Our research interests are mainly focused on structural analysis of specimens of biological relevance by means of electron tomography and image processing. We are exploring the structural alterations in the sub-cellular architecture under normal and pathological conditions in neurodegenerative diseases. We are also interested in structural elucidation of the microtubule organizing centre (MTOC), an important and complex cellular organelle in eukaryotes, in close collaboration with Dr. Sam Li (UCSF). We also collaborate with cellular and molecular biology groups in other experimental structural studies. An important pillar of our research is the development and application of computational methods and tools for electron tomography.