Indications for Emergency Treatment

• Confusion, agitation, coma, or seizures secondary to low serum sodium levels

Goal Na+

• Symptoms of severe hyponatremia

o Goal of 5 – 6 mEq/L increase in serum sodium in first 1 – 2 hours

o Goal of 120 mEq/L initially followed by slower correction to approximately 130 mEq/L over the following 24-48 hours

o Initial goal serum sodium level should be lower if the baseline serum sodium is < 100 mEq/L

3% NaCl = 1027 mOsml/L

7.5% NaCl = 2,567 mOsm/L

8.4% Sodium Bicarbonate = 2000 mOsm/L

23.4% NaCl = 8011 mOsm/L

1. Sodium chloride. Micromedex [Electronic version].Greenwood Village, CO: Truven Health Analytics. Retrieved December 21, 2019, from http://www.micromedexsolutions.com/

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