Curriculum Vitae

Neurologist MSc PhD

EDUCATION

Doctorate (PhD) in Neuroinformatics

University of Patras Medical School  (2009-2016)

Resident in Neurology

Eginiteion Hospital (2013-2017)

Attica Psyciatric Hospital “Dafni” (2009)

Corfu General Hospital “St. Irini” (2008)

Graduate Diploma (MSc) in

Informatics for Life Sciences: Neuroinformatics (Grade: Excellent)

University of Patras Medical School (2005 – 2009)

Diploma of Medicine (Grade: Very Good – 7.11 / 10)

          Athens Medical School (1998 – 2005)

Secondary Education

1st Lyceum of Vrilissia, Athens (Graduation 1998)


RESEARCH INTERESTS

Signal analysis of EEG and MEG

Experience using custom built MATLAB software with time-frequency analysis, topography, event-related averaging, independent component analysis and other basic techniques, in the Neurophysiology Unit of the University of Patras (since 2006). [MSc Thesis, Publications 2-7, Announcements 1, 2, 5, 6, 7, 9-14]

Brain rhythms in sleep and epilepsy

Research on human brain EEG rhythm interactions during normal sleep and their relation to epileptic syndromes, as the subject of the PhD thesis (since 2009) under the supervision of Prof. George K. Kostopoulos. [Publications 4-7, Announcements 3, 4, 9, 10, 12, 14]

Epilepsy Surgery

Use of EEG and ECoG in the context of presurgical evaluation as a means to identify the epileptogenic zone. Clinical experience in epilepsy surgery centers (2008-2009). [Announcements 8, 11, 13]

Neuron modeling: Single-cell and network models, Synaptic plasticity

Experience with simple leaky integrator models in the context of the MSc in Neuroinformatics (2006).

Fuzzy Logic and Artificial Intelligence

Work with fuzzy logic for decision support systems in the context of the MSc in Neuroinformatics in collaboration with the department of Computer Engineering and Informatics of the University of Patras (2006). [Publication 1]


PUBLICATIONS

Peer Reviewed Articles

  1. HEPAR: An Intelligent System for Hepatitis Prognosis and Liver Transplantation Decision Support, Constantinos Koutsojannis, Andrew Koupparis, Ioannis Hatzilygeroudis, in “Tools and Applications with Artificial Intelligence”, Studies in Computational Intelligence Series, Vol. 166, Koutsojannis, C., Sirmakessis, S. (Eds.) , Springer, 2009, doi:10.1007/978-3-540-88069-1_13
  2. The Hypnospectrogram: an EEG power spectrum based means to concurrently overview the macroscopic and microscopic architecture of human sleep, Kokkinos V, Koupparis A, Stavrinou ML, Kostopoulos GK, Journal of Neuroscience Methods 2009, doi:10.1016/j.jneumeth.2009.09.002
  3. V Kokkinos, M Koutroumanidis, K Tsatsou, A Koupparis, D Tsiptsios, C Panayiotopoulos, Multifocal spatiotemporal distribution of interictal spikes in Panayiotopoulos syndrome, Clinical Neurophysiology, 2010,  doi:10.1016/j.clinph.2010.01.019.
  4. Vasileios Kokkinos, Andreas Koupparis, Maria Stavrinou, Kyriakos Garganis, George Kostopoulos, Sleep spindle alterations following-up a childhood absence epilepsy case, Epileptologia 2011; 19(2): 73-83 [PDF]
  5. Andreas Koupparis, Vasileios Kokkinos, George K Kostopoulos, Spindle Power Is Not Affected after Spontaneous K-Complexes during Human NREM Sleep, PLoS ONE 8(1): e54343, 2013, doi:10.1371/journal.pone.0054343
  6. V Kokkinos, AM Koupparis, D Tsiptsios, GK Kostopoulos, M Koutroumanidis, Spatiotemporal profiles of focal and generalised spikes in childhood absence epilepsy, Epileptic Disorders 2013, 15 (1), 14-26, doi:10.1684/epd.2013.0561
  7. V Kokkinos, AM Koupparis, GK Kostopoulos, An intra-K-complex oscillation with independent and labile frequency and topography in NREM sleep, Frontiers in Human Neuroscience 7, 163, doi: 10.3389/fnhum.2013.00163
  8.  Koupparis, A. M., Kokkinos, V., & Kostopoulos, G. K. (2014). Semi-automatic sleep EEG scoring based on the hypnospectrogram. Journal of neuroscience methods, 221, 189-195. doi: 10.1016/j.jneumeth.2013.10.010
  9. Sakellariou, D., Koupparis, A.M., Kokkinos, V., Koutroumanidis, M., et al. (2016) Connectivity Measures in EEG Microstructural Sleep Elements. Frontiers in Neuroinformatics, doi:10.3389/fninf.2016.00005

Conferences

  1. K-Complexes modify Spindles during the Second Stage of NREM Human Sleep, V.Kokkinos, A.Koupparis, M.Stavrinou, A.Ioannides, G.Kostopoulos, in Proc. of the 21st Annual Meeting of the Hellenic Society for Neuroscience, Greece, pp. 120-121, Nov 2007
  2. The K-Complex initially blocks Fast Spindles and afterwards evokes Faster Spindles during Stage II of Human NREM Sleep, V.Kokkinos, M.Stavrinou, A.Koupparis, G.Kostopoulos, A.Ioannides, in Proc. of the Reseach in Encoding and Decoding of Neural Ensembles (AREADNE '08), Santorini, Greece, Jun 2008
  3. Whole-night Sleep EEG study of an 11 year-old with a history of Childhood Absence Epilepsy, V.Kokkinos, K.Garganis, A.Koupparis, M.Stavrinou, V.Zountsas, K.Kontogiannis, G.Kostopoulos, in Proc. of the 4th National Epilepsy Congress, Greece, Nov 2008
  4. Dynamics of brain rhythmogenesis in human sleep and their possible contribution to epilepsy, G. K. Kostopoulos, V. Kokkinos, A. Koupparis, M. Stavrinou, A. A. Ioannides, in Proc. of the 8th National Neuroscience Congress, Bolu, Turkey, Apr 2009
  5. Psiouri G, Stavrinou ML, Koupparis A, Kokkinos V and Kostopoulos GK (2009). Demonstration of MMN in human subjects after stimulation with two complex deviant sounds. Frontiers in Behavioral Neuroscience. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.264
  6. V Kokkinos, A Koupparis, ML Stavrinou, GK Kostopoulos, A sleep scoring and overnight brain-rhythm progression overview tool based on power spectral analysis of the EEG: the Hypnospectrogram , 23rd Meeting of the Hellenic Society for Neuroscience (2009)
  7. V Kokkinos, A Tsatsou, A Koupparis, D Tsipsios, C Panayiotopoulos, Panayiotopoulos Syndrome: An idiopathic and bening multifocal childhood epilepsy of the autonomous system, in Proc. of the 5th National Epilepsy Congress, Chania, Greece, Nov 2009
  8. A Ntinopoulos, E Lapa, M Tsirouda, A Koupparis, S Sgouros, Improvement of Epilepsy and electrical Status Epilepticus during sleep after surgical removal of a cortical epileptogenic nodule, in Proc. of the 5th National Epilepsy Congress, Chania, Greece, Nov 2009
  9. V.Kokkinos, A.Koupparis, M.L.Stavrinou, G.K.Kostopoulos, Interactions between NREM sleep stage II spindles and K-complexes, (oral presentation) in Proc. of Consciousness and its Measures Conference, Limassol, Cyprus, Nov 2009.
  10. V Kokkinos, AM Koupparis, G Damaskos, ML Stavrinou, GK Kostopoulos, A high-theta rhythm of fronto-posterior direction appears during the K-complex in NREM stage II of human sleep, in Proc. of the Research in Encoding and Decoding of Neural Ensembles (AREADNE '10), Santorini, Greece, Jun 2010
  11. F.Giannikopoulou, V.Kokkinos, A.Koupparis, GK.Kostopoulos. K.Garganis,  Topographic evaluation of the localizing ability of the extracranial EEG in temporal lobe lesions with extratemporal localization (greek), 6th Panhellenic Congress on Epilepsy, Thessaloniki, Greece, 2011
  12. M.L. Stavrinou, S. Kollia, A. Koupparis, P. Athanasopoulou, G. Damaskos, G.K. Kostopoulos, Motor skill learning correlates to increased REM sleep duration, 8th IBRO World Congress of Neuroscience, Florence- Italy, 2011
  13. F.Giannikopoulou, V.Kokkinos, A.Koupparis, GK.Kostopoulos. K.Garganis,  Topographical evaluation of extracranial EEG ability to localise lesions of temporal lobe, in temporal lobe epilepsy with extratemporal EEG features, 1st African Epilepsy Congress, Nairobi, 2012
  14. A Koupparis, V Kokkinos, GK Kostopoulos, Sleep spindles and spontaneous K-complexes interactions during human NREM sleep, 8th FENS Forum of Neuroscience, Barcelona, Spain, 2012 [PDF]
  15. 15. E.I. Zacharaki, E. Pippa, A. Koupparis, G.K. Kostopoulos, V. Megalooikonomou, Classification of EEG waveforms by spectral clustering, 5th Pan-Hellenic Conference on Biomedical Technology, Athens, April 4-6, 2013
  16. V Kokkinos, S Vulliemoz, AM Koupparis, UJ Chaudhary, R Rodionov, D Carmichael, M Koutroumanidis, GK Kostopoulos, L Lemieux, K Garganis, EEG-FMRI Of The Cyclic Alternating Pattern In Human NREM Sleep, 30th International Epilepsy Congress, Montreal, Canada, 23 – 27 June 2013
  17. E.I. Zacharaki, E. Pippa, A. Koupparis, V. Kokkinos, G. Kostopoulos, V. Megalooikonomou, Oneclass classification of temporal EEG patterns for K-complex extraction, 35th International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), pp. 5801-5804, Osaka, Japan, July 3-7, 2013.
  18. Andreas M Koupparis, Vasileios Kokkinos, George K Kostopoulos, EEG Sleep Scoring With A Semi-Automated Tool Based On K-means Clustering Of The Hypnospectrogram, 26th Meeting of the Hellenic Society for Neuroscience, November 29-December 1, 2013
  19. Dimitris Sakellariou, Andreas M. Koupparis, Vasileios Kokkinos, George K. Kostopoulos, Connectivity patterns of Sleep Microstructural Elements, 26th Meeting of the Hellenic Society for Neuroscience, November 29-December 1, 2013
  20. Sakellariou D, Koupparis A, Kokkinos V, Kostopoulos GK: Connectivity Patterns of Sleep Microstructural Elements, 19th International Conference on Biomagnetism, Halifax Canada, 24-28 August 2014
  21. C. Moshovos, G. Makridakis, A. Koupparis, E. Tsoukas, A. Bonakis, D. Pandis, A. Ghika, I. Evdokimidis, A. Kyrozis, Faster sleep spindles at the side of the epileptic focus in patients with temporal lobe epilepsy, 22nd Congress of the European Sleep Research Society, Tallinn, Estonia, September 2014
  22. Katsavos S, Xirou S, Koupparis A., Skarakis G, Totsika V, Koutsis G, Evangelopoulos ME, Andreadou E, Kilintireas K, Anagnostouli M, Presentation of CIS with single of multiple tumefective lesions: Differential diagnoses and treatment, 2nd interdepartmental Symposium on MS, Thessaloniki 22-23-24/5/2015
  23. Liti M., Zouridis J., Koupparis A., Kostopoulos GK., Spectral Analysis of Heart Rate: Implication for Sleep Classification, 6th Panhellenic Interdisciplinary Congress on Sleep Research, Athens, 7/2016
  24. Kostopoulos GK, Liu L, Poghosyan V, Kokkinos V, Koupparis AM, Zouridis J, Liti M and Ioannides AA (2016). MEG and EEG polysomnography studies explore the role of K-Complexes and related EEG rhythms in maintaining a sound and safe sleep. Front. Hum. Neurosci. Conference Abstract: SAN2016 Meeting. doi: 10.3389/conf.fnhum.2016.220.00111

THESIS

Study of EEG rhythms as a contribution to sleep physiology and pathophysiology of epileptic syndromes (PhD in Neuroinformatics) [view (greek)]

Design and implementation of a graphical user interface for the processing of EEG signal through MATLAB (MSc in Informatics for Life Sciences) [view (greek)]

AWARDS

  1. PhD Scholarship "Heracleitus II" (2009-2016)
  2. 2nd Award for the best poster presentation “Panayiotopoulos Syndrome: An idiopathic and bening multifocal childhood epilepsy of the autonomous system”, V Kokkinos, A Tsatsou, A Koupparis, D Tsipsios, C Panayiotopoulos, at the 5th National Epilepsy Congress, Chania, Greece (2009)
  3. 2nd Award from the Hellenic Society for Neuroscience for best poster presentation "K-Complexes modify Spindles during the Second Stage of NREM Human Sleep", V.Kokkinos, A.Koupparis, M.Stavrinou, A.Ioannides, G.Kostopoulos, at the 21st HSN Conference (2007)
  4. Scholarship of the Hellenic Ministry of Education in the context of the “Informatics for Life Sciences” Graduate Program (2005-6)
  5. Third Place at the 56th National Students Contest in Mathematics (1996)