American Airlines Flight 587, an Airbus A300, crashed into the Belle Harbor neighborhood of Queens, a borough of New York City, New York, shortly after takeoff from John F. Kennedy International Airport on November 12, 2001. This is the second deadliest U.S. aviation accident to date, after American Airlines Flight 191.
With 260 fatalities on board and 5 on the ground, this accident has the third highest death toll of any accident involving an Airbus A300. Iran Air Flight 655 and China Airlines Flight 140 had higher fatalities.
The accident took place two months after the September 11 attacks on the World Trade Center in Manhattan. Several factors, such as the date, aircraft size, airline, eyewitness accounts, and location in New York, raised concerns that the crash was caused by another terrorist attack Al-Qaeda listed the crash among its successes, and a Canadian militant cooperating with authorities suggested that it had been brought down with a shoe bomb. Nonetheless, terrorism was officially ruled out as the cause by the National Transportation Safety Board, which instead attributed the disaster to the first officer's overuse of rudder controls in response to wake turbulence.
Original Source: http://en.wikipedia.org/wiki/American_Airlines_Flight_587