Welcome to the Fisetin Project Tracking Workspace

This project is an attempt to find whether fisetin, a naturally-occurring flavonoid, can be of benefit in Amyotrophic Lateral Sclerosis.

Note that this is NOT intended to be a treatment or cure for any condition. This is merely a project for ALS patients who wish to participate in a DIY project. Since fisetin is not a patentable treatment, there is no institutional interest in performing real clinical trials.

Project protocol can be found on the Project Documents page.

Brief Description Of Fisetin:

Fisetin is a member of the flavonol subclass of flavonoids. Related members of the subclass include kaempferol, myricetin and quercetin. Fisetin is found in fruits, including strawberries, persimmons, kiwi fruit, peaches, grapes, apples and tomatoes, and in vegetables, including onions and cucumbers. Fisetin was a little known flavonoid until October 2006, when scientists from the Salk Institute reported that fisetin was found to boost memory in mice by stimulating the signaling pathways that enhance long-term memory and also play an important role in memory formation. Since cognitive deficits are common in those 60 years and older, this finding was looked upon as being a very significant one. Aged rats fed a diet enriched in strawberry extract for two months did much better in a test that measured cognitive performance than rats fed a control diet. Strawberries appear to be the highest natural source of fisetin. Unfortunately one would need to consume many pounds of strawberries to get a pharmaceutical level of fisetin. This would have obvious disadvantages.