A pandemic refers to a widespread infectious disease outbreak from bacteria or viruses, that are associated with the rapid spread of the infection globally. They often occur when people come together in contact with the disease when economic, social, and environmental changes happen. Pandemics have the ability to cause traumatic health impacts and are a reminder of the interconnectedness of the world because the infectious disease has the capability to cross into other regions without a physical barrier. Some regions in the world have a higher chance for an outbreak to happen and spread to and from, due to the size and density of the population. Different types of infectious disease can cause some pandemics to be more severe than others if the bacteria or virus is more transmittable between people. Infectious diseases are often seen along routes of transportation and trade throughout history and as the world becomes increasingly more interconnected.
Plague & Severe Acute Respiratory Syndrome
Throughout recorded history, the deadliest disease, the plague, has resurfaced numerous times, and of these occurrences, three are categorized as pandemics. The plague is an infectious disease caused by Yersinia pestis, a bacteria, usually found in small mammals and the fleas on them. The small mammals infected with Y. pestis transmit to fleas and then to other animals. These other animals come into close contact with humans and then infect them with the plague. The three modes of transmission are by flea bites, coming into contact with contaminated fluid or tissue or infectious droplets.
The first time the plague appeared was in the 6th century and is known as the Plague of Justinian. The plague was carried from Egypt into Europe with infected rats on merchant ships. People were traveling between the two regions because the Byzantine Empire, under the rule of Emperor Justinian, recently conquered Egypt. Eventually the plague reached the capital of the Byzantine Empire, Constantinople, in 541 CE. The plague destroyed the population living in Constantinople and swept across Europe, Asia, North Africa, and Arabia. People knew that the best way they could protect themselves from the plague was to avoid sick people; however, this did not prevent people from still becoming infected. It killed an estimate of 30-50 million people by the 8th century when it seemed to disappear.
The next pandemic of the plague re-emerged in China in the 1300s and 1350s. This plague pandemic was known as the Great Mortality during the time and later renamed the Black Death. The plague outbreak moved west along the Silk Road towards the Mediterranean Sea and the Black Sea, both primarily used for the transportation of goods and people to and from Europe. The city of Kaffa on the Crimean Peninsula of the Black Sea, was a large trading post for the Silk Road. Once cases of the plague began to emerge and the war between the Mongolians and Genoese broke out, merchants in the area began to flee the city and traveled further west into the Mediterranean Sea. When ships began to arrive at ports on islands off of Italy, people were discovering ships full of corpses with a few remaining survivors. Shortly after merchant ships reached the islands of Italy, the plague infested ships started to land on the harbors of mainland Italy and other areas on the continent of Europe. Once the plague reached Rome and Florence, two cities at the center of a trading network in Europe, the Black Death began to spread more quickly than before as more people were fleeing the cities that became infected. After people learned about how the plague was arriving in their port cities, they quarantined the merchants before allowing them onto land and then evaluating anyone who had symptoms of being sick. Some cities in Europe had higher mortality rates, while some seemed to remain relatively unaffected. It is estimated between 30-60% of the population living in Europe died because of the Black Death between 1347-1351. However, with proper record keeping the estimates could be narrowed to a specific range. The plague continued to reappear but did not cause as much damage to the population and did not spread as much.
The third pandemic of the plague erupted in 1855 in the Chinese province of Yunnan and also spread by infected rats on ships. This time the infected rats traveled on steamships to other countries and continents, killing around 15 million people before fading out in the 1950s. In 1894, a Hong Kong based doctor named Alexandre Yersin identified the bacteria that caused the Black Death, naming it bacillus Yersinia pestis. There are fewer people becoming infected from the plague. However, there is a possibility the world could experience another plague pandemic because the strain is still as deadly as before.
The initial response for Severe Acute Respiratory Syndrome (SARS) was limited, leading to an inevitable outbreak due to lack of preparedness and transparency. SARS is a viral respiratory illness that is caused by the coronavirus, called SARS-associated coronavirus (SARS-CoV). The transmission of SARS is believed to be from an animal virus that spreads between animal species in close proximity to one another and then onto infecting humans. Transmission is mainly from person to person in close contact after infecting the first humans. The virus is thought to be transmitted most easily by respiratory droplets produced when an infected person coughs or sneezes in close proximity to another person. Transmission of SARS is most infectious in the second week of having it, when the excretions from the body are at their peak.
In November of 2002, the first case of atypical pneumonia appeared in the Guangdong Province of Southern China. In the initial months of the outbreak, the Chinese were slow to report any cases because they were unsure about what they were dealing with and the possibility that the government suppressed doctors from reporting possible cases of the outbreak. A doctor who treated patients with SARS traveled to Hong Kong, China and unknowingly infected many people in the area, causing a start to the larger international population infection rate. From Hong Kong, the virus spread to Canada, Singapore, Vietnam, Taiwan, and many other countries. Out of the 29 countries affected by the pandemic of SARS, China and Hong Kong suffered the most infections and casualties. In China there were 5,327 cases and 349 fatalities and Hong Kong had 1,755 cases with 299 deaths. Worldwide SARS infected 8098 confirmed people with 774 deaths in the 2002-03 pandemic. Most of the cases of human transmission occurred in the healthcare setting, which lacked adequate infection control precautions. Once hospitals and other healthcare facilities began to implement appropriate infection control practices, the global number of cases slowed. In 2003 scientists discovered that SARS virus was possibly transmitted from bats to civet cats and then onto humans. With more knowledge of SARS and the quarantining and international cooperation in effect, the pandemic was brought to an end in July 2003.
The level of preparedness for pandemics has improved on the world distribution of SARS global scale. ~Anne W. Rimoin
As a result of the SARS pandemic, more people have become aware of the threat of biological infections and the damage they harm, if they are severe and untreated immediately. According to Anne W. Rimoin, a professor of epidemiology, the level of preparedness for pandemics has improved on the global scale. The world learned that the government and healthcare need to have more transparency between each other with their citizens to inform the possibility of other outbreaks. After officials stated the pandemic ended, there have been only three times that people caught the virus in the laboratory setting, when epidemiologists discovered that SARS-CoV caused Severe Acute Respiratory Syndrome. As a result, it is highly unlikely that SARS will return as a pandemic.
Increased mobility and global connectedness
An increase in the amount of people living closer to one another
Poor sanitation conditions
People have different understanding on how humans become infected during the outbreak of the pandemic
Some of the reporting of cases are unknown:
Plague: Record keeping was not as advanced as now
SARS: Slow initial reporting
During times of pandemics, people are sometimes targeted or blamed for the cause and/or spread of the disease
Black Death: Jewish People
SARS: Chinese for not reporting properly
Infectious diseases, like the plague and SARS, originate in bacteria and viruses, transmit to animals, and then evolve from animal diseases to human ones. Pandemics usually appear in areas of high population densities in close proximity with a variety of species. When an outbreak of an infectious disease spreads, societies try to avoid the sick, prevent the transportation of people from the source of the outbreak, quarantine themselves from others, and have incubation periods for people that are suspected of the disease. Pandemics develop and spread through the multifaceted mixture of social, biological, environmental, and political forces. Understanding the vulnerability of infectious disease can help lead to lowering the amount of cases that appear in the next possible outbreak in the globalizing world.