THE Zebrafish Chemical Genetics Lab

current research interests

Neurodevelopmental disorders are those that result from defects in brain development. These include conditions such as Specific Learning Disorders (SLD), Attention Deficit and Hyperactivity Disorder (ADHD), Autism Spectrum Disorders (ASD) and Intellectual Disability.

Using zebrafish models of these diseases we aim to dig deeper into the brain pathologies. This means:

-Using genetic manipulations such as transgenics, antisense knockdowns and CRISPR-based mutations to perturb gene functions.

-Looking at neuronal and glial abnormalities in the brain

-Figuring out why the structural changes happened and what these changes do in the brain

-Creating behavioural correlates to assess the role of candidate genes

Zebrafish models of human diseases

CHARGE syndrome

Rubinstein Taybi Syndrome

Hereditary Hemochromatosis

Liver damage and Regeneration

Non-alcoholic Fatty liver disease

Chemical biology in zebrafish

Contact Us

Chetana Sachidanandan PhD

CSIR-Institute of Genomics and Integrative Biology, CSIR-IGIB South Campus, Mathura Road, Near Sukhdev Vihar & CSIR-CRRI, New Delhi 110025, Phone: +91-11-29879-105, chetana@igib.in, chetana@igib.res.in