The U.S. Centers for Disease Control and Prevention (CDC) estimates that 2.8 million antibiotic-resistant infections occur in the U.S each year, resulting in 35,000 deaths. Bacteria have a multitude of ways of resisting antibiotics. One of these mechanisms is pumping the drug out of the cell via efflux pumps, which is believed to be the most common mode of antibiotic resistance. Figure 1 shows the six type of bacterial efflux pumps. Antibiotic resistance occurs via genes that are passed down on plasmids via horizontal gene transfer. Bacteria can regenerate rapidly, sometimes in as little as twenty minutes, meaning that widespread use of a drug can lead to antibiotic resistance in just a few years..  This is a very prevalent issue because antibiotic resistance makes antibiotic drugs less effective, and results in bacterial infections being increasingly difficult to treat. This rise of antibiotic resistance has made it essential to find new compounds that have the ability to act as antimicrobials. In this poster, I will be writing a comprehensive literature review that analyzes how essential oils and non-antibiotic compounds can aid in the fight against antibiotic resistance.