Rini Riyanti
Department of Clinical Pathology, Faculty of Medicine, University of Jember, Jember, Indonesia

Muhammad Ali Shodikin
Department of Pediatrics, Faculty of Medicine, University of Jember, Jember, Indonesia

Sheilla Rachmania
Department of Histology, Faculty of Medicine, University of Jember, Jember, Indonesia

Rosita Dewi
Department of Histology, Faculty of Medicine, University of Jember, Jember, Indonesia

DOI: https://doi.org/10.19184/ams.v11i2.50026

Abstract

Dengue infection is a disease caused by dengue virus infection and transmitted by the Aedes mosquito, and is a major health problem in children, especially in developing countries. The Platelet-to-Lymphocyte Ratio (PLR) is a novel inflammatory biomarker that has recently been frequently studied and play a role in the assessment of dengue severity viral infection, and Research has indicated that the PLR (Platelet-to-Lymphocyte Ratio) may offer a more effective comparison for assessing the severity of viral infectious diseases when contrasted with the Neutrophil-to-Lymphocyte Ratio (NLR). Research suggests that the Platelet-to-Lymphocyte Ratio (PLR) could serve as a promising biomarker for assessing the severity of dengue infections. This is particularly advantageous for developing countries, as PLR is an inexpensive and readily available measure in various clinical settings. This research is a correlative analytical observational study using a cross-sectional approach. This research design was carried out by collecting data from children diagnosed with dengue infection as well as data on platelets and lymphocytes on the first day of admission to the hospital. This research uses stratified random sampling. Data were analyzed using Spearman correlation with a confidence level of 99%. The results of Spearman's correlation analysis showed a strong significant relationship with p<0.01 (p=0.000) and a correlation coefficient of - 0.753. In conclusion, there is a significant relationship between the Platelet-to-Lymphocyte Ratio (PLR) value with the severity of dengue infection in pediatric patients RSUD Dr. Soebandi Jember.

Keyword: PLR; dengue infection; children; platelets; lymphocytes.

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