Mass spectrometry has become one of the most important tools for the study of molecules of all sizes. Using mass spectrometry to study protein-ligand interactions provides detailed molecular information about binding interactions, stoichiometry and binding locations of ligands to proteins of interest.
Many medicinal compounds bind as ligands to proteins or enzymes in human cells to elicit their biological effects. Examining the possible interactions between proteins and ligands can help us understand how small molecules can cause biological changes in cells.