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Education Research Experience Teaching Experience Publications Presentations Awards and Honors

Education
Duke University, Durham, NC                                                                                   2010-2014
  • Ph.D. Molecular Genetics and Microbiology
  • Advisor: Bryan R. Cullen, Ph.D.
  • Dissertation: Interactions of Mammalian Retroviruses with Cellular MicroRNA Biogenesis and Effector Pathways
  • Certificate in College Teaching
  • Robert M. Bass Instructional fellow 2014
  • Preparing Future Faculty fellow 2013
North Carolina State University, Raleigh, NC                                                         2006-2010
  • BS degrees in Zoology and Biochemistry
  • BA in Chemistry
  • summa cum laude (GPA 3.89)
  • Phi Beta Kappa
  • University Scholars Program
  • Biochemistry Honors Program
  • College of Agricultural and Life Sciences Honors Program
North Carolina School of Science and Mathematics, Durham, NC                    Class of 2006

Research Experience
Julius Maximilians University Würzburg, Würzburg, Germany        2015-Present
Postdoctoral Fellow with Prof. Dr. Lars Dölken
  • Demonstrated non-canonical translation initiation in herpes simplex virus 1 (HSV-1) infection
  • Developed methodologies for mapping RNA binding sites of viral proteins involved in shutoff of host gene expression
  • Determined the global phosphorylation patterns of the C-terminal domain of RNA Polymerase II during infection with HSV-1
Duke University, Durham, NC
Graduate Student with Bryan R. Cullen, Ph.D.                                                         2011-2014
  • Determined the extent of molecular interactions between human immunodeficiency virus type 1 RNAs and cellular RNA interference effectors
  • Developed high throughput sequencing systems to screen for CRISPR/Cas9-mediated genomic mutagenesis
  • Examined Dicer knockout human cell lines for engineered microRNA targeting
  • Discovered noncanonical biogenesis of miRNAs from bovine foamy virus
  • Identified regulatory mechanisms of herpes simplex virus 1 latency-associated proteins

North Carolina State University, Raleigh, NC
Undergraduate Student with HC Sunny Liu, Ph.D.                                                  2007-2010

  • Identified several immune-related cellular mRNA targets for chicken miRNAs 10a and 57
  • Performed screens to identify host protein interactions with Marek’s disease virus protein UL49.5

Undergraduate Student with Bruce Novak, Ph.D.                                                   2007

  • Synthesized antimicrobial peptides linked to polymer backbones for use as a sterilizing bandage

Undergraduate Student with Coby Schal, Ph.D.                                                      2006

  • Characterized non-reproductive mating habits of German cockroaches during conditions of protein starvation


Teaching Experience
Julius Maximilians University Würzburg, Würzburg, Germany                           2016-Present

  • Laboratory mentor for two bachelor theses
  • Laboratory instructor for 06077800 Virology I (for Bachelor Stundents) and BioEU
    Master students, Fall 2016-Present
Durham Technical Community College, Durham, NC                                           2013-2015
  • Lecture and laboratory instructor for BIO 111 General Biology I, 2014-2015
  • Laboratory instructor for BIO 275 Microbiology, 2014-2015
  • Guest lecturer for BIO 275 Microbiology and BIO 280 Biotechnology, Fall 2013-Spring 2014

Duke University, Durham, NC                                                                                    2012-2014

  • Certificate in College Teaching
  • Preparing Future Faculty fellow
  • Laboratory instructor for BIO 201 Gateway to Biology:  Molecular Biology, Spring 2014
  • Teaching assistant for BCH 301 Introduction to Biochemistry I, Summer 2012

North Carolina State University, Raleigh, NC                                                         2007-2010

  • Drop-in and scheduled tutor with the Undergraduate Tutorial Center for zoology, chemistry, and biochemistry courses

  • Laboratory instructor for CSC 200 Introduction to Computers and Their Uses, Fall 2007
  • Tutor of the Year Nominee in 2007


Publications
Hennig T, Michalski M, Rutkowski AJ, Djakovic L, Whisnant AW, Friedl MS, Jha BA, Baptista MAP, L’Hernault A, Erhard F, Dölken L, Friedel CC. 2018. HSV-1-induced disruption of transcription termination represents a cellular stress response and increases chromatin accessibility downstream of genes. PLoS Pathog 14(3): e1006954.

Bogerd HP, Kennedy EM, Whisnant AW, Cullen BR. 2017. Induced Packaging of Cellular MicroRNAs into HIV-1 Virions Can Inhibit Infectivity. mBio 8(1) e02125-16.

Kennedy EM, Whisnant AW, Kornepati AV, Marshall JB, Bogerd HP, Cullen BR. 2015. Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer. Proc Natl Acad Sci U S A. Dec 15;112(50):E6945-54.

Kennedy EM, Kornepati AVR, Goldstein M, Bogerd HP, Poling BC, Whisnant AW, Kastan MB, Cullen BR. 2014. Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells using a bacterial CRISPR/Cas RNA-guided endonuclease.  J Virol 88(20):11965-72.

Bogerd HP, Skalsky RL, Kennedy EM, Furuse Y, Whisnant AW, Flores O, Schultz KL, Putnam N, Barrows NJ, Sherry B, Scholle F, Garcia-Blanco MA, Griffin DE, Cullen BR. 2014. Replication of Many Human Viruses Is Refractory to Inhibition by Endogenous Cellular MicroRNAs. J Virol 88(14):8065-76.

Bogerd HP, Whisnant AW, Kennedy EM, Flores O, Cullen BR.  2014. Derivation and characterization of Dicer- and microRNA-deficient human cells.  RNA 20(6):923-37.

Whisnant AW, Kehl T, Bao Q, Materniak M, Kuzmak J, Löchelt M, Cullen BR.  2014.  Identification of novel, highly expressed retroviral microRNAs in cells infected by bovine foamy virus.  J Virol 88(9):4679-86. Spotlight Article

Whisnant AW, Bogerd HP, Flores O, Ho P, Powers JG, Sharova N, Stevenson M, Chen CH, Cullen BR. 2013.  In-Depth Analysis of the Interaction of HIV-1 with Cellular microRNA Biogenesis and Effector Mechanisms.  MBio 4(2).  E00193-13.

Flores O*, Nakayama S*, Whisnant AW, Javanbakht H, Cullen BR, Bloom DC.  2013.  Mutational Inactivation of Herpes Simplex Virus 1 MicroRNAs Identifies Viral mRNA Targets and Reveals Phenotypic Effects in Culture. J Virol 87(12):6589-603. *Authors contributed equally to this work.


Oral Presentations
43rd Annual International Herpesvirus Workshop                                                2018
Vancouver, Canada
Comprehensive Reannotation of the Herpesviral Transcriptome and Translatome

Power of Viruses                                                                                                        2018
Poreč, Croatia
Comprehensive Reannotation of the Herpesviral Transcriptome and Translatome

28th Annual Meeting of the Society for Virology 2018                                        2018
Würzburg, Germany
Comprehensive Reannotation of the Herpesviral Transcriptome and Translatome

Die Lange Nacht der Ideen                                                                                       2017
Berlin, Germany
A World in a Grain of Sand: How Herpes Hijacks Your Cells

Poster Presentations
13th EMBL Conference: Transcription and Chromatin                                         2018
Heidelberg, Germany
RNA-Mediated Shutoff of Host Gene Expression Induced by Herpes Simplex Virus Type 1

43rd Annual International Herpesvirus Workshop                                                2018
Vancouver, Canada
Comprehensive Reannotation of the Herpesviral Transcriptome and Translatome

EMBO Regulation of RNA 3' end formation across eukaryotic genomes         2017
Oxford, United Kingdom
RNA-Mediated Shutoff of Host Gene Expression Induced by Herpes Simplex Virus Type 1

42nd Annual International Herpesvirus Workshop                                                2017
Ghent, Belgium
RNA-Mediated Shutoff of Host Gene Expression Induced by Herpes Simplex Virus Type 1

27th Annual Meeting of the Society for Virology                                                   2017
Marburg, Germany
Examining Herpes Simplex Virus Type 1-Induced Host Shutoff at the Transcriptional Level

26th Annual Meeting of the Society for Virology                                                   2016
Münster, Germany
Novel, highly expressed retroviral microRNAs in cells infected by bovine foamy virus

Network Meeting of the Alexander von Humboldt Foundation                          2016
Düsseldorf, Germany
Effects on RNA Metabolism During Herpesviral Infection

Symposium on RNA Biology X                                                                        2013
Chapel Hill, NC
Analysis of miRNA expression by bovine foamy virus

25th Workshop on Retroviral Pathogenesis                                                    2013
Reykjavik, Iceland
Analysis of miRNA expression by bovine foamy virus

8th Duke Center for AIDS Research Annual Fall Scientific Retreat                2012
Durham, NC
MicroRNA interactions during HIV-1 infection

98th Poultry Science Association Annual Meeting                                          2009
Raleigh, NC
Identification of potential target genes of the novel chicken-specific miRNA, miR-NC-57

8th NC State University Undergraduate Summer Research Symposium       2009
Raleigh, NC
Identification of target genes for microRNA miR-10a
Identification of potential target genes of the novel chicken-specific miRNA, miR-NC-57

6th NC State University Undergraduate Summer Research Symposium       2007
Raleigh, NC

Interaction identification of host proteins and Marek's disease virus UL49.5 protein


Awards and Honors 
Merit-based registration award for the International Herpesvirus Worksop    2018

Discussion panelist at 68th Lindau Nobel Laureate Meeting                             2018

Alexander von Humboldt Foundation Postdoctoral Fellow      2015-2017

Best Poster Presentation, MGM Departmental Retreat                                 2014

Robert M. Bass Instructional Fellowship                                                        2014

Duke Center for Virology Travel Award                                                          2013

Viral Oncology Training Grant (T32-CA009111)                                             2011

NCSU Tutor of the Year nominee                                                                   2007

Eagle Scout Rank                                                                                           2006