Tuberculosis, a bacterial infection caused by Mycobacterium tuberculosis, has devastated human populations since prehistory. While it is a disease that first affects the respiratory system, through its eventual consumption of organ systems, it also leaves traceable signs on the human skeleton.  Using paleopathological methods to study human remains is a viable way to investigate how tuberculosis has evolved the biological repercussions of the disease. This study provides a secondary analysis of paleopathology of tuberculosis using two main case studies to examine the skeletal manifestations of the disease on human remains. The two major case studies that examined in depth deal with human remains from the breadth of human history: one an Egyptian mummy and the other an assemblage from England dating from the 19th century. The methodology of studying skeletal tuberculosis is also explored, as new methods of threshold diagnosis profiling, DNA amplification, and microscopy of the skeleton have become more sophisticated in the last 25 years. These methods and what additional biological information they provide about tuberculosis are explored within this study. It aims to provide insights into the value of studying the biology of tuberculosis and how it leaves traces upon the human skeleton, which may provide bioarcheologists with vital clues in understanding the effects of the disease on the lives of so many in the past and present.