Appendix 34. ABO & Personality

ABO Polymorphism & Personality

The idea that the ABO blood type is partially involved in the determination of personality is still quite common. This belief is especially popular in Japan and Taiwan. A series of books written by Masahiko Nomi seem to have contributed, to some degree, to the popularity of this theory. The books depicted numerous anecdotal examples, but the statistical analyses were based on subjective data rather than objective one.

Because of this lack of objectivity, I do not think that any association between ABO polymorphism and personality has been really demonstrated. All the claims currently made on this regard seem to be groundless. Or at least they do not seem to withstand scientific evaluation.

ABH antigens are expressed in the primary sensory neurons of the posterior root ganglia in the nervous system. Although there is no direct connection between the sensory neurons and personality, it is still possible that the ABO polymorphism may affect the response of those cells. Apart from neurons, the polymorphic expression of the ABH antigens on other types of cells, including RBCs in circulation, some cells in the digestive tract, some cells in respiratory, endocrine, urinary, and genital organs may indirectly affect the personality.

ABO gene is one of 25,000-plus genes contained in the human genome. But because of the abundance and wide distribution of ABH antigens, I will not be so surprised if in the future, the currently fashionable genome-wide association studies (GWAS) find an association between certain definable personality traits and ABO SNPs.

01 ABO Blood Type


Histo-blood group ABO system, blood group ABO system, ABO system, AB0 system, ABO blood groups, AB0 blood groups, ABO blood types, AB0 blood types, ABO genetic locus, ABO genes, ABO, AB0, A glycosyltransferases, B glycosyltransferases, glycosyltransferases, A transferase, B transferase, cell surface antigens, carbohydrate antigens, oligosaccharide antigens, oligosaccharides, complex carbohydrate antigens, complex carbohydrates, A antigen, B antigen, H antigen, red blood cell antigens, A/B antigens, ABH antigens, glycolipid, glycosphingolipids, glycoproteins, oligo sugars, red blood cells, RBC, blood transfusion, transfusion medicine, cell/tissue/organ transplantation, transplantation medicine, immunohematology, immunohaematology, immuno-hematology, immunology, ABO genotyping, forensic sciences, legal medicine, human genetics, population genetics, evolution, enzymology, glycobiology, glycosciences, human genes, primate genes, mouse gene, pig genes, alpha 1,3-Gal(NAc) transferases, a1,3-galactosyl transferase, a1,3-GalNAc transferase, structural basis, molecular genetic basis of ABO, ABO polymorphism, single nucleotide polymorphism, SNP, A, B, AB, O, A2, A3, Ax, B3, alleles, weak subgroups, homo sapiens, pig AO genes, cis-AB, B(A), mouse cis-AB gene, ABO genotype, ABO phenotype, DNA methylation, transcription, alternative splicing, Golgi apparatus, transferase chimeras, GBGT1, GGTA1, A3GALT2, monoclonal antibody, sera, plant lectins, Fumi-ichiro Yamamoto, Fumiichiro Yamamoto, F. Yamamoto, Landsteiner, enzyme, kinetics, sugar specificity, acceptor substrate specificity, acceptors, donors, sugars, nucleotide-sugars, genetic engineering, differential susceptibility to infectious diseases, differential cancer susceptibility, alterations in glycosylation in cancer, pancreatic cancer, diets, Peter D'Adamo, Blood type diets, neurobiology, Masahiko Nomi, personality, Burnham Institute, Burnham Institute for Medical Research, Biomembrane Institute, IMPPC, IMPPC Institute of Predictive and Personalized Medicine of Cancer, Institut de Medicina Predictiva i Personalitzada del Càncer,  AABB, ISBT, dbRBC - Blood Group Antigen Gene Mutation Database