CRISPR-Cas9 Gene Editing in Human Embryos (Scientific and Policy Implications)
CRISPR-Cas9 Gene Editing in Human Embryos (Scientific and Policy Implications)
About Me
I am from the Bronx, New York, and I am a Biology major with a Biochemistry emphasis on the pre-med track at Macalester College. I am motivated by the impact science can have on improving people’s lives, especially in underserved communities like the one I come from. In Spring 2025, I took an Advanced Genetics course where I wrote a policy report on CRISPR-Cas9 embryo editing. I was fascinated by the scientific potential of gene editing to prevent genetic diseases, while also wanting to explore the ethical concerns and alternative approaches that should be considered. I am especially excited about the future of genetics and personalized medicine, and after graduation I hope to gain clinical experience in a hospital while applying to medical school, continuing my goal of becoming a physician who combines science, ethics, and compassionate care.
Abstract
CRISPR-Cas9 is a genome-editing technology that allows scientists to make targeted changes to DNA. Because many genetic diseases are caused by single mutations, CRISPR has been proposed as a way to prevent inherited disorders at the embryonic stage. However, when gene editing is performed in human embryos, the changes become part of the germline and are passed to future generations. This raises both scientific and ethical concerns. In this presentation, I first explain how CRISPR-Cas9 works at the molecular level, including guide RNA targeting, DNA cleavage, and the cellular repair pathways that follow. I focus especially on how rapid cell division in early embryos can lead to mosaicism and unintended mutations. Second, I examine historical and bioethical implications, including the 2018 case of embryo gene editing that prompted global concern. This case demonstrated how scientific capability can advance faster than ethical consensus and regulatory oversight. Finally, I discuss alternative approaches, such as preimplantation genetic testing, and newer precision editing technologies that aim to reduce DNA damage. Overall, while CRISPR-Cas9 represents a major advancement in genetic medicine, its use in human embryos remains scientifically limited and ethically complex.