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PAGE CREATED BY DR ANTHONY MELVIN CRASTO M.SC, PH.D (ORGANIC CHEMISTRY,29+ years experience in the field of research and development
email  amcrasto@gmail.com





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8 Jun 2009 ... PILOT PLANT SCALEUP TECHNIQUE. Dr. Basavaraj K. Nanjwade M. Pharm., Ph. D. Associate Professor. Department of Pharmaceutics ...
api.ning.com/files/.../PilotScaleUpTechnique.ppt - Similar

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Pilot Plant through Scale-Up Manufacturing

 
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Pilot Plant through Scale-Up Manufacturing. Martha A. Feldman, RAC .... Records; Servicing; Statistical Techniques. Feldman 20 February 2003 ...
www.lifesciencesbc.ca/.../M_Feldman_Pilot_plant_to_manufacturing.ppt - Similar
What are the most important things to keep in mind when scaling up a new batch chemical process?

Some of the most valuable advice about process scaleup consists of information not found in engineering course curricula or textbooks, but rather comes from experiences learned on the job. Unfortunately, this situation can result in some costly, time-consuming and potentially hazardous lessons.

Several years ago, I compiled the following list of things I considered important to a safe and successful scale-up in the kilo-lab or pilot plant. I call it my list of "12 things to do and to avoid" in process scale-up. Many are just common sense, and many are expected practice in the fine-chemical and pharmaceutical industries, but all of them can help save time, avoid mistakes, streamline the development cycle, and allow you to reap the maximum 

benefit from the scale-up experience.

12 things to do

1. Operating philosophy

Develop an overall pilot-plant operating philosophy and guidelines for the minimum documentation required before a new process can be run in plant equipment - for example, a detailed laboratory process description, process safety information package, etc. Get management buy-in and support, so that you can enforce these requirements.

2. Equipment logbooksSet up operating and maintenance log books for each major piece of equipment in the plant (e.g., reactors, filters, dryers, pumps, hoses, etc.). In them, document all batches, cleaning operations, test results, and any maintenance performed, beginning with the date of installation and qualification. Laboratory notebooks work well for this.

3. Sample databaseSet up a sample log book or database. Using any reasonable numbering system, list in it every single sample collected in the plant for testing or retention. Include batch number, step number, time collected, purpose, test results, etc. This will become an invaluable archive for future reference, and will help ensure that important data are not lost. There may never be another opportunity to generate many of the samples collected during scale-up batches.

4. Retain samplesKeep samples of all isolated products or intermediates produced in the kilo-lab or pilot plant. Store them in a cool, dark, dry place, or as appropriate for the particular material.5. Collaboration

Encourage engineers and chemists to communicate early in process development and route selection. The most successful processes result from a collaboration between those who best understand the chemistry and those who best understand the physical and mechanical limitations of the pilot equipment and the operations that may or may not be considered acceptable.

6. Fix the process

Try to solve any problems and finalize the process well in advance of scale-up so that there is time to focus on ensuring that the batch can be scaled up safely. Making changes on the fly or "experimenting" at scale can create unforeseen hazards.

7. HAZOP

Perform a hazard and operability review (HAZOP) each time you bring a new process into the plant. This should be conducted by a team of in-house experts from various departments and should include a process walk-through and a detailed review of process safety information, contingency plans and emergency preparedness.

8. Energetics

Insist on calorimetric testing to determine the stability of components, heats of reaction, potential for decomposition and potential magnitude of thermal runaways. Most adverse events in chemical processing occur because of poorly understood chemical reactivity or insufficient heat removal.

9. Batch record

Create a written batch record (batch log sheet) for each batch you conduct, even at kilo-scale. Master records should be reviewed and signed by representatives of the departments involved (R&D, Engineering, etc.). Document change control is particularly important to track revisions and ensure that the most recent version is in use.

10. Raw material grade

Conduct development experiments using technical-grade raw materials, or materials obtained directly from proposed large-scale suppliers. They will be more representative of future manufacturing sources.

11. Raw-material use test

Always perform a lab-scale use test using the actual lots of all raw materials and in-house intermediates earmarked for the pilot batch. Ensure that the product made meets specifications before proceeding with the scale-up. If a pilot batch later gives unexpected results, you'll be able to eliminate raw materials as a source of the problem.

12. Seize the opportunity

Make the maximum use of each batch. Take as many in-process samples as practical and retain them for later troubleshooting. This includes key effluent streams. Use the opportunity to collect mass balance data, to test your energy balance relationships, and to verify analytical methods. Document all significant details in a campaign or batch report to make the information readily accessible at a later date

.

12 things to avoid

1. Keep it simple

Avoid reactions that require highly specialized equipment, or that are known to be hazardous and require special safety facilities, such as nitration reactions. At a minimum, obtain full calorimetric data and compare them to the maximum heat removal rate of the reactor. If necessary, consider outsourcing (tolling) such reactions to companies that specialize in them.

2. Heating

Never heat a reactor without agitation. It can create hot spots that can erupt into violent boiling when the mixer is turned on or initiate unexpected decomposition. Never stop the agitator until a reaction mixture has cooled to a safe temperature.

3. Decomposition

Do not operate a reactor at a temperature within 50°C of the known onset temperature of an exothermic decomposition reaction that might run out of control.

4. Solids addition

Avoid having to add solid reagents to a reacting mixture. Manual addition can be extremely dangerous, and while screws, conveyors and other apparatus for contained largescale solids addition are available, they are often unreliable and expensive. Similarly, do not add solids to a hot or refluxing mixture.

5. Evaporation

Do not develop a process that relies on the common laboratory technique of evaporating to dryness or to very low volumes. Most large-scale reactors have a minimum stir volume of about 20% of their capacity.

6. Exotherms

Try to avoid "all in and heat" operation (adding all reagents to the vessel and then heating up). Because of diminished heat-removal capacity at large scale, exothermic reactions can cause a thermal runaway. Exothermic decomposition reactions may follow, putting the reaction beyond any chance of operator control. Rapid gas evolution can compound the problem. It is better to design reactions so they can be controlled by slow addition of a limiting reagent at a rate that matches the equipment's cooling capacity. As a corollary to this rule, never add a catalyst to a reaction mixture last.

7. Timing

Avoid reactions that must be worked up or isolated "immediately," such as the kinetic resolution of some enantiomers. At commercial scale, many operations can take orders of magnitude longer than in the lab. Solid product isolation alone can take 24 hours or longer. For this reason, try to ensure that the product slurry or the stream of interest is stable for a sufficient length of time.

8. Solvents

Avoid using solvents that are considered environmental hazards or that may not be permitted in human pharmaceuticals, etc., such as méthylène chloride or other halogenated compounds. Beyond permitting difficulties, waste treatment or removal costs at manufacturing scale can often make a process uneconomical.

9. Filtration

Avoid hot filtrations or polish filtrations of highly saturated solutions. Solids can crash out quickly in pipes or lines and clog the filter or other equipment. To prevent this in the plant, lines often have to be steam-traced or preheated.

10. Extractions

Try to avoid reverse phase splits (where the upper phase goes to waste). Such operations require the addition of another vessel to the equipment train, a considerable expense at the manufacturing scale, and add time to the process cycle. Likewise, when quenching reactions with water, remember that at large scale, it is most common to add the quench to the batch and not the other way around.

11. Chromatography

Try to avoid using flash chromatography for purification. While useful in the lab, it is used commercially only for very-high-value products or where there is no other choice. Even then, chromatography requires very large amounts of solvents and support material. It is better to develop a salt or other crystalline form.

12. Play it safe

Don't risk all of your limited raw materials or intermediates on one batch! Be prepared for the possibility that the batch, especially in a new process, may still hold surprises in spite of your careful preparations. Operator errors or errors in the batch record are also more likely the first time through a new process.



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Points to be kept in mind during scaleup
process Design for Scale-Up
   •  Process development strategies
   •  Importance of engineering in PD
Scale-Up – An Overview
   •  Role of the Pilot Plant
   •  Overview of scale-up issues
   •  Technology transfer issues
Batch Reactors
   •  Typical plant operations and equipment
   •  Characteristics of batch operations
Raw Materials
   •  Raw material and route selection
   •  Large-scale charging methods and issues
Temperature Control
   •  Large scale temperature control
   •  Heat transfer in batch reactors
   •  Controlling exothermic reactions
Following Reaction Progress
   •  Reaction endpoint determination
   •  Sampling methods / issues
   •  On-line analytical techniques
Agitation and Mixing
   •  Large scale mixing equipment
   •  Mixing limited reaction
   •  Mixing scale-up / scale-down
Quench & Work-Up
   •  Liquid-liquid extractions
   •  Phase continuity issues and emulsions
Distillation & Stripping
   •  Differential distillation
   •  Azeotropes and solvent exchange
Crystallization and Precipitation
   •  Basic principles / yield estimation
   •  Controlling supersaturation
   •  Scale-up issues
Product Isolation and Drying
   •  Large-scale solid-liquid separations
   •  Filtration and drying equipment
   •  Filtration and drying modeling
Process Hazards and Safety Assessment
   •  Common hazards in large-scale processing
   •  Process hazard assessments and 
evaluation

Objectives
 To inbibe  practical aspects of designing a scaleable fine-chemical batch process and successfully implementing it at the  kilo-lab and pilot plant scale, through an examinationof the effects of large-scale operating methods and equipment limitations 
on process safety, operability, yield, selectivity and product quality. 

• Assess process safety and scaleability
• Identify process operations that may be 
problematic on scale-up
• Design processes that will minimize or 
avoid scale-up issues
• Select operating methods and 
equipment for effective scale-up
• Calculate heat removal rates and safe 
rates of addition of reagents
• Determine mixing requirements for 
scale-up
• Design crystallizations which can be 
successfully operated at scale
• Predict the filterability of solid products 
upon scale-up
• Minimize the effects of scale-up on 
yield, selectivity and product purity


 
NAME: DR. ANTHONY MELVIN CRASTO. 

Principal scientist, GLENMARK-GENERICS LTD

Navi mumbai, INDIA

Email  amcrasto@gmail.com

 

MOBILE+91-9323115463
TWITTER-   @amcrasto


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Pilot Plant through Scale-Up Manufacturing

 
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Pilot Plant through Scale-Up Manufacturing. Martha A. Feldman, RAC .... Records; Servicing; Statistical Techniques. Feldman 20 February 2003 ...
www.lifesciencesbc.ca/.../M_Feldman_Pilot_plant_to_manufacturing.ppt - Similar

 Distillation Pilot Plant Design, Operating Parameters and ...
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Distillation Pilot Plant Design, Operating Parameters and Scale-up ... Distillation Pilot Plant Design, Operating Parameters, and Scale-Up Considerations ...
Source: www.umss.edu.bo

 SCALE-UP OF A PILOT PLANT FOR ADSORPTION OF HEAVY METALS
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Scale-Up of a Pilot Plant for Adsorption of Heavy Metals. Results and discussion. As the carbon is saturated, the adsorption zone moves towards the bottom of the bed; this. zone is known as the mass transfer zone (MTZ) and corresponds to the region where the initial ...
Source: www.aqa.org.ar

 Pilot Scale-up and Process Control in Product Development
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scale-up to meet the capacity of the pilot plant. equipment and regulatory requirements. ... 2. Pilot plant scale-up Techniques by Samuel Harder, Glenn vann Buskrik published in the ...
Source: www.ipapharma.org

 Bench Scale & Pilot Plant Testwork For Gravty Concentratioƒ
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appropriate unit operations, bench- and pilot- scale testing and their limitations, and scale-up for ... environmentally sensitive, techniques to produce the final desired product. ...
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 The Acetone-Butanol Fermentation in Pilot Plant and Pre ...
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described or mentioned- the scale-up step. This may be. because ... in pilot plant scale have shown that the problems of. degeneration, contamination or phage ...
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 CFD MODELLING IN THE SCALE-UP OF A STIRRED REACTOR FOR THE ...
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vectors in the pilot-plant reactor indicate that there are two ... produced in the pilot-plant and full-scale reactors are. affected by the maximum ...
Source: www.cfd.com.au



 COMPANY TO BUILD INDUSTRIAL-SCALE PILOT PLANT TO PRODUCE ...
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Planning for construction of the industrial-scale pilot plant is ... associated with scale-up, and will enable the "right-sizing" of costly. equipment. This will simultaneously ...
Source: www.infomine.com

 Fractional Crystallization Pilot Plant Test Program Objectives
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unit operations shown on the Pilot Plant Crystallization System. Process Flow Diagram (PFD) ... Use the same analytical technique at different labs. • Train analytical staff to the same techniques used for lab. scale testing. Fractional Crystallization Pilot Plant. Areas of Discussion. • Phase III Testing ...
Source: www.em.doe.gov

 Fractional Crystallization Pilot Plant Test Program Objectives
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unit operations shown on the Pilot Plant Crystallization System. Process Flow Diagram (PFD) ... Use the same analytical technique at different labs. • Train analytical staff to the same techniques used for lab. scale testing. Fractional Crystallization Pilot Plant. Areas of Discussion. • Phase III Testing ...
Source: www.em.doe.gov

 Evaluation of Ozone Treatment, Pilot-Scale Wastewater ...
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Evaluation of Ozone Treatment, Pilot-Scale Wastewater Treatment Plant, and ... will include many elements and techniques commonly used in domestic, and sometimes. in industrial wastewater treatment. ...
Source: scholar.lib.vt.edu



SCALEUP OF ORGANIC PROCESSES

site for SCALEUP used in organic synthesis, part of main page shown below





PAGE CREATED BY DR ANTHONY MELVIN CRASTO M.SC, PH.D (ORGANIC
 CHEMISTRY,
24+ years experience in the field of research and development
email  amcrasto@gmail.com

Ентоні  アンソニー  Αντώνιος  安东尼    แอนโทนี   Энтони   אַנטאַני  
Антхони  एंथनी  안토니  أنتوني




 SAFETY ISSUES IN THE SCALE UP OF CHEMICAL REACTIONS
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up of chemical processes and should contribute to the scale up procedure in order to ... cases several pilot plants of. increasing size may be used to effect the best design for the larger plant. Risk. assessment is an evolving process as scale-up progresses. ...
Source: www.rsc.org



 Scale-up and Demonstration of Fischer-Tropsch Technology
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Technology and scale-up issues. The advantages described in Ch. 2.1. were all identified and formed the basis for ... through an intermediate size pilot plant and rather build a demonstration plant of semi ...
Source: www.nt.ntnu.no

 CrySTAllIzATIOn TEChnOlOgy
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scale, pilot plant or commercial-scale level including: • Design ... pilot plant and plant data. • Perform basic troubleshooting. • Define scale-up techniques ...
Source: www.sitec-pharmabio.com

 ON ON - - SITE MICROWAVE SITE MICROWAVE - - ASSISTED PILOT ...
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This pilot plant will be engineered by Bi.Elle s.r.l.. Preliminary ... As for the prototype, a scheme of the pilot scale plant for filtering asbestos ...
Source: venus.unive.it

 The Pilot Plant Real Book
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and contains countless tips and techniques for the safe and ef- fective scale-up of new chemical processes. ... The role of the pilot plant in chemical development, guidelines for developing scaleable reactions, process. safety screening, Haz-Ops, cGMP, tips for maximizing ...
Source: www.pprbook.com

 PDF
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In some cases several pilot plants of increasing size may be used to ... the larger plant. During the scale up process it is useful to develop a "basis for safe operation" that ...
Source: www.rsc.org

 A pilot-plant study of the adsorptive micellar flocculation ...
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A pilot-plant scale study of the adsorptive micellar flocculation (AMF) process is presented for the ï¬ rst time, and builds on the solid foundation ... ment technique, pilot studies are essential. Their aims, which. are reported here for the ï¬ rst time, are to establish guidelines. for optimum design ...
Source: homepage.ntlworld.com

 DETERMINATION OF METHYL MERCURY IN A PILOT-SCALE ACTIVATED ...
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The analytical technique utilized during the present work (GC-MS) is one of the most ... satisfactory results. Moreover, the high temperature during the pilot-plant experiment as well. as the high concentration of ...
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 CHAPTER 4 PILOT PLANT TESTS AND EVALUATIONS 4.1 INTRODUCTION
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The plant. configurations consist of a DMC circuit and cyclone overflow circuit in the pilot plant. operations. ... Set-Up. All of the pilot-scale continuous units (i.e., Peterson disc filter, VT HBF, Westec drum. filter, Sepor ...
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 Oftec Pilot Plant and Laboratory facilities
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analyses, and pilot plant facilities to support the role of the division as a ... PILOt PLANt. The margarine pilot plant facilities (Figure 1) were set up to service ...
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 Roll Compaction Granulation of a Controlled-Release Matrix ...
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equipment scale-up on tablet robustness of a model. matrix controlled-release formulation that contained ... direct pilot-plant scale-up, Trial 2. Therefore, there does not ap ...
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 PILOT PLANTS
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pilot plant construction, development, scale-up, engineering design, ... answer to the scale-up question, must. also come from the pilot plant. ...
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 Poly-beta-hydroxybutyrate Pilot Plant
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Taking a new chemistry from lab scale to pilot plant scale was the objective of this ... Another area for future work would be to scale up our process to a full scale plant ...
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 Modeling Tomorrow's Biorefinery - the NREL Biochemical Pilot ...
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Pilot Plant housed in the Alternative Fuels. User Facility (AFUF). In this facility, ... at the bench scale or they can test entire. conversion processes at the "mini-pilot. plant" scale (10- to 100-L vessel size) or at ...
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 The Scale-Up of Chemical Processes
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Pilot Plant. Production. Manufacturing. We've Got Chemistry. The 11th International Conference and Exhibition. www.scientificupdate.co.uk. The Scale-Up of ... and techniques with the key people in the industry. Book your place today at the premier Scale Up conference. ...
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CONTINUED

encourage engineers and chemists to communicate early in process development and route selection. 

The most successful processes result from a collaboration between those who best understand the chemistry and 

those who best understand the physical and mechanical limitations of the pilot equipment and the operations that may

 or may not be considered acceptable.

6. Fix the process

Try to solve any problems and finalize the process well in advance of scale-up so that there is time to focus on ensuring 

that the batch can be scaled up safely. Making changes on the fly or "experimenting" at scale can create unforeseen hazards.

7. HAZOP

Perform a hazard and operability review (HAZOP) each time you bring a new process into the plant. This should be 

conducted by a team of in-house experts from various departments and should include a process walk-through and a

 detailed review of process safety information, contingency plans and emergency preparedness.

8. Energetics

Insist on calorimetric testing to determine the stability of components, heats of reaction, potential for decomposition 

and potential magnitude of thermal runaways. Most adverse events in chemical processing occur because of poorly 

understood chemical reactivity or insufficient heat removal.

9. Batch record

Create a written batch record (batch log sheet) for each batch you conduct, even at kilo-scale. Master records should be 

reviewed and signed by representatives of the departments involved (R&D, Engineering, etc.). Document change control 

is particularly important to track revisions and ensure that the most recent version is in use.

10. Raw material grade

Conduct development experiments using technical-grade raw materials, or materials obtained directly from proposed

 large-scale suppliers. They will be more representative of future manufacturing sources.

11. Raw-material use test

Always perform a lab-scale use test using the actual lots of all raw materials and in-house intermediates earmarked for 

the pilot batch. Ensure that the product made meets specifications before proceeding with the scale-up. If a pilot batch 

later gives unexpected results, you'll be able to eliminate raw materials as a source of the problem.

12. Seize the opportunity

Make the maximum use of each batch. Take as many in-process samples as practical and retain them for later

 troubleshooting. This includes key effluent streams. Use the opportunity to collect mass balance data, to test your 

energy balance relationships, and to verify analytical methods. Document all significant details in a campaign or batch

 report to make the information readily accessible at a later date.

12 things to avoid

1. Keep it simple

Avoid reactions that require highly specialized equipment, or that are known to be hazardous and require special safety 

facilities, such as nitration reactions. At a minimum, obtain full calorimetric data and compare them to the maximum heat 

removal rate of the reactor. 

If necessary, consider outsourcing (tolling) such reactions to companies that specialize in them.

2. Heating

Never heat a reactor without agitation. It can create hot spots that can erupt into violent boiling when the mixer is turned 

on or initiate unexpected decomposition. Never stop the agitator until a reaction mixture has cooled to a safe temperature.

3. Decomposition

Do not operate a reactor at a temperature within 50°C of the known onset temperature of an exothermic decomposition 

reaction that might run out of control.

4. Solids addition

Avoid having to add solid reagents to a reacting mixture. Manual addition can be extremely dangerous, and while screws, 

conveyors and other apparatus for contained largescale solids addition are available, they are often unreliable and expensive. 

Similarly, do not add solids to a hot or refluxing mixture.

5. Evaporation

Do not develop a process that relies on the common laboratory technique of evaporating to dryness or to very low volumes.

 Most large-scale reactors have a minimum stir volume of about 20% of their capacity.

6. Exotherms

Try to avoid "all in and heat" operation (adding all reagents to the vessel and then heating up). 

Because of diminished heat-removal capacity at large scale, exothermic reactions can cause a thermal runaway. 

Exothermic decomposition reactions may follow, putting the reaction beyond any chance of operator control.

 Rapid gas evolution can compound the problem. It is better to design reactions so they can be controlled by 

slow addition of a limiting reagent at a rate that matches the equipment's cooling capacity. As a corollary to this rule, 

never add a catalyst to a reaction mixture last.

7. Timing

7. Timing

Avoid reactions that must be worked up or isolated "immediately," such as the kinetic resolution of some enantiomers. 

At commercial scale, many operations can take orders of magnitude longer than in the lab. Solid product isolation alone 

can take 24 hours or longer. For this reason, try to ensure that the product slurry or the stream of interest is stable for a 

sufficient length of time.

8. Solvents

Avoid using solvents that are considered environmental hazards or that may not be permitted in human pharmaceuticals,

 etc., such as méthylène chloride or other halogenated compounds. Beyond permitting difficulties, waste treatment or 

removal costs at manufacturing scale can often make a process uneconomical.

9. Filtration

Avoid hot filtrations or polish filtrations of highly saturated solutions. Solids can crash out quickly in pipes or lines and 

clog the filter or other equipment. To prevent this in the plant, lines often have to be steam-traced or preheated.

10. Extractions

Try to avoid reverse phase splits (where the upper phase goes to waste). Such operations require the addition of another 

vessel to the equipment train, a considerable expense at the manufacturing scale, and add time to the process cycle. 

Likewise, when quenching reactions 

with water, remember that at large scale, it is most common to add the quench to the batch and not the other way around.

11. Chromatography

Try to avoid using flash chromatography for purification. While useful in the lab, it is used commercially only for very-high-value

 products or where there is no other choice. Even then, chromatography requires very large amounts of solvents and 

support material. 

It is better to develop a salt or other crystalline form.

12. Play it safe

Don't risk all of your limited raw materials or intermediates on one batch! Be prepared for the possibility that the batch,

 especially in a new process, may still hold surprises in spite of your careful preparations. 

Operator errors or errors in the batch record are also more likely

 the first time through a new process.

SCALEUP OF ORGANIC PROCESSES

site for SCALEUP used in organic synthesis, part of main page shown below





PAGE CREATED BY DR ANTHONY MELVIN CRASTO M.SC, PH.D (ORGANIC 
CHEMISTRY,
29+ years experience in the field of research and development
email  amcrasto@gmail.com

Ентоні  アンソニー  Αντώνιος  安东尼    แอนโทนี   Энтони   אַנטאַני  
Антхони  एंथनी  안토니  أنتوني


 
NAME: DR. ANTHONY MELVIN CRASTO. 

Principal scientist, GLENMARK-GENERICS LTD

Navi mumbai, INDIA

Email  amcrasto@gmail.com

 

MOBILE+91-9323115463
TWITTER-   @amcrasto


web links




Anthony in different languages
  安东尼    Энтони    एंथनी  안토니   


CoSponsor(s): Pilot Plants (12b)
Pharmaceuticals (15b)
12:30 PM  
Welcoming Remarks
12:35 PM 77a
Scale-up Challenges and Considerations In the Process Development of An
Exothermic Reaction Step In Active Pharmaceutical Ingredient (API) Synthesis
Sanjeev Katti, Vitaly Nivorozhkin, Amy Baldwin
1:00 PM 77b
Effective Control of Residual Solvents In API Drying Using Fluid Bed Dryer
Yubo Yang, Ilaria Popolla, Melissa Kono
1:25 PM 77c
Minimizing Particle Agglomeration during Agitated Drying
William Bartels, Jose E. Tabora, John Wasylyk, Jessica Defreese, Prashant
Deshpande
1:50 PM 77d
Development of a Metals Removal Process for An Early Stage Active
 Pharmaceutical Ingredient (API) Process for Scale-up at the Pilot Plant Scale
Jason Hamm, Maxime Soumeillant, Susanne Kiau
2:15 PM 77e
Are High Throughput Technologies Useable for Engineering Scalability?
Robert Worth, Katarina Novakovic, Mark Willis, Allen R. Wright

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ANTHONY MELVIN CRASTO

THANKS AND REGARD'S
DR ANTHONY MELVIN CRASTO Ph.D

amcrasto@gmail.com

MOBILE-+91 9323115463
GLENMARK SCIENTIST ,  INDIA
web link
http://anthonycrasto.jimdo.com/
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