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univ of wisconsin-madisomResearch Groups
Biomimetic and total synthesis, and beta-lactam biosynthesis.
Development of radical methodology, fluorous tagging systems, and total synthesis.
Enantioselective synthesis, organophosphorus chemistry, organic chemistry of Main Group elements and the synthesis of medium rings and small multicyclic heterocycles.
Stereoselective synthesis of bicyclic and polycyclic structures.
Devise, develop, and apply new ideas in organic chemistry to the efficient synthesis of interesting molecules, particularly natural products with medicinal applications.
Research on natural product synthesis. Includes information on tandem and cascade reactions and new synthetic methods.
Combinatorial chemistry and the total synthesis of complex natural products.
Provides information on research interests including the total synthesis of biologically active natural products. Lists recent publications and current group members.
Chemistry of natural products. Chemical carcinogenesis. Mechanisms of biologically important reactions. Synthesis of farmacologically active compounds. Hemisynthesis. Computational organic chemistry. Development of new synthetic methods and reagents for organic synthesis.
Synthetic organic and organometallic chemistry.
Useful information to the chemical community that is relevant to research and teaching activities.
Design, synthesis, and evaluation of small molecule libraries. A particular emphasis is placed on therapeutically important receptor or enzyme classes that require the development of new combinatorial design strategies and/or synthesis chemistry.
Synthesis of biologicaly active and structurally complex natural products and the development of new reaction methodology.
Stereoselective organic reactions, synthesis of enantiomerically pure compounds and natural product syntheses.
Research is focused on the chemistry, biology, and medicine of natural and designed molecules.
Design of new reactions and reagents. Catalysis. New synthetic strategies towards complex natural products. Targets include b-lactam antibiotics, ionophores, steroids and related compounds, alkaloids, nucleosides, carbohydrates, and macrolide, terpenoid, and tetracyclic antitumor and antibiotic agents.
Catalytic antibodies, combinatorial chemistry, enzyme inhibition and immunophamacotherapy.
Catalytic antibodies, organocatalysis, protein-like DNA enzymes, therapeutic antibodies, molecular recognition of DNA by proteins, phage display.
Exploitation of strained, compact heterocycles. Manipulation of oxirane, oxetane and enol cyclic ether moieties for the synthesis of natural products and analogs of biological importance.
Functional Genomics through chemical and biological diversity. Synthesis and evaluation of natural products that we believe have RNA as their primary cellular target.
Discover, develop and understand new transition metal-catalyzed reactions.
Our research is designed to rationalize organic reactivity of heterocycles in terms of their chemical structures. This enables us to develop novel improved synthetic methods for the synthesis of a wide variety of classes of organic compounds.
Applications of organometallic chemistry to problems in materials deposition, methodology for organic synthesis, and catalysis.
Synthesis and properties of novel and biologically important polyaza heterocycles, tandem cascade chemistry, applications of the Pummerer reaction for heterocyclic synthesis, alkaloid chemistry and the cyclization reactions of metallo carbenoids for organic synthesis.
Exploiting organic and organometallic chemistry to solve problems in materials science and biology.
Lewis and BrÃ¸nsted acid catalysts of super reactivity and selectivity for various organic transformations (Designer Acid Catalysis)
Discovery of new reaction methodology and bioorganic chemistry.
Discovery of new metal-catalyzed reactions, investigation of their mechanisms and, based on these new reactions, development of novel methodologies for synthetic organic chemistry.
Total synthesis, asymmetric synthesis and bio-inorganic and medicinal chemistry.
Asymmetric synthesis, natural product total synthesis, organometallic and coordination chemistry, ligand design, polymerization, methodology development, catalysis, enantioselective synthesis, non-natural amino acid synthesis.
Organopalladium and polymer research.
Development of new synthetic routes to structurally diverse phosphorus- and sulfur-containing small molecules that will serve as building blocks for the synthesis of novel pharmaceutical agents and various natural products.
Development of new synthetic techniques, total synthesis, and the study of peptidomimetics.
Development of new asymmetric reactions and chiral catalysts.
Synthetic methodolgy, vitamin D analogs, antimalarial peroxide drugs.
Design and synthesize complex molecules that exhibit specific recognition properties, to develop methods to characterize molecular aggregates, and provides insights into non-covalent interactions in aqueous solution.
Enantioselective total synthesis of various natural and unnatural products of medicinal interest.
Total synthesis, design and synthesis of molecular devices, molecular recognition and the process of self-assembly.
Development of new reactions.
Synthesis of enamide and related natural products, synthesis of natural and unnatural epoxyquinoids, parallel synthesis and combinatorial chemistry.
Synthesis of natural products and small molecules to study biological processes, Transcriptional and translational control of protein synthesis, Molecular control of cellular signaling processes.
Enantioselective laboratory synthetic route(s) to the tetracycline antibiotics.
Synthetic and mechanistic organometallic chemistry and catalysis.
Natural products synthesis, organometallic chemistry, phenylenes, fullerenes and nanostructures.
Design and total synthesis of complex molecules and their application to biological problems, especially in molecular neurobiology and immunology.
Development of catalysts and catalytic reactions and methods for organic synthesis.
Chemistry, bioorganic chemistry of marine natural products with novel structural and biological properties.
Organic synthesis, synthetic methodology, lipid and polymer applications in drug delivery, gene therapy.
Development of new stereoselective carbon-carbon bond-forming processes and employing these methods in organic synthesis
Synthetic methodology and materials chemistry.
Discovery and application of new reactions for organic synthesis.
Applied enzymology/biocatalysis. Chemistry of nitric oxide.
Development of new synthetic methodology and new synthetic strategies and their application to the total synthesis of biologically active and structurally novel natural products.
New catalytic organic and organometallic transformations, their mechanism studies and their ultimate application to the total synthesis of architecturally challenging and biologically important natural products.
Electrophilic pi-allyl palladium complexes and nucleophilic sigma-allyl indium complexes.
Synthesis of Azaspiracid, Amphidinolide B1, Vacidin A and TMC-95A.
Design of new methods and catalysts for use in organic synthesis.
Natural product synthesis, bioorganic chemistry and materials science.
Design and development of new asymmetric catalysts and the application of these catalysts to the synthesis of useful chiral building blocks.
Synthetic organic, inorganic and organometallic chemistry, transition metal catalyzed asymmetric reactions for the Synthesis of biologically active compounds, biomimetic chemistry, molecular recognition and material chemistry.
Organic synthesis, bioorganic chemistry, medicinal chemistry and chemical biology.
Organic synthesis, natural products, combinatorial libraries, chemical sensors and biology.
Structure elucidation, total synthesis, and determination of the mode of action of marine natural products that display significant physiological activity.
Syntheses of natural and unnatural products that are of biological or structural interest.
Total synthesis, catalytic reaction development, organometallic chemistry and self-assembly.
Asymmetric catalysis, organic synthesis and organometallic chemistry.
Coordination chemistry, organometallic chemistry and organic synthesis.
Identification of natural products with interesting, often novel, structures and useful biological properties that may lead to medicinal agents for treatment of cancer, cardiovascular disorders and infectious diseases.
Molecular glycosciences: complex glycoconjugate synthesis and carbohydrate-based molecular recognition.
Biomolecular recognition processes: the chemistry and biology of protein-saccharide interactions.
Synthetic methodology, total synthesis and bioorganic chemistry.
Interactions of oligosaccharides with proteins that control cell growth, cell differentiation, cell-cell interactions, bacterial attachment to target cells and signaling events involving the extracellular matrix.
Asymmetric synthesis of biologically active, stereochemically complex, natural products.
Synthesis and evaluation of glycosidase inhibitors, synthesis and characterisation of cellulose analogues, synthesis and evaluation of pairing properties of novel DNA and RNA analogues.
Total synthesis and development of new reaction methods.
Total synthesis. Medicinal chemistry and drug design. Immunochemistry and drug targeting. Glycosidic linkage in life processes. Computer aided chemistry and molecular modeling.
Bioorganic and natural products chemistry.
Glycosaminoglycans and fucosyl saccharides. Dynamic glycosylation.
Synthetic macromolecular chemistry, supramolecular chemistry and material sciences.
Design and synthesis of new molecules with interesting properties.
Bioorganic chemistry of vision, configurational studies by circular dichroism, neuromodulatory effects of ginkgolides.
Asymmetric catalysis. Selective C- C bond formation and cleavage. Enzymatic oxidations. Mimics of physiologically important enzymes. New approaches to catalyst design.
Organic synthesis, NMR spectroscopy, computational chemistry, ecology, microbiology and biochemistry.
New synthetic methodology, asymmetric synthesis, natural product synthesis, and new materials.
Synthesis and use of pyrrole-containing molecules.
Organic synthesis and medicinal chemistry, transition metal catalysis, organophosphorus chemistry, parallel synthesis, drug discovery.
Mechanistic organic photochemistry, organosilicon photochemistry.
Novel aromatics: nonplanar aromatic compounds, cyclophanes and molecular switches.
Organic chemistry, materials and catalysis.
Synthetic methodology. Synthesis of bioactive molecules and natural products. Aromatic and heteroaromatic synthesis directed ortho metalation. Transition metal cross coupling. Ferrocene and BINOL ligands for asymmetric synthesis.
Molecular encapsulation, self-assembling structures, de novo design of proteins organized by organic macrocycles.
Peptide mimicry. Combinatorial chemistry. Biologically active peptides. Amino acids ligands for neuroscience. Solid-phase chemistry.
Structural, synthetic, medicinal, and functional organic chemistry.
Synthetic organic chemistry. Medicinal chemistry. Asymmetric methodology.
Functional genomics and proteomics, cell biology, virology, signal transduction, molecular mechanisms, chemical synthesis.
Photochemistry. Kinetics and mechanisms of organic reactions.
Asymmetric synthesis and total synthesis.
Organoboron chemistry. Transition metal and lanthanide catalysis. Cycloadditions. Reactive intermediates. Heterocycles and guanidines. Combinatorial chemistry.
Organic synthesis. Asymmetric catalysis. Organometallic chemistry.
Mechanistic organometallic chemistry and organic synthesis.
Total synthesis and asymmetric catalysis.
Bioinorganic chemistry, natural products synthesis and synthetic methodology.
Organometallic chemistry, mechanistic organic chemistry, combinatorial chemistry and organic synthesis.
New reactions involving nickel catalysis.
[3+3] cycloaddition reactions and chiral variants of allenamines and ynamines.
Syntheses of architecturally unique natural products and protein reactive natural products.
Development of stereoselective catalytic carbonylation reactions - a new and highly effective synthesis of aldols and aldol-derived structures. Total synthesis of macrolide antibiotics and polyol-derived natural products.
C-H Bond functionalization in complex organic synthesis, chemical probes for covalent protein modification and imaging of metabolic/signaling pathways.
Catalytic enantioselective processes of broad utility to organic and medicinal chemists.
Flourine chemistry, fluoroolefin peptidomimetics, precursor design for the chemical vapor deposition of metals, catalyst systems for the syndiotactic polymerization of styrene, pyrazinamide, analogs and the mechanism of action of an antituberculous agent.
Natural product synthesis, Prins cyclization, reductive decyanation, chiral auxiliaries for oxocarbenium ion reactions and methods for predicting molar rotations of acetonides.
Organometallic chemistry, AIDS-related research, Vancomycin biaryl, new BINOLs, NOBINs, and BINAPs and cyclopeptide Alkaloids.
Organic synthesis of natural products, and related artificial functional molecules; molecular recognition and mechanism of interactions between these molecules and biopolymers.
Synthesis of bioactive and other structurally interesting materials.
Total synthesis of cytotoxic marine and microbial natural products.
Development of new synthetic methodology using novel main-group organometallic chemistry.
Development of new catalytic processes for asymmetric synthesis. Development of new methodology and its applications in synthesis. Total synthesis of biologically important targets.