Msk
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Rheumatology

Spectrum: Inflammatory arthritis | Crystal arthritis | Connective tissue disease | Vasculitis | Fibromyalgia, PMR | Pain syndromes

Rheumatoid Arthritis: DMARD: ASAP: best response(/cure?): biologics (eg AntiTNF) + Methotrexate (eg 20wkly)

Hi ESR: DD: Infection | Myeloma | Connective tissue disease

Cytokine modulators [BNF]: TNF inhibitors: Adalimumab=Humira(R) | Etanercept=Enbrel(R) | Infliximab=Remicade(R) | Rituximab | Anakinra=Kineret(R) | Abatacept=Orencia(R)

Osteomalacia

 

Osteoporosis

Clinical

Nee: hypopit, eyesight/sensory defic, anticonvulsants

Rsp: GC, restrict lung dis<-spin Th fract; mort: pneumonia etc

Crc: aortic calcification->icr BMD

Dig: malabsorption (Ca, VitD), bisphosph SE, CLD/Alcoholism; obes protects

Ugo: CKD (HPTH, osteopor); POF; hypogonadism

Msk: exerc/immobil, prev fract; ONJ<-BP; Ix: DXA, turnover markers

Ski: sunlight

Psy: dementia

Hae: Hb'opathies, RA; coel

Emn: GH, fT4, PTH, GC, E2; dairy, green leaves; lo wt vs obes

Tum: malignancy; chemo/XRT (:POF)

Xtn: smoking, GC, Arimidex, Zoladex; Rx: Ca/VitD, HRT, SERMS, BP, PTH, Strontium

Fam: FHx; age; Caucasian

Ix: DEXA, bone turnover, screen 2ry causes

Clin Med (CME)

Systemic VasculitisPostmenopausal OsteoporosisSjögren's Syndrome, B cell depletion in SLE, Crystal Arthritis,