Recinto Universitario de Mayaguez

Rodolfo J. Romañach, Ph.D.

Professor of Chemistry

Ph.D. University of Georgia 1986

Site Leader NSF ERC-SOPS

Current Graduate Students:

Eduardo Hernandez Torres

Barbara Alvarado

Carlos Ortega

Adriluz Sanchez Paternina

Maritza Reyna 

Mariana Leon

Jose Mercado

Pedro Martinez

Fabiola Semidei

Current Undergraduate students

Paola Flores

Nashaly Otero

Daniela M. Rivera

Mariandreina Gutierrez

Gustavo Linares

Research & Action:

Our group is dedicated to analyzing samples on an “as-is” basis without dissolving or affecting the sample. To achieve this goal we work with near infrared spectroscopy and collaborate with a wide scientific community. Most of our collaborations are with researchers from the Engineering Research Center for Structured Organic Particulate Systems (ERC-SOPS, and Janssen Ortho LLC in Gurabo, PR. We also work in close collaboration with Dr. Rafael Mendez from the UPRM Chemical Engineering Department who provides a very valuable particle engineering insight for the problems we attack. But our community has no bounds and extends to Catalunya, Copenhagen, and Cartagena, and we are always ready to expand.

I am very happy to be in this Department, and very grateful to those professors that gave me the opportunity. Times may be tough, but when the “going gets tough, the tough get going”; there are too many exciting contributions for us to do.  We have wonderful students, true rough diamonds for us to polish and make shine. We foresee many good opportunities, and are looking for new undergraduate and graduate students to join our group. We do not want to look back, only forward. 

Our research is progressing with the financial help of the National Science Foundation, Puerto Rico Science Technology and Research Trust, and Janssen Ortho LLC. 

 Analytical & Pharmaceutical Lab

Our group is called the Analytical & Pharmaceutical group since students are equally encouraged to learn about analytical chemistry and pharmaceutics, and present in both pharmaceutical and chemical meetings. Research is an important means for developing human resources in support pharmaceutical manufacturing.  The group's projects include innovative research efforts, and many activities to encourage the transfer of knowledge to pharmaceutical manufacturing sites. 

The mission of the Analytical & Pharmaceutical group is: “Facilitate the development and implementation of Quality by Design manufacturing by supplying scientists, Near Infrared and Raman Spectroscopic methods to the pharmaceutical industry”.

 Research (Process Analytical Technology)

Most analytical labs are distant from the manufacturing site that they service, and analyze samples after the manufacturing process is completed.  The analytical methods carried out by chemists indicate whether the product was manufactured according to the desired specifications.  However, analytical chemistry can be even more productive. The critical process parameters and conditions could be monitored as the process occurs, and this information could be used by chemical engineers to control the process and assure that all products comply with the desired requirements. This real time information could also be used to improve the process. The analytical lab can be embedded within a manufacturing plant, providing real time information to improve the process. This new approach to Quality Assurance and higher efficiency manufacturing processes is what FDA has termed Process Analytical Technology (PAT).

Future manufacturing should  be performed with sensors  to monitor and control manufacturing following PAT concepts.  Quality Control will then be a means for continuous improvement in manufacturing, and an element to increase manufacturing competitiveness.

Research efforts are carried out in collaboration with the NSF Engineering Center on Structured Organic Particulate Systems (, where I am part of the leadership Team, and work in collaboration with scientists from Rutgers, Purdue, NJIT, in efforts that involve researchers from the four universities. 

Our group also collaborates with two emeging companies located in Puerto Rico which are dedicated to providing service in the area of Process Analytical Technology and Quality by Design. 


 The Analytical & Pharmaceutical lab in the Chemistry Department that Dr. Romañach leads is well equipped for vibrational spectroscopy and data analysis. The laboratory includes:


  1. A MPA™ (Multipurpose Analyzer) from Bruker Optics, which is capable of obtaining near infrared transmission spectra for tablets.
  2. A Matrix FT-NIR system from Bruker Optics. 
  3. An Olympus CX-31 Polarized light microscope equipped with a photographic system.
  4. 870 Karl Fischer Titrino Plus system. 
  5. A UV-Vis spectrometer Evolution 60S from Thermo Instruments. 
  6. Accupic 1340 Automatic Gas pycnometer with 10 cm3 sample capacity for obtaining true, absolute, skeletal and apparent volume and density of powders. 

The lab is also well equipped for multivariate analysis. Our group also has Simca chemometrics software , and the MODDE experimental design software. IThe group also uses the MATLAB based PLS toolbox developed by Eigenvector Research, and Unscrambler 10.3 developed by CAMO.  Finally, our lab is also well equipped with basic equipment such as a planetary shaker, sonicator, centrifuge, and an O’Haus Analytical Balance. 


UPR-Mayagüez was the first University where the great potential of Near Infrared Spectroscopy was first recognized by Dr. Owen H. Wheeler, who taught in our University from 1958 – 1976 and who wrote the following articles:

    O.H. Wheeler, Near Infrared Spectra of Organic Compounds, 1959, Chem. Rev., 629 – 666.

    O.H. Wheeler, Near Infrared Spectra A neglected field of Study, Journal of Chemical Education, 1960, 37(5), 234 -236.

Complete List of Publications:

Esbensen, K. H.; Romañach, R. J.; Román-Ospino, A. D., Chapter 4 - Theory of Sampling (TOS): A Necessary and Sufficient Guarantee for Reliable Multivariate Data Analysis in Pharmaceutical Manufacturing A2 - Ferreira, Ana Patricia. In Multivariate Analysis in the Pharmaceutical Industry, Menezes, J. C.; Tobyn, M., Eds. Academic Press: 2018; pp 53-91.

Sierra-Vega, N. O.; Sánchez-Paternina, A.; Maldonado, N.; Cárdenas, V.; Romañach, R. J.; Méndez, R., In line monitoring of the powder flow behavior and drug content in a Fette 3090 feed frame at different operating conditions using Near Infrared spectroscopy. J. Pharm. Biomed. Anal. 2018, 154, 384-396.

Romañach , R. J.; Sanchez-Paternina, A.; Esbensen, K. H., Variographic Analysis of 1-D lots in Pharmaceutical Manufacturing (Powder Mixing). American Pharmaceutical Review 2018, 21 (1), 22-26.

Vargas, J. M.; Nielsen, S.; Cárdenas, V.; Gonzalez, A.; Aymat, E. Y.; Almodovar, E.; Classe, G.; Colón, Y.; Sanchez, E.; Romañach, R. J., Process analytical technology in continuous manufacturing of a commercial pharmaceutical product. Int. J. Pharm. 2018, 538 (1–2), 167-178.

Hausner, D. B.; Romañach , R. J., Progress Towards Advanced Pharmaceutical Manufacturing. American Pharmaceutical Review 2017, 20 (July-August), 54-57.

Romañach , R. J. In Theory of Sampling - From Missing Link to Key Enabler for Process Analytical Technology (PAT), 8th World Conference on Sampling and Blending, Perth, Australia, May 9- 11, 2017; Australian Institute of Mining and Metallurgy: Perth, Australia, 2017; pp 63-68.

Pinzon de la Rosa, C.; Rodriguez, V.; Hormaza, M. L.; Romañach , R. J. In TOS MEETS THE NSF I-CORPS™ PROGRAM, 8th World Conference on Sampling and Blending, Perth, Australia, Australian Institute of Mining and Metallurgy: Perth, Australia, 2017; pp 351-354.

Vargas, J. M.; Roman-Ospino, A. D.; Sanchez, E.; Romañach, R. J., Evaluation of Analytical and Sampling Errors in the Prediction of the Active Pharmaceutical Ingredient Concentration in Blends From a Continuous Manufacturing Process. J Pharm Innov 2017, 12 (2), 155–167.

Ortega-Zuñiga, C.; Reyes-Maldonado, K.; Méndez, R.; Romañach, R. J., Study of near infrared chemometric models with low heterogeneity films: The role of optical sampling and spectral preprocessing on partial least squares errors. J. Near Infrared Spectrosc. 2017, 25 (2), 103-115.

Colón, Y. M.; Vargas, J.; Sánchez, E.; Navarro, G.; Romañach, R. J., Assessment of Robustness for a Near-Infrared Concentration Model for Real-Time Release Testing in a Continuous Manufacturing Process. J Pharm Innov 2017, 12 (1), 14-25.

Cárdenas, V.; Roman Ospino, A.; Romañach, R. J., Recent Advances in Obtaining Process Information from Near Infrared Spectra. American Pharmaceutical Review 2016, 19 (7), 22-25.

Romañach , R. J.; Esbensen, K. H., Theory of Sampling (TOS) - for Development of Spectroscopic Calibration Models American Pharmaceutical Review 2016, 19 (6), 138-139.

Román-Ospino, A. D.; Singh, R.; Ierapetritou, M.; Ramachandran, R.; Méndez, R.; Ortega-Zuñiga, C.; Muzzio, F. J.; Romañach, R. J., Near infrared spectroscopic calibration models for real time monitoring of powder density. 
International Journal of Pharmaceutics 2016, 512 (1), 61-74.

Banquet-Terán, J.; Johnson-Restrepo, B.; Hernández-Morelo, A.; Ropero, J.; Fontalvo-Gomez, M.; Romañach, R. J., Linear and Nonlinear Calibration Methods for Predicting Mechanical Properties of Polypropylene Pellets Using Raman Spectroscopy. Appl. Spectrosc. 2016, 70 (7), 1118-1127.

Romañach, R. J., Independence and Dependence in Calibration: A Discussion of FDA and EMA Guidelines. American Pharmaceutical Review 2016, 19 (4), 46-49.

Osorio, J. G.; Hernández, E.; Romañach, R. J.; Muzzio, F. J., Characterization of resonant acoustic mixing using near-infrared chemical imaging. Powder Technol. 2016, 297, 349-356. 

Hernández, E.; Pawar, P.; Rodriguez, S.; Lysenko, S.; Muzzio, F. J.; Romañach, R. J., Effect of Shear Applied During a Pharmaceutical Process on Near Infrared Spectra. Appl. Spectrosc. 2016, 70 (3), 455-466.

Sánchez-Paternina, A.; Román-Ospino, A. D.; Martínez, M.; Mercado, J.; Alonso, C.; Romañach, R. J., Near infrared spectroscopic transmittance measurements for pharmaceutical powder mixtures.
J. Pharm. Biomed. Anal. 2016, 123, 120-127.

Romañach, R., Near infrared spectroscopy: from feasibility to implementation in the pharmaceutical industry. NIR news 2016, 27 (1), 33-38.

Esbensen, K. H.; Román-Ospino, A. D.; Sanchez, A.; Romañach, R. J., Adequacy and verifiability of pharmaceutical mixtures and dose units by variographic analysis (Theory of Sampling) – A call for a regulatory paradigm shift. Int. J. Pharm. 2016, 499 (1–2), 156-174.

Hernandez, E.; Pawar, P.; Keyvan, G.; Wang, Y.; Velez, N.; Callegari, G.; Cuitino, A.; Michniak-Kohn, B.; Muzzio, F. J.; Romañach, R. J., Prediction of dissolution profiles by non-destructive near infrared spectroscopy in tablets subjected to different levels of strain. Journal of Pharmaceutical and Biomedical Analysis 2016, 117, 568-576.  

Palma, F.; Michniak-Kohn, B.; Pérez-Correa, J. R.; Hernandez, E.; Romañach, R. J.; Valenzuela, L. M., Near-infrared chemical imaging and its correlation with the mechanical properties of chitosan–gelatin edible films. Carbohydrate Polymers 2016, 136, 409-417.

Romañach, R.; Román-Ospino, A.; Alcalà, M., A Procedure for Developing Quantitative Near Infrared (NIR) Methods for Pharmaceutical Products. In
Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture, Ierapetritou, M. G.; Ramachandran, R., Eds. Springer New York: 2016; pp 133-158.

Singh, R.; Román-Ospino, A. D.; Romañach, R. J.; Ierapetritou, M.; Ramachandran, R., Real time monitoring of powder blend bulk density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process. International Journal of Pharmaceutics 2015, 495 (1), 612-625. 

, P. J.; Romañach, R. J.; Abatzoglou, N.; Rielly, C. D., Pharmaceutical Blending and Mixing. John Wiley & Sons, Ltd: 2015; p 512

Osorio, J. G.; Vanarase, A. U.; Romañach, R. J.; Muzzio, F. J., Continuous Powder Mixing.
In Pharmaceutical Blending and Mixing, John Wiley & Sons, Ltd: 2015; pp 101-127.
Romañach, R. J., Sampling and Determination of Adequacy of Mixing. In Pharmaceutical Blending and Mixing, John Wiley & Sons, Ltd: 2015; pp 57-78

, J.; Ying, Y.; Pielecha-Safira, B.; Bilgili, E.; Ramachandran, R.; Romanach, R.; Dave, R. N.; Iqbal, Z., Raman spectroscopy for in-line and off-line quantification of poorly soluble drugs in strip films. International Journal of Pharmaceutics 2014, 475 (1-2), 428-437.

Romañach, R. J.; Hernández Torres, E.; Roman Ospino, A.; Pastrana, I.;
Semidei, F., NIR and Raman Spectroscopic Measurements to Train the Next Generation of PAT Scientists. American Pharmaceutical Review 2014, 17 (6), 82-87.

Romañach, R., IDRC-17—Opening our minds to our legacy and new ideas.
NIR news 2014, 25 (6), 19-21.

Prats-Montalbán, J.; Jerez-Rozo, J.;
Romañach, R.; Ferrer, A., Multivariate image analysis and near infrared chemical imaging for characterisation of micro-mixing in polymeric thin films. NIR news 2014, 25 (6), 4-7

Colón, Y. M.;
Florian, M. A.; Acevedo, D.; Mendez, R.; Romanach, R. J., Near Infrared Method Development for a Continuous Manufacturing Blending Process. J Pharm Innov 2014, 9 (4), 291-301.

-Ortiz, D.; Colon, Y.; Romanach, R. J.; Mendez, R., Analysis of powder phenomena inside a Fette 3090 feed frame using in-line NIR spectroscopy. J Pharm Biomed Anal 2014, 100, 40-49.

Romañach, R., IDRC-17 (Chambersburg), 2–8 August 2014. NIR news 2014, 25 (4), 23-25

Cebeci-Maltaş, D.; McCann, R.; Wang, P.; Pinal, R.; Romañach, R.; Ben-Amotz, D., Pharmaceutical Application of Fast Raman Hyperspectral Imaging with Compressive Detection Strategy.
J Pharm Innov 2014, 9 (1), 1-4.

Fontalvo-Gomez, M.; Colucci, J. A.; Velez, N.; Romanach, R. J., In-Line Near-Infrared (NIR) and Raman Spectroscopy Coupled with Principal Component Analysis (PCA) for In Situ Evaluation of the Transesterification Reaction. Applied spectroscopy 2013, 67 (10), 1142-1149.

Boada-Lopez, J.; DeJesus-Maldonado, I.; Jerez, J.; Romañach, R.; Diffoot-Carlo, N.; Sundaram, P., Collagen abundance in mechanically stimulated osteoblast cultures using near infrared microscopy. Journal of Biomechanics 2013, 46 (14), 2442-2450.

Susarla, R.; Sievens-Figueroa, L.; Bhakay, A.; Shen, Y. Y.; Jerez-Rozo, J. I.; Engen, W.; Khusid, B.; Bilgili, E.; Romanach, R. J.; Morris, K. R.; Michniak-Kohn, B.; Dave, R. N., Fast drying of biocompatible polymer films loaded with poorly water-soluble drug nano-particles via low temperature forced convection.
International Journal of Pharmaceutics 2013, 455 (1-2), 93-103. 

C. Beck, L. Sievens-Figueroa, K. Gärtner, J. I. Jerez-Rozo, A. Bhakay, R. J. Romañach , B. Michniak-Kohn , and R. N. Davé "Effects of stabilizers on particle redispersion and dissolution from polymer strip films containing Liquid Antisolvent precipitated griseofulvin particles”, Powder Technology, 2013, 236, 37 - 51. 

Alcalà, M., Blanco, M., Menezes, J. C., Felizardo, P. M., Garrido, A., Pérez, D., Zamora, E., Pasquini, C. and Romañach, R. J. 2012. Near-Infrared Spectroscopy in Laboratory and Process Analysis. Encyclopedia of Analytical Chemistry. Online ISBN: 9780470027318. DOI: 10.1002/9780470027318.a9361  

K.A. Court, J. Jerez, R.J. Romañach, M. Torres-Lugo, Particle Encapsulation in Cross-linked Hydrogel Networks: Particle Distribution Optimization, Journal of Materials Science and Engineering, 2012, B2(10), 539- 550. 

R.J. Romañach, Group Profile: Analytical & Pharmaceutical Group: University of Puerto Rico, NIR News, 2012, 23(6), 18 – 21, doi:10255/nirn.1325. 

David Acevedo, Ariel Muliadi, Arun Giridhar, James D. Litster, Rodolfo J. Romañach,  “Evaluation of Two Approaches for Real Time Monitoring of Roller Compaction with Near Infrared Spectroscopy”, AAPSPharmscitech, 2012, 13(3), 1005 – 1012.

 José M. Prats-Montalbán, Jackeline I. Jerez Rozo, Rodolfo J. Romañach, Alberto Ferrer,  MIA and NIR Chemical Imaging for pharmaceutical product characterization, Chemometr. Intell. Lab. Syst., 2012, 117, 240-249.

  Sievens-Figueroa, A. Bhakay; J.I Jerez-Rozo; N. Pandya; R. Romañach; B. Michniak-Kohn ; Z. Iqbal; E. Bilgili; R.N Davé,  Preparation and characterization of hydroxypropyl methyl cellulose films containing stable BCS Class II drug nanoparticles for pharmaceutical applications, International Journal of Pharmaceutics, 2012, 423, 496 – 508.   

J.I. Jérez-Rozo, A. Zarow, B. Zhou, R. Pinal, Z. Iqbal, R.J. Romañach, “Complementary Near and Chemical Imaging of Pharmaceutical Thin Films”, Journal of Pharmaceutical Sciences, 2011, 100(11), 4888 – 4895. 

Ropero, J.;  Colón Y.; Johnson-Restrepo B., Romañach R. J., Near infrared chemical imaging slope as new method to study tablet compaction and tablet relaxation.  Applied Spectroscopy, 2011, 65(4), 459 – 465.   

A.U. Vanarase, M. Alcalà, J.I. Jerez Rozo, F.J. Muzzio and R.J. Romañach, “Real-time monitoring of drug concentration in a continuous powder mixing process using NIR spectroscopy, Chemical Engineering Science, 2010, 65(21), 5728 – 5733.

Ropero J.; Beach L.; Alcalà M.; Rentas R.; Davé R.N.; Romañach, R.J.  Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding. Part I: Development of the Methodology, Journal of Pharmaceutical Innovation, 2009, 4(4), 18.  

Beach L.; Ropero J.;  Mujumdar A.; Alcalà M.; Romañach R J.; Davé, R.N. Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding Part II: Quantification of Enhanced Flow Properties of Surface Modified Active Pharmaceutical Ingredients. Journal of Pharmaceutical Innovation, 2010, 5(1-2), 1 -13.  

Alcalà M.; Ropero J.; Vázquez R.; Romañach, R.J.  Deconvolution Of Chemical And Physical Information From Intact Tablets NIR Spectra. Two- And Three-Way Multivariate Calibration Strategies For Drug Quantitation, Journal of Pharmaceutical Sciences, 2009, 98(8), 2747 - 2758.

J. Mercado, M. Alcala, K.M. Karry; J.L. Ríos-Steiner, R.J. Romañach, “Design and In-Line Raman Spectroscopic Monitoring of a Protein Batch Crystallization Process”, Journal of Pharmaceutical Innovation, 2008, 3(4), 271 – 279. 

Alcalà M.; León J.; Ropero J.; Blanco M.; Romañach R.J.  Analysis of low content drug tablets by transmission near infrared spectroscopy:  Selection of calibration ranges according to multivariate detection and quantitation limits of PLS models”, Journal of Pharmaceutical Sciences, 2008, 97(12), 5318-5327.

 R.J. Romañach, “PAT – A Team Effort”,  Pharmaceutical Technology Europe, 2008, 20(10), 44 – 46.
 M.T. Carvajal, C. Velázquez, M. Alcalà, and R.J. Romañach, “The Time for Process Understanding”, Pharmaceutical Technology  Europe, 2008, 20(5), 26 - 31. 

R.J. Romañach, “Research initiatives to support science-based pharmaceutical manufacturing”, Pharmaceutical Technology Europe”, 2007, 19(10), 47 – 51. 

M.J. Barajas, A. Rodriguez Cassiani, W. Vargas, C. Conde, J. Ropero, J. Figueroa, and R.J. Romañach, “A Near Infrared Spectroscopic Method for Real Time Monitoring of Pharmaceutical Powders during Voiding”, Applied Spectroscopy, 2007, 61(5), 490 – 496. 

C. Aguirre-Mendez and R. Romañach, “A Raman spectroscopic method to monitor magnesium stearate in blends and tablets”, Pharm. Technol. Asia Pacific, 2007, 1(1), 9–15, and Pharm. Technol. Europe, 19(9), 53-61. 

P.  Hernández, S. Romero-Torres, D. Radspinner, N. Rodríguez-Hornedo, J.J. Dougherty, and R.J. Romañach, The Real Challenge is Moving to a PAT System – IFPAC/INDUNIV PAT Summit, Journal of Process Analytical Technology, 2006, 3(6), 20-23.  

R.J. Romañach, “An Exciting Time for Pharmaceutical Process Research and Improvement”, Conference Proceedings 4to Congreso y Exposición Tecnología Farmacéutica, October 2006, Buenos Aires, Argentina. 

K. Karry, J. Figueroa, R. Rentas, D. Ely , M. Teresa Carvajal, and R.J. Romañach, “Towards a 360º View of Blend Uniformity”, Conference Proceedings 4to Congreso y Exposición Tecnología Farmacéutica, October 2006, Buenos Aires, Argentina. 

R. Parrilla, M. Vega, M. Pabón, and R.J. Romañach, “Innovation Within the PAT Context”,  Journal of Process Analytical Technology. 2006, 3(4), 25-28. 

C. Peroza Meza, M.A. Santos, and R.J. Romañach, “Quantitation of drug content in a low dosage formulation by Transmission Near Infrared Spectroscopy”, 2006, 7(1), Article 29 ( 

R.J. Romañach, “Presenting PAT to Non-PAT Experts”, Journal of Process Analytical Technology, 2006, 3(1), 22 – 25. 

 J. Colón Soto, C. Peroza Meza, W. Caraballo, C. Conde, T. Li, K. R. Morris, and R. J. Romañach, “On Line Non-Destructive Determination of Drug Content in Moving Tablets Using Near Infrared Spectroscopy”, Journal of Process Analytical Technology, 2005, 2(5), 8 -15. 

G. Cook, T. Navedo, P. Pérez, M. Hormaza, R. Cooley, and R.J. Romañach, “PAT from A to Z – News from Induniv Forum for Innovation Meeting”, Journal of Process Analytical Technology, 2005, 2(3), 21 – 23. 

R.J. Romañach, “News from the PRPQA Meeting: Progress in PAT and Pharmaceutical Quality for the 21st Century”, Journal of Process Analytical Technology, 2005, 2(2), 21 – 22. (

A. L. Morales-Cruz, R Tremont, R. Martínez, R. Romañach, and C. R. Cabrera*, “Atomic Force Measurements of 16-mercaptohexadecanoic Acid and its Salt with CH3, OH, and CONHCH3 Functionalized Self-Assembled Monolayers”, Applied Surface Science, 2005, 241(3-4), 371-383.

R.J. Romañach, “Pharmaceutical Analytical Chemistry: Bringing the Pharmaceutical Industry to the Classroom”, Journal of Process Analytical Technology, 2004, 1(2), 19 – 23. (

R.J. Romañach, “Is PAT the Beginning of a Revolution in Pharmaceutical Manufacturing? – A Personal Interpretation of the PAT Initiative”, Journal of Process Analytical Technology, 2004, 1(1), 10 – 12. 

L. Saliceti-Piazza, R. Buxeda, and R. Romañach, “The Industrial Biotechnology Learning Centre (IBLC): an industry-academia training model in response to strategic high-tech economic development”, Proceedings of 7 th Baltic Region Seminar on Engineering Education, St. Petersburg, Russia, September 4 -6, 2003.

R.J. Romañach and M.A. Santos, “Content Uniformity Testing with Near Infrared Spectroscopy”, American Pharmaceutical Review, 2003, 6(2), 62 – 67.

R. Buxeda, L. Saliceti, R. Romañach, C. Ríos Velázquez, J. Gill, J.I. Vélez Arocho, D. Rámirez and A. Ruiz, “The Incorporation of Biotechnology into the Higher Education System to Contribute to a Knowledge-Based Economy”, Dimensión, 2002. 16(2), 13 – 16.

M  Popo, S. Romero-Torres, C. Conde , R.J. and Romañach, “Blend Uniformity Analysis  Using Stream Sampling and Near Infrared Spectroscopy”,  AAPS PharmSciTech 2002; 3 (3) article 24 ( 

 J.L. Ramirez, M.K. Bellamy, and R.J. Romañach, “A novel method for Analyzing Thick Tablets by Near Infrared Spectroscopy”, AAPS PharmSciTech 2001; 2 (3) article 11 (

Publications (while in Industry-The Upjohn Mfg. Co.)

 R.J. Romañach, S.F. Garcia, O. Villanueva, F. Perez, “Combining Efforts for Cleaning Equipment in Active  Pharmaceutical Ingredient (API) Facilities”, Pharmaceutical Technology,  p. 46 – 58, 1999, 23(1), 46.  

R.J. Romañach, "Vacancy Detection Ion Chromatography", Revista Colegio de Quimicos de Puerto Rico, 1989. 

J.G. Shabushnig, C.S. Foran, and R.J. Romañach, "A Comparison of Machine Vision Ssytems for Label Code Inspection", Pharmaceutical Technology, 1989, 13(9), 114. 

Graduate School Research (Ph.D. University of Georgia): 

R.J. Romañach and J.A. de Haseth, "Flow Cell CCC/FT-IR Spectrometry", J. of Liquid Chromatography, 1988, 11(1), 133.

R.J. Romañach and J.A. de Haseth, "Comparison of Columns for the Analytical High Speed Countercurrent Chromatograph", J. of Liquid Chromatography, 1988, 11(1), 91.

R.J. Romañach and J.A. de Haseth, "High Speed Countercurrent Chromatography/Fourier Transform Infrared (HSCCC/FT-IR) Spectrometry" in 1985 International Conference on Fourier and Computerized Infrared Spectroscopy  J. Grasselli, Ed., SPIE, 1985, 553, 349.

R.J. Romañach, Y. Ito and James A. de Haseth, "Preliminary Studies for Interfacing Countercurrent Chromatography (CCC) with Fourier Transform Infrared (FT-IR) Spectrometry", J. Liquid Chromatography., 1985, 8(12), 2209.

Undergraduate Research:

C.J. O'Connor, R.J. Romañach, D.N. Robertson, E.E. Edouk and F.R. Fronczek, "Synthesis, Molecular Structure, Magnetic Properties of Some Copper (II) Complexes of Bis (2-pyridylmethyl) Ketazine", Inorganic Chemistry, 1983, 22, 449.