Tranexamic Acid (TXA)

1. Follow General Trauma Protocol

2. Inclusion criteria

a. Adult (18 y/o or older) trauma patient with known or suspected hemorrhage

i. Intra-thoracic, intra-abdominal, pelvic or long bone fractures

b. Systolic blood pressure < 90 mmHg OR heart rate > 100 OR both

c. Time of injury < 3 hours

3. Contraindications

a. Pediatric patients (< 18 y/o)

b. Isolated head trauma

c. Known thromboembolic disease (PE, DVT, MI)

d. Known hypersensitivity to tranexamic acid

e. No IV access (do not administer TXA via IO or IM routes)

4. Dosage

a. Infuse TRANEXAMIC ACID (TXA) 1,000 mg (1 gram) in 100 mL NS or D5W over 10 minutes

b. After the initial transfusion, if a transport time > 1 hour is anticipated, initiate a 2nd infusion as follows:

i. Infuse TRANEXAMIC ACID (TXA) 1,000 mg (1 gram) in 1,000 mL NS over 8 hours (125 mL/hr)

5. Documentation

a. Documentation should include rational for administration including vital signs prior to and after administration