47. Glycosyltransferase Gene Family


 

The biosynthesis of A and B antigens are catalyzed by A and B transferases, respectively. However, the common acceptor substrate of the H antigen is also produced by the reaction catalyzed by another glycosyltransferase, α1-2 fucosyltransferase. Oligosaccharide structures are generally synthesized through a series of reactions catalyzed by several glycosyltransferases, rather than a single reaction. It is, therefore, necessary to study the expression of several, if not many, glycosyltransferases in order to understand the expression of certain oligosaccharide antigens. For this purpose, we developed an experimental system to study the expression of 68 human glycosyltransferase genes (Yamamoto et al, 2003). In humans α1-3 Gal(NAc) transferase genes other than ABO genes are non-functional or have become pseudogenes during evolution. Therefore, only one gene, which is indicated by an arrow, represents this family. As you see, there are many genes encoding glycosyltransferases. They were categorized depending on which sugar is transferred. It should be noted that this table does not cover all the glycosyltransferases, though the majority of the enzymes are included.

48. Glycosyltransferase Gene Expression in Human Tissues

01. ABO Blood Group System

Yamamoto, M., Yamamoto, F., Luong, T.T., Williams, T., Kominato, Y., Yamamoto, F. (2003). Expression profiling of 68 glycosyltransferase genes in 27 different human tissues by the systematic multiplex reverse transcription-polymerase chain reaction method revealed clustering of sexually related tissues in hierarchical clustering algorithm analysis. Electrophoresis 24, 2295-2307. 


Keywords

Histo-blood group ABO system, blood group ABO system, ABO system, AB0 system, ABO blood groups, AB0 blood groups, ABO blood types, AB0 blood types, ABO genetic locus, ABO genes, ABO, AB0, A glycosyltransferases, B glycosyltransferases, glycosyltransferases, A transferase, B transferase, cell surface antigens, carbohydrate antigens, oligosaccharide antigens, oligosaccharides, complex carbohydrate antigens, complex carbohydrates, A antigen, B antigen, H antigen, red blood cell antigens, A/B antigens, ABH antigens, glycolipid, glycosphingolipids, glycoproteins, oligo sugars, red blood cells, RBC, blood transfusion, transfusion medicine, cell/tissue/organ transplantation, transplantation medicine, immunohematology, immunohaematology, immuno-hematology, immunology, ABO genotyping, forensic sciences, legal medicine, human genetics, population genetics, evolution, enzymology, glycobiology, glycosciences, human genes, primate genes, mouse gene, pig genes, alpha 1,3-Gal(NAc) transferases, a1,3-galactosyl transferase, a1,3-GalNAc transferase, structural basis, molecular genetic basis of ABO, ABO polymorphism, single nucleotide polymorphism, SNP, A, B, AB, O, A2, A3, Ax, B3, alleles, weak subgroups, homo sapiens, pig AO genes, cis-AB, B(A), mouse cis-AB gene, ABO genotype, ABO phenotype, DNA methylation, transcription, alternative splicing, Golgi apparatus, transferase chimeras, GBGT1, GGTA1, A3GALT2, monoclonal antibody, sera, plant lectins, Fumi-ichiro Yamamoto, Fumiichiro Yamamoto, F. Yamamoto, Landsteiner, enzyme, kinetics, sugar specificity, acceptor substrate specificity, acceptors, donors, sugars, nucleotide-sugars, genetic engineering, differential susceptibility to infectious diseases, differential cancer susceptibility, alterations in glycosylation in cancer, pancreatic cancer, diets, Peter D'Adamo, Blood type diets, neurobiology, Masahiko Nomi, personality, Burnham Institute, Burnham Institute for Medical Research, Biomembrane Institute, IMPPC, IMPPC Institute of Predictive and Personalized Medicine of Cancer, Institut de Medicina Predictiva i Personalitzada del Càncer,  AABB, ISBT, dbRBC - Blood Group Antigen Gene Mutation Database

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