トップジャーナルから世界最先端の知見を読み込み発表することで、サイエンスの眼(芽)を育み、医療現場で役立つ情報収集能力や英語力、プレゼンテーションスキルの向上を目指しています!
この日は小島さんが、痛み刺激で活性化する脳の神経回路に関する論文を紹介してくれました。途中、ホワイトボードに神経経路の解剖図を描きながら、わかりやすく説明してくれました(2025_0312)
この日は小林さんが、神経ネットワークの新しい解析法に関する論文を紹介してくれました(2025_0313)
2025年度
2025_1121(担当:大久保)Argiro et al., Gastruloids are competent to specify both cardiac and skeletal muscle lineages. Nat Commun 15: 10172, 2024.
2025_1114(担当:石黒)Hakim et al., Macrophages protect against sensory axon loss in peripheral neuropathy. Nature 640 (8057): 212–220, 2025.
2025_1114(担当:佐藤(仁))Liu et al., Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation. Science 387: eadn9390, 2025.
2025_0909(担当:榎内・佐藤(直))Groos et al., A distinct hypothalamus–habenula circuit governs risk preference. Nat Neurosci 28(2): 361–373, 2025.
2025_0903(担当:相田・佐藤(仁)・石黒)Ongaro et al., Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. Science 387: 329–336, 2025.
2025_0825(担当:武田・小島)Cai et al., The gut microbiota promotes pain in fibromyalgia. Neuron 113 (13): 2161–2175, 2025.
2025_0526(担当:山本)Alexander et al., Orexin neurons mediate temptation-resistant voluntary exercise. Nat Neurosci 27(9): 1774–1782, 2024.
2025_0514(担当:青栁・下重)Williamson et al., Learning-associated astrocyte ensembles regulate memory recall. Nature 637: 478–486, 2025.
2025_0416(担当:小林)Ko et al., Processing of pain and itch information by modality-specific neurons within the anterior cingulate cortex in mice. Nat Commun 16(1): 2137, 2025.
2025_0402(担当:小島)Chien et al., MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model. Sci Transl Med 16(746): eadk8198, 2024.
2024年度
2025_0328(担当:青栁)Stokes et al., Cationic peptides cause memory loss through endophilin-mediated endocytosis. Nature 638: 479–489, 2025.
2025_0328(担当:武田)Han et al., Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice. Nat Commun 15: 4947, 2024.
2025_0314(担当:下重)Zhu et al., Sympathetic neuropeptide Y protects from obesity by sustaining thermogenic fat. Nature 634: 243–250, 2024.
2025_0313(担当:小林)Kobayashi et al., Revealing single-neuron and network-activity interaction by combining highdensity microelectrode array and optogenetics. Nat Commun 15: 9547, 2024.
2025_0312(担当:小島)Kim et al., Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors. Nat Neurosci 28: 336–345, 2025.
2025_0225(担当:大久保)Alexandre et al., Nociceptor spontaneous activity is responsible for fragmenting non–rapid eye movement sleep in mouse models of neuropathic pain. Sci Transl Med 16: eadg3036, 2024.
2025_0225(担当:武田)Lavaud et al., Two inhibitory neuronal classes govern acquisition and recall of spinal sensorimotor adaptation. Science 384: 194–202, 2024.
2025_0212(担当:青栁)Zhang et al., C-LTMRs evoke wet dog shakes via the spinoparabrachial pathway. Science 386(6722): 686–692, 2024.
2025_0212(担当:下重)Song et al., An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences. Nat Neurosci 27: 272–285, 2024.
2024_1217(担当:小島)Cahill et al., Network-level encoding of local neurotransmitters in cortical astrocytes. Nature 629: 146–153, 2024.
2024_1209(担当:青栁)Ojeda-Alonso et al., Sensory schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception. Nat Commun 15(1): 898, 2024.
2024_1203(担当:下重)Jin et al., A body–brain circuit that regulates body inflammatory responses. Nature 630(8017): 695-703, 2024.
2024_1128(担当:大久保)Walitt et al., Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome. Nat Commun 15: 907, 2024.
2024_1119(担当:武田)Cai et al., The kainate receptor GluK2 mediates cold sensing in mice. Nat Neurosci 27: 679–688, 2024.
2024_1114(担当:小林)Chen et al., Neural circuit basis of placebo pain relief. Nature 632: 1092–1100, 2024.
2024_0904(担当:小島・大久保・下重・青栁)Chu et al., ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain. Sci Adv 9: eade9931, 2023.
2024_0826(担当:武田・小林・小島)Benevento et al., A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure. Nature 628: 826–834, 2024.
2024_0528(担当:山本)Lu et al., CGRP sensory neurons promote tissue healing via neutrophils and macrophages. Nature 628: 604–611, 2024.
2024_0527(担当:八木)Bohic et al., Mapping the neuroethological signatures of pain, analgesia, and recovery in mice. Neuron 111: 2811–2830, 2023.
2024_0508(担当:二神)Chakrabarti et al., Touch sensation requires the mechanically gated ion channel ELKIN1. Science 383: 992–998, 2024.
2023年度
2024_0321(担当:八木)Tereshenko et al., Peripheral neural interfaces: Skeletal muscles are hyper-reinnervated according to the axonal capacity of the surgically rewired nerves. Sci Adv 10(9): eadj3872, 2024.
2024_0313(担当:山本)Wong et al., 4E-BP1–dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling. Sci Adv 9(44): eadh9603, 2023.
2024_0306(担当:二神)Zhang et al., Cortical regulation of helping behavior towards others in pain. Nature 626: 136–144, 2024.
2024_0209(担当:八木)Bayrer et al., Gut enterochromaffin cells drive visceral pain and anxiety. Nature 616: 137–142, 2023.
2024_0111(担当:山本)Albisetti et al., Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold. Neuron 111: 92–105, 2023.
2023_1129(担当:二神)Chantranupong et al., Dopamine and glutamate regulate striatal acetylcholine in decision-making. Nature 621: 577–585, 2023.
2023_1123(担当:八木)Gan et al., Layer-specific pain relief pathways originating from primary motor cortex. Science 378: 1336–1343, 2023.
2023_0921(担当:二神)Zhou et al., A sleep-active basalocortical pathway crucial for generation and maintenance of chronic pain. Nat Neurosci 26: 458–469, 2023.
2023_0915(担当:山本)Cheng et al., Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits. Neuron 111: 1301–1315, 2023.
2023_0728(担当:明)Stegemann et al., Prefrontal engrams of long-term fear memory perpetuate pain perception. Nat Neurosci 26: 820–829, 2023.
2023_0607(担当:野原)Xie et al., Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity. Neuron 111: 526–538. e4, 2023.
2023_0531(担当:野村)Hsueh et al., Cardiogenic control of affective behavioural state. Nature 615: 292–299, 2023.