Mammalian cell culture is an important technique to cellular & molecular biology research; however, supplementary hormones and nutrition are required for cells to grow in vitro. The gold-standard source of these is Fetal Bovine Serum (FBS), but FBS is expensive, can make experiments hard to reproduce, can introduce contaminants to cell cultures, and can be ethically dubious. Therefore, researchers are innovating potential alternatives targeted at these issues. A promising avenue is using extracts derived from various algaes—a more cost-effective, sustainable, and ethical source. The origin of this research is based on Chlorella vulgaris extract, which is a popular human health supplement. Application of this extract to Chinese Hamster Ovary (CHO) cells as a supplement to FBS, but not a replacement, proved somewhat effective. Since then, several other algae extracts have been investigated, including from the micro-algae Galdieria sulphuraria as part of Project SerAZel at the Hochschule Bremerhaven. While not an immediately obvious choice, G. sulphuraria has shown promise as an FBS alternative/supplement. Ongoing research is still being conducted so that G. sulphuraria extracts could be viable as an FBS replacement. One reason this micro-algae is attractive is that it is an extremophile—growing in conditions that are cost-effective and resistant to contamination. While working on Project SerAZel, my focus was on the use of anion-exchange chromatography as a method of further protein purification from G. sulphuraria extracts to improve their effectiveness.