appendix-31-abo-diet-1

Appendix 31. ABO & Diet


ABO Polymorphism & Diet

Within the gene, at the nucleotide sequence level, the differences among individuals with different human ABO alleles are minimal with only minor substitutions and deletions/insertions. These differences result in changes in the gene-encoded proteins: A and B glycosyltransferases and non-functional O proteins. The specificity and activity of the glycosyltransferases encoded by weak and rare A and B subgroup alleles, as well as cis-AB and B(A) alleles that specify the expression of both A and B antigens by single genes, are modified. The functional enzymes, A and B transferases, are involved in the biosynthesis of the oligosaccharide A and B antigens, respectively.

Because these antigens are expressed on the epithelial cells of gastrointestinal tract, in addition to red blood cells (RBCs), it is theoretically possible that these antigens may interact with carbohydrate-recognizing proteins like lectins present in the diet. Because A and B antigens are carried on glycoproteins and glycolipids on the cell surface, they may also modify the functions of those glycoconjugates.

ABH antigens are not restricted to the humans, but they are also present in nature. Therefore, it is possible that A/B antigens in the diet may also interact, within the human body, with naturally occurring antibodies against those antigens and/or with lymphocytes that carry those antibodies, in addition to the carbohydrate-binding proteins. 

Appendix 32. ABO Blood Type Diets

Molecular genetic basis of the blood group ABO system


Keywords

Histo-blood group ABO system, blood group ABO system, ABO system, AB0 system, ABO blood groups, AB0 blood groups, ABO blood types, AB0 blood types, ABO genetic locus, ABO genes, ABO, AB0, A glycosyltransferases, B glycosyltransferases, glycosyltransferases, A transferase, B transferase, cell surface antigens, carbohydrate antigens, oligosaccharide antigens, oligosaccharides, complex carbohydrate antigens, complex carbohydrates, A antigen, B antigen, H antigen, red blood cell antigens, A/B antigens, ABH antigens, glycolipid, glycosphingolipids, glycoproteins, oligo sugars, red blood cells, RBC, blood transfusion, transfusion medicine, cell/tissue/organ transplantation, transplantation medicine, immunohematology, immunohaematology, immuno-hematology, immunology, ABO genotyping, forensic sciences, legal medicine, human genetics, population genetics, evolution, enzymology, glycobiology, glycosciences, human genes, primate genes, mouse gene, pig genes, alpha 1,3-Gal(NAc) transferases, a1,3-galactosyl transferase, a1,3-GalNAc transferase, structural basis, molecular genetic basis of ABO, ABO polymorphism, single nucleotide polymorphism, SNP, A, B, AB, O, A2, A3, Ax, B3, alleles, weak subgroups, homo sapiens, pig AO genes, cis-AB, B(A), mouse cis-AB gene, ABO genotype, ABO phenotype, DNA methylation, transcription, alternative splicing, Golgi apparatus, transferase chimeras, GBGT1, GGTA1, A3GALT2, monoclonal antibody, sera, plant lectins, Fumi-ichiro Yamamoto, Fumiichiro Yamamoto, F. Yamamoto, Landsteiner, enzyme, kinetics, sugar specificity, acceptor substrate specificity, acceptors, donors, sugars, nucleotide-sugars, genetic engineering, differential susceptibility to infectious diseases, differential cancer susceptibility, alterations in glycosylation in cancer, pancreatic cancer, diets, Peter D'Adamo, Blood type diets, neurobiology, Masahiko Nomi, personality, Burnham Institute, Burnham Institute for Medical Research, Biomembrane Institute, IMPPC, IMPPC Institute of Predictive and Personalized Medicine of Cancer, Institut de Medicina Predictiva i Personalitzada del Càncer,  AABB, ISBT, dbRBC - Blood Group Antigen Gene Mutation Database

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