トップジャーナルクラブ

トップジャーナルから世界最先端の知見を読み込み発表することで、サイエンスの眼（芽）を育み、医療現場で役立つ情報収集能力や英語力、プレゼンテーションスキルの向上を目指しています！

2025年度

• 2025_1121（担当：大久保）Argiro et al., Gastruloids are competent to specify both cardiac and skeletal muscle lineages. Nat Commun 15: 10172, 2024.

• 2025_1114（担当：石黒）Hakim et al., Macrophages protect against sensory axon loss in peripheral neuropathy. Nature 640 (8057): 212–220, 2025.

• 2025_1114（担当：佐藤(仁)）Liu et al., Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation. Science 387: eadn9390, 2025.

• 2025_0909（担当：榎内・佐藤(直)）Groos et al., A distinct hypothalamus–habenula circuit governs risk preference. Nat Neurosci 28(2): 361–373, 2025.

• 2025_0903（担当：相田・佐藤(仁)・石黒）Ongaro et al., Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. Science 387: 329–336, 2025.

• 2025_0825（担当：武田・小島）Cai et al., The gut microbiota promotes pain in fibromyalgia. Neuron 113 (13): 2161–2175, 2025.

• 2025_0526（担当：山本）Alexander et al., Orexin neurons mediate temptation-resistant voluntary exercise. Nat Neurosci 27(9): 1774–1782, 2024.

• 2025_0514（担当：青栁・下重）Williamson et al., Learning-associated astrocyte ensembles regulate memory recall. Nature 637: 478–486, 2025.

• 2025_0416（担当：小林）Ko et al., Processing of pain and itch information by modality-specific neurons within the anterior cingulate cortex in mice. Nat Commun 16(1): 2137, 2025.

• 2025_0402（担当：小島）Chien et al., MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model. Sci Transl Med 16(746): eadk8198, 2024.

2024年度

• 2025_0328（担当：青栁）Stokes et al., Cationic peptides cause memory loss through endophilin-mediated endocytosis. Nature 638: 479–489, 2025.

• 2025_0328（担当：武田）Han et al., Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice. Nat Commun 15: 4947, 2024.

• 2025_0314（担当：下重）Zhu et al., Sympathetic neuropeptide Y protects from obesity by sustaining thermogenic fat. Nature 634: 243–250, 2024.

• 2025_0313（担当：小林）Kobayashi et al., Revealing single-neuron and network-activity interaction by combining highdensity microelectrode array and optogenetics. Nat Commun 15: 9547, 2024.

• 2025_0312（担当：小島）Kim et al., Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors. Nat Neurosci 28: 336–345, 2025.

• 2025_0225（担当：大久保）Alexandre et al., Nociceptor spontaneous activity is responsible for fragmenting non–rapid eye movement sleep in mouse models of neuropathic pain. Sci Transl Med 16: eadg3036, 2024.

• 2025_0225（担当：武田）Lavaud et al., Two inhibitory neuronal classes govern acquisition and recall of spinal sensorimotor adaptation. Science 384: 194–202, 2024.

• 2025_0212（担当：青栁）Zhang et al., C-LTMRs evoke wet dog shakes via the spinoparabrachial pathway. Science 386(6722): 686–692, 2024.

• 2025_0212（担当：下重）Song et al., An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences. Nat Neurosci 27: 272–285, 2024.

• 2024_1217（担当：小島）Cahill et al., Network-level encoding of local neurotransmitters in cortical astrocytes. Nature 629: 146–153, 2024.

• 2024_1209（担当：青栁）Ojeda-Alonso et al., Sensory schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception. Nat Commun 15(1): 898, 2024.

• 2024_1203（担当：下重）Jin et al., A body–brain circuit that regulates body inflammatory responses. Nature 630(8017): 695-703, 2024.

• 2024_1128（担当：大久保）Walitt et al., Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome. Nat Commun 15: 907, 2024.

• 2024_1119（担当：武田）Cai et al., The kainate receptor GluK2 mediates cold sensing in mice. Nat Neurosci 27: 679–688, 2024.

• 2024_1114（担当：小林）Chen et al., Neural circuit basis of placebo pain relief. Nature 632: 1092–1100, 2024.

• 2024_0904（担当：小島・大久保・下重・青栁）Chu et al., ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain. Sci Adv 9: eade9931, 2023.

• 2024_0826（担当：武田・小林・小島）Benevento et al., A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure. Nature 628: 826–834, 2024.

• 2024_0528（担当：山本）Lu et al., CGRP sensory neurons promote tissue healing via neutrophils and macrophages. Nature 628: 604–611, 2024.

• 2024_0527（担当：八木）Bohic et al., Mapping the neuroethological signatures of pain, analgesia, and recovery in mice. Neuron 111: 2811–2830, 2023.

• 2024_0508（担当：二神）Chakrabarti et al., Touch sensation requires the mechanically gated ion channel ELKIN1. Science 383: 992–998, 2024.

2023年度

• 2024_0321（担当：八木）Tereshenko et al., Peripheral neural interfaces: Skeletal muscles are hyper-reinnervated according to the axonal capacity of the surgically rewired nerves. Sci Adv 10(9): eadj3872, 2024.

• 2024_0313（担当：山本）Wong et al., 4E-BP1–dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling. Sci Adv 9(44): eadh9603, 2023.

• 2024_0306（担当：二神）Zhang et al., Cortical regulation of helping behavior towards others in pain. Nature 626: 136–144, 2024.

• 2024_0209（担当：八木）Bayrer et al., Gut enterochromaffin cells drive visceral pain and anxiety. Nature 616: 137–142, 2023.

• 2024_0111（担当：山本）Albisetti et al., Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold. Neuron 111: 92–105, 2023.

• 2023_1129（担当：二神）Chantranupong et al., Dopamine and glutamate regulate striatal acetylcholine in decision-making. Nature 621: 577–585, 2023.

• 2023_1123（担当：八木）Gan et al., Layer-specific pain relief pathways originating from primary motor cortex. Science 378: 1336–1343, 2023.

• 2023_0921（担当：二神）Zhou et al., A sleep-active basalocortical pathway crucial for generation and maintenance of chronic pain. Nat Neurosci 26: 458–469, 2023.

• 2023_0915（担当：山本）Cheng et al., Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits. Neuron 111: 1301–1315, 2023.

• 2023_0728（担当：明）Stegemann et al., Prefrontal engrams of long-term fear memory perpetuate pain perception. Nat Neurosci 26: 820–829, 2023.

• 2023_0607（担当：野原）Xie et al., Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity. Neuron 111: 526–538. e4, 2023. 

• 2023_0531（担当：野村）Hsueh et al., Cardiogenic control of affective behavioural state. Nature 615: 292–299, 2023.