Control Systems in Synthetic Biology
Tutorial will be held during the IFAC World Congress 2023 in Yokohama, Japan
Date/Time: 13:30-17:00 13:30-16:15, July 9th, 2023
Place: Room 512 (PACIFICO Yokohama, Yokohama, Japan)
Organizers: Mustafa Khammash (ETH Zürich), Yutaka Hori (Keio University)
Registration: Please register from the conference registration website
Please choose "Control Systems in Synthetic Biology" from the dropdown menu in the "Select Events" tab to attend this tutorial (Tutorial is included in regular/student registration)
This tutorial session aims to give the control community an accessible and inspiring introduction to Cybergenetics—a nascent field at the interface between control engineering and synthetic biology concerned with the development of the theoretical and experimental methodologies required for engineering molecular control systems.
Schedule of the event (Finalized)
The session is divided into three thematic parts. The parts are very closely connected and will be tightly integrated. The thematic parts and tentative schedule are:
13:30-14:15 Background and Introduction
Biological background (cells, genes, RNAs, protein, gene expression, gene regulation)
Genetic engineering (how to build circuits)
Genetic circuits
Mathematical modeling
Overview of current challenges and opportunities
14:15-15:00 Control Systems for Living Cells
Genetic control circuits
Computer control of circuits
Multicellular control
Challenge, opportunities, and open questions
15:00-15:30 Cofee Break (4th floor)
15:30-16:15 Cell-free Circuits & Communication Systems for Living Cells
Cell-free circuits and control
Circuit prototyping with examples
Communication systems in biology
Challenge, opportunities, and open questions
Speakers
Mustafa Khammash
Mustafa Khammash is Professor of Control Theory and Systems Biology at the Department of Biosystems Science and Engineering (D-BSSE) at ETH Zürich. After receiving his Ph.D. in Electrical Engineering from Rice University in 1990, he joined the Electrical Engineering Department at Iowa State University (ISU). While at ISU, he created the Dynamics and Control Program and led that control group until 2002, when he joined the faculty of the University of California, Santa Barbara. In Santa Barbara, he served as Vice Chair of the Mechanical Engineering Department from 2003 to 2006 and as the Director of the Center for Control, Dynamical Systems and Computation from 2005 to 2011. In 2011 he moved with his group to Switzerland, joining the Department of Biosystems Science and Engineering at ETH Zurich. At ETH, he served as the department chair (2015-2017). Khammash is a Fellow of the IEEE (2007), the International Federation of Automatic Control (2010), and the Japan Society for the Promotion of Science (2003). He is a winner of the ISU Early Achievement in Research and Scholarship Award, the Young Engineering Research Faculty Award, the ETH Golden Owl Award, and the European Research Council Advanced Grant. Dr. Khammash works at the interface of the areas of control theory, systems biology, and synthetic biology. His research aims to understand the role of dynamics, feedback, and randomness in biology, and to develop the tools needed to aid in this understanding. Khammash’s group is currently developing the theory, computational methods, and experimental tools for controlling living cells using both computer and molecular control systems.
Yutaka Hori
Yutaka Hori received the B.S degree in engineering, and the M.S. and Ph.D. degrees in information science and technology from the University of Tokyo in 2008, 2010 and 2013, respectively. He held a postdoctoral appointment at California Institute of Technology from 2013 to 2016. In 2016, he joined Keio University, where he is currently an associate professor. His research interests lie in feedback control theory and its applications to synthetic biomolecular systems. He is a recipient of Takeda Best Paper Award from SICE in 2015, and Best Paper Award at Asian Control Conference in 2011, and is a Finalist of Best Student Paper Award at IEEE Multi-Conference on Systems and Control in 2010. He has been serving as an associate editor of the Conference Editorial Board of IEEE Control Systems Society. He is a member of IEEE, SICE, and ISCIE.