I first established my group at the Cambridge Institute for Medical Research in 2006 funded by a MRC Career development award. In 2012 the lab moved to the School of Bioscience at the University of Sheffield where it is based in the Florey building. In the school we have an excellent concentration of cell biology groups who share similar interests in intracellular trafficking (Maib, Smythe, King, Erdmann, Humphries and Seward). We are also very lucky to have access to range of excellent facilities including high content screening, proteomics and advanced imaging.
My group is interested in dissecting the molecular process that underpin constitutive secretion and post-Golgi trafficking. Constitutive secretion is a conserved process required for the delivery of newly synthesised proteins and lipids to plasma membrane as well as the exocytocis of extracellular factors such as cytokines, lipoproteins and antibodies. To study these processes we use a wide variety of systems and techniques such as proteogenomics, functional genomics and advanced imaging. Where possible we try to follow the science which has meant we are always open to collaborating with other groups who have the most suitable expertise.
Congratulations to Sam for successfully defending his PhD thesis (Feb 2025). Thank you to the examiners Luke Chamberlain and Dan Humphries.
Congratulations to Polly for successfully defending her PhD thesis (Jan 2025). Thank you to the examiners Evan Reid and Liz Smythe.
Nice to see our work being recognised by the NC3R's (2024).
Congratulations to Dan, his NL3P3 paper is accepted for publication in eLife (2024).
Welcome to Amy and Huyen, masters students, who have joined the lab (2024).
Welcome to Amy Page who is doing an integrated masters in the lab.
Congratulations to Ji-Kuan who has got a job at a biotech comany in Taiwan .
Congratulations to Amber Shun-Shion who has got a postdoc postion at AZ.
Congratulations to Ola who has got a postodc postion in Anne Simonson's group in Norway.
Welcome to Amber who has joined the lab for her PhD - October 2023.
Congratulations to Dan his serological paper accepted for publication in iScience (2023).
Ola has passed her PhD viva (19/05/23)! Thanks to David Stephens and Liz Smythe for being excellent examiners.
Congratulations on Ola for submitting her thesis (31/03/23).
Welcome to Linshu who joined the lab for her PhD project in January 2023.
We are excited to see some of our plasma cell work published in PNAS with our long term collaborator Marion Espeli.
Congratulations Jess for passing your PhD viva (27/09/22).
Congratulations to Jess who has just submitted her thesis (27/05/22).
Congratulations to Amber for successfully defending your PhD thesis today (no corrections)!
This week Andrew gave a talk to the WHO working group on COVID-19 assays group.
Congratulations to Dan, Ola and Amber for their recent paper on medRxiv.
Congratulations to Ola who has just published her first middle author paper.
Congratulations to Amber who has just submitted her thesis!
Our collaboration with the Luzio lab has just come out in JCS. Luther was a former project student in the lab.
Congratulations Wirda on successfully defending your PhD online! A big thank you to Jason King and Luke Chamberlain for being fantastic examiners.
This week Andrew discussed some of the lab's CoV-2 work at the Faculty of Science seminar program.
Our methods chapter has just been published in Exocytosis and Endocytosis methods and protocols.
Testing CRISPR/Cas9 knock out pools from Synthego. These pools were generated for the Science paper. Very impressed by the efficiency of the knock outs!
Ola has been implementing lentiviral CRISPR/Cas9 screening in the group. Results look very promising. Thanks to the Lehner lab for the plasmids and advice.
Sam and Polly have just joined as new PhD students for the lab.
Our collaboration with Krogen lab has just been published in Science.