Exploration domains

Borono-Peptide Chemical Biology

We are a passionate and driven team, diving into science with enthusiasm for both reading and researching, as we explore innovative chemistries to tackle pressing public health challenges. AB-Lab welcomes students with backgrounds in Organic, Bioorganic, Biochemistry, and Medicinal Chemistry who are eager to learn, collaborate, and contribute to interdisciplinary research at the intersection of Chemistry and Biology. We have high expectations for young scientists who aspire to make a groundbreaking impact and shape the future of science.

Research Interest 

Despite the vast array of molecular recognition techniques, medical diagnostics still heavily depend on antibodies, especially for targeting specific molecules. However, antibody-based therapies and diagnostics, including monoclonal antibodies, are notoriously expensive and come with various biological limitations. In contrast, peptides and mini-proteins offer a cost-effective and viable alternative in many biomedical applications. Yet, the discovery of peptide-based receptors that provide highly specific and tight binding remains a significant challenge. For example, peptide recognition of lipid and glycan biomarkers is still underdeveloped for medical use, despite its potential to aid in the detection and inhibition of cancer, viral infections, diabetes, and more. Similarly, designing peptide-based pharmacophores to target specific DNA sequences is a complex task, as is the detection of toxic metabolites critical for disease diagnosis and food safety. To address these challenges, our innovative peptide engineering approach will focus on developing peptide receptors with precise recognition capabilities for these urgent targets. By utilizing novel chemistries, our group aims to establish a platform that fosters specific molecular recognition, with the overarching goal of understanding cooperative molecular interactions, decoding mechanistic biology, and developing accessible biomedical tools.

The State of the Art

Research Projects

1. Revisiting and Improvising Chemical Tools for Chemical Biology

2. Biomimetic Approach in Receptor Design for Cancer Biomarkers 

3. Diagnostics and Therapeutics Discovery in the Treatment of Tropical Diseases

4. Ligation and Bioconjugation Chemistry

Target Biologics

Funding Support

Our Startup

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