MORPHY RICHARDS IRON FILTERS - AIR COMPRESSOR WATER FILTER - BUY FILTER QUEEN.
Lead Generation Approaches in Drug Discovery
An integrated overview of modern approaches to lead discovery87% (5)
Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including:
The evolution of the lead discovery process, key concepts, current challenges, and future directions
Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process
Knowledge-based in silico or "virtual" screening
Theory and practice of the fragment-based approach to lead discovery
The opportunities and challenges presented by multi-target drug discovery (MTDD)
De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules
The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space
Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery
The utility of parallel synthesis and purification in lead discovery
With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Morphy Richards CA75 Senior dry iron.
For more than two decades this was the top selling iron in the UK. Available in a chrome or coloured case , over thirty million were made at the Morphy Richards St. Mary Cray factory on the outskirts of London. Although electric irons had been around for many years the model stood out for its adjustable temperature settings and green light that went out when it was hot enough , also the robust construction and American styling. Made from 1936 ( with a ceramic shell later made in metal ) with a two year guarantee , every part was available for repairs and the manufacturer supplied a " thermocouple" test jig to adjust a replacement thermostat if one needed replacing as the bi metal strip that did the work inside it would eventually start sticking and alter the temperature setting. A forty year production run shows that the models popularity hardly faltered.Morphy Richards toaster model TU1D.
The electric toaster was an invention of the Compton Electric company in the UK. Morphy Richards brought out this iconic model in 1948 using the same bi metal thermostatic technology used in their irons.The manufacturer supplied any spare part that was needed including the internal heating elements which would blow if the customer went on a fork poking expedition. It was in production for over twenty years and manufacturers still copy its retro American shape.
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