Bird flu, or Highly Pathogenic Avian Influenza (HPAI) has had a massive impact on wild bird conservation, human food security, and even to human health. The virus mutates frequently due to waterfowl migration. Interactions between infected wild waterfowl and domestic poultry lead to mass die-offs at farms, which leads to food insecurity in areas where people rely on that meat as a main food source. Clinical signs of HPAI include lethargy, corneal edema, congestion, diarrhea, and neurological signs like head tremors that worsen until the bird dies. Human infection of HPAI is rare, but when it has occurred, the mortality rate can be as high as 60%. Due to the high rate of mutation with the virus, there is a large risk that the virus could mutate to a strain that can be easily passed from human to human. This could easily lead to another pandemic. Current research is focusing on predicting how this spill-over event could occur, and creating potential vaccines to prepare for this possibility.