Context

Taking a thorough family health history is a first step in evaluating a patient's genetic predisposition for developing cancer. As you'll learn in this lesson, there are certain "genetic red flags" that indicate whether a person is at higher risk for developing cancer than other members of the population.
Information such as the number of relatives who've had a particular type of cancer, age of onset of the disease, and severity (e.g., multiple tumors) can help you determine whether a patient's at particularly high risk.

Drawing a pedigree is a useful way to spot these red flags. As you may remember, pedigrees use standard symbols to represent family history information. Pedigrees also allow you to visualize inheritance patterns,for example, whether a gene mutation is dominant, recessive, autosomal, or X-linked. You can review these symbols and how to draw a pedigree in the Videos & tutorials section of this lesson.

Your assessment of risk will lead you to clinical practice decisions. You'll learn more about this in Lesson 4.

Human chromosomes in a breast cancer cell

Photo credits

Wellcome images:
DNA people by Daniel Salaman
Human chromosomes in breast cancer cell by Paul J. Smith & Rachel Errington


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