The University of Louisville has the pleasure of organizing and hosting the 2015 Midwest Membrane Trafficking and Signaling Symposium, sponsored by the American Society for Cell Biology (ASCB). This one-day meeting, which will take place in the Kosair Charities Clinical and Translational Research Building at the University of Louisville on Friday, the 24th of July, provides opportunities to bring together scientists whose research is focused on membrane trafficking and signaling in the context of both health and disease.