Patrick Rüther (UCPH)

About Patrick

With degrees in `Molecular Biotechnology`, I acquired a broad background in protein biochemistry, cell biology, and organic chemistry. As a student trainee at a pharmaceutical company, I had the opportunity to get hands-on experience in applied research, which set the foundation for my interest in the scientific fields of proteomics and analytical technology. My subsequent Bachelor’s thesis dealt with drug target profiling using chemical proteomics. During my Master’s studies, I spent nine months in the United States, where I did research in proteomics on breast cancer cells at Oklahoma State University and drug product characterization at Genentech. For my Master’s thesis, I went back to chemical proteomics, where I developed and tested an enrichment-tool for proteins involved in epigenetics. In the same research group, I subsequently supported the technology-focused ProteomeTools project, aiming at the optimization of targeted proteomics and providing reference data to improve database searching.

My PhD project aims at the optimization of the technology, used for data-acquisition in palaeoproteomics. Compared to samples produced under laboratory conditions, ancient and degraded proteins bring about new challenges to mass-spectrometry. To overcome these, I will apply and refine existing strategies, such as top-down proteomics and different modes of peptide fragmentation, and benchmark them with modern and artificially aged reference proteins. By providing methods with superior sensitivity and access to a wider range of age-related modifications, I hope to contribute to the field of cultural heritage material analysis.

CV

Academic

2014-2017 Master of Science in Molecular Biotechnology, Technical University of Munich

2015 Exchange semester, Faculty of Biochemistry, Oklahoma State University

2011-2014: Bachelor of Science in Molecular Biotechnology, Technical University of Munich

Professional Career

2017 Research assistant, Chair of Proteomics and Bioanalytics, Technical University of Munich

2016 Internship, Dept. Protein Analytical Chemistry, Genentech Inc. San Francisco

2012-2014 Cooperative Studies, Various Depts., Roche Diagnostics GmbH Penzberg

2011 Internship, Dept. Molecular Biology, Institute Dr. Erdmann Rheda

Publications

Mackie, M. , Rüther, P. , Samodova, D. , Di Gianvincenzo, F. , Granzotto, C. , Lyon, D. , Peggie, D. ., Howard, H. , Harrison, L. , Jensen, L. ., Olsen, J. . and Cappellini, E. (2018), Palaeoproteomic Profiling of Conservation Layers on a 14th Century Italian Wall Painting. Angew. Chem. Int. Ed.. Accepted Author Manuscript. . doi:10.1002/anie.201713020

Contacts

E-mail patrick.ruether@palaeome.org

ORCiD ID https://orcid.org/0000-0003-4461-9828

At: University of Copenhagen

Supervisor: Jesper V. Olsen