The increase in overweight and obesity is a major concern with almost 2 in 3 (63%) of Australian adults now suffering from these debilitating conditions. Physical activity and food intake are the primary regulators of energy balance. The brain plays an important role in the regulation of food intake, thus increasing interest has been directed at unravelling the interplay between appetite regulating gut hormones and the central nervous system and weight management. This special seminar will provide participants with an overview of the latest research and clinical applications of the role of gut hormones in appetite regulation and weight management.