Discovering design principles of biological systems and improving human health

A central challenge in biology is to understand how complex biological networks regulate precise cellular behaviors and how disregulation leads to disease. We investigate mechanisms of how collective cellular decision making gives rise to reliable tissue organization, and we develop novel drug discovery approaches for reverting disease states. Our multidisciplinary team uses cutting-edge techniques from quantitative imaging, single-cell technologies, machine learning and mathematical modeling to tackle challenging questions in systems biology and systems pharmacology.

Neutrophil signaling network