gmail.com, 09323115463 call now
                        • MILLION HITS ON GOOGLE, HELPING MILLIONS

                          • WORLD ACCLAMATION,email me, amcrasto@gmail.com, 09323115463, call now
                        • ONE LAKH CONNECTIONS PLUS WORLDWIDE ON ALL NETWORKING SITES

                          • NETWORKING SITES TRACKER

                        Anthony Melvin Crasto Ph.D's Patents

                        • Process for the preparation of atovaquone

                          • United States Patent US20090105350
                          •  
                          • Issued October 9, 2008

                          Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
                          API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN

                        • Process for the preparation of tadalafil

                          • Europe Patent WO 2007110734

                          Process for the preparation of tadalafil, ep also EP2004644
                          Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
                          API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN
                          Process for the preparation of tadalafil
                          PCT Application WO2007110734 
                          Filed: 03/23/2007 
                          Published: 10/...more

                        • Amorphous eprosartan mesylate and process for the preparation thereof

                          • United States Patent US20080014263

                          Amorphous eprosartan mesylate and process for the preparation thereof
                          Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
                          API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN

                        • Method for preparation of dronedarone via palladium-catalyzed hydrogenation and methanesulfonylation

                          • Europe Patent WO 2012007959
                          •  
                          • Issued January 2012

                          Method for preparation of dronedarone via palladium-catalyzed hydrogenation and methanesulfonylation WO 2012007959
                          Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
                          API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN

                        • Method for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates

                          • Europe Patent WO 2011158250
                          •  
                          • Issued December 22, 2011

                          Method for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates ETORICOXIB
                          Several international drug patents throughout the career, type Anthony melvin crasto patents in google for full range,email me, amcrasto@gmail.com, 09323115463, call now
                          API PATENTS, NIP ROUTE,POLYMORPH OR PROCESS IN US,EU,INDIAN

                        • Amorphous eprosartan mesylate and process for the preparation thereof

                          • United States Patent US 20080014263
                          •  
                          • Issued January 17, 2008

                          Amorphous eprosartan mesylate and process for the preparation thereof

                        • AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF

                          • United States Patent US 20100310870

                          US 20100310870, AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF

                        • A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4-DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE

                          • India Patent INDIAN PAT Ref. No: Appl No.243/BOM/1999 A, Year: 01/1999
                          •  
                          • Issued January 1, 1999

                          A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4-DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE
                          Ref. No: Application No.243/BOM/1999 A, Year: 01/1999

                        • IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL

                          • India Patent INDIN PAT Ref. No: 1135/MUM/2006
                          •  
                          • Issued July 18, 2008

                          Ref. No: 1135/MUM/2006 - Published: 2008-07-18 - GLENMARK PHARMACEUTICALS LIMITED, Year: 07/2008

                        • A PROCESS FOR THE PREPARATION OF ATOVAQUONE CRYSTALLINE

                          • India Patent Ref. No: 1742/MUM/2007 A, Year: 01/2009
                          •  
                          • Issued January 1, 2009

                          Ref. No: 1742/MUM/2007 A, Year: 01/2009

                        Anthony Melvin Crasto Ph.D's Education

                        INSTITUTE OF CHEMICAL TECHNOLOGY (UDCT)

                        Ph.D.ORGANIC CHEM.

                        1987 – 1991

                        THESIS synthesis of novel pyrethroid analogues, email me, amcrasto@gmail.com, 09323115463, call now

                        Activities and Societies: Ph.D Programme,ICT, Formerly University Department of Chemical Technology, Matunga, Mumbai, India, email me, amcrasto@gmail.com, 09323115463, call now

                        R.J.college, Ghatkopar, Bombay (Univ. of Bombay)

                        M.Sc.Organic Chemistry

                        1986

                        R .J.college, Ghatkopar, Bombay (Univ. of Bombay)

                        B.ScChemistry

                        1984

                        R.J. COLLEGE GHATKOPAR MUMBAI

                        HSCSCAIENCE

                        1979 – 1981

                        St. Xavier`s high School, POWAI, MUMBAI

                        S.S.CGENERAL

                        1970 – 1979

                        email me, amcrasto@gmail.com, 09323115463, call now

                        Anthony Melvin Crasto Ph.D's Additional Information

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                        million hits on google on all sites


                       

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