We are an interdisciplinary research group at the Institute of Chemistry of UNAM in Mexico City developing small molecule fluorescent probes for imaging intracellular communication through physical, chemical and physicochemical parameters. Our research program involves several disciplines ranging from synthesis and molecular spectroscopy to functional fluorescence microscopy and super-resolution microscopy.
1. Flores-Cruz, R.; Hernández-Juárez, C.; Jiménez-Sánchez, A. Fluorescent Probe for the Monitoring of Plasma Membrane Hydration. Eur. J. Org. Chem. 2022, DOI: 10.1002/ejoc.202200626. “Selected in the “Organic and Supramolecular Chemistry in Latin America” special collection.
2. Bernal-Escalante, J.; Molina-Villa, T.; López-Casillas, F.; Jiménez-Sánchez, A. Mitochondria-Assisted Photooxidation to Track Singlet Oxygen at Homeostatic Membrane Order. ACS Sens. 2022, 7, 2303-2311.
3. Hernández-Juárez, C.; Flores-Cruz, R.; Jiménez-Sánchez, A. Fluorescent probe for early mitochondrial voltage dynamics. Chem. Commun. 2021, 57, 5526-5529. “Selected in the 2021 Emerging Investigators” theme collection.
4. Palacios-Serrato, E.; Araiza-Olivera, D.; Jiménez-Sánchez, A. Fluorescent Probe for Transmembrane Dynamics During Osmotic Effects. Anal. Chem. 2020, 92, 3888–3895.
5. Labra-Vázquez, P.; Flores-Cruz, R.; Galindo, A.; Cabrera, J.; Guzmán, C.; Jiménez-Sánchez, A.; Lacroix, P.; Santillan, R.; Farfán, N.; Núñez, R. Tuning the Cell Uptake and Subcellular Distribution in BODIPY– Carboranyl Dyads: An Experimental and Theoretical Study. Chem. Eur. J. 2020, 26, 16530 – 16540.
6. Trejo-Huizar, K. E.; Jiménez-Sánchez, A.; Yatsimirsky, A. Composition, stability and fluorescence properties of metal complexes of an aza-flavonol analog 1-methyl-2-phenyl-3-hydroxy-4(1H)-quinolone in aqueous solution. Inorg. Chim. Acta, 2020, 505, 119471
7. Amador-Sanchez, Y. A.; Aguilar-Granada, A.; Flores-Cruz, R.; González-Calderón, D.; Orta, C.; Rodríguez-Molina, B.; Jiménez-Sánchez, A.; Miranda, L. D. Diversity-Oriented Synthesis of Highly Fluorescent Fused Isoquinolines for Specific Subcellular Localization. J. Org. Chem. 2019, 85, 633-649
8. Bernal Escalante, J.; López Vázquez, Jorge A.; Araiza Olivera, D. and Jiménez-Sánchez, A. Organotin(IV) Differential Fluorescent Probe for Controlled-Subcellular Localization and Nuclear Microviscosity Monitoring. Chem. Commun., 2019, 55, 8246-8249. .
9. Flores-Cruz, R.; López Arteaga, R.; Ramírez-Vidal, L.; López-Casillas, F.; Jiménez-Sánchez, A. Unravelling the Modus-Operandi of Chromenylium-Cyanine Fluorescent Probes: A Case Study. Phys. Chem. Chem. Phys. 2019, 21, 5779-15786.
10. Trejo-Huizar, K. E.; Jiménez-Sánchez, A.; Yatsimirsky, A. Composition, stability and fluorescence properties of metal complexes of an aza-flavonol analog 1-methyl-2-phenyl-3-hydroxy-4(1H)-quinolone in aqueous solution. Inorg. Chim. Acta, 2020, 505, 119471.
Mon, 12 Nov 2018. Our Publication in ChemComm is online now! - Tracking Mitochondrial 1O2-ROS Production Through a Differential Mitochondria-Nucleoli Fluorescent Probe. Chem. Commun. 2018, DOI: 10.1039/C8CC08289H
Mon, 28 May 2018. Publication in Angewandte Chimie International Edition - A Multifunctional Chemical Probe for Local Micropolarity and Microviscosity in Mitochondria: Angew. Chem. Int. Ed. 10.1002/anie.201802796
Fri, 25 May 2018. The group thanks to all the IofC academic staff and committee for their contributions in my research seminar.
Sun, 18 Feb 2018. Leaving for Berkeley, we are proud to participate in the Berkeley Global Science Institute – UC Berkeley and the Institute of Chemistry of UNAM.
Mon, 30 Oct 2017. We welcome Ricardo Flores, Faculty of Chemistry at UNAM, the first PhD student in our lab.
Fri, 01 Sep 2017. From Toronto to UNAM. The lab at the Institute of Chemistry (IofC) is not operational, yet.