Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2D) are both age-related disorders, and their prevalence is rising globally. Cyclin-dependent kinase 5 (CDK5) is a pivotal regulator of neuronal signal transduction and its activator p35 is predominantly present in neurons and pancreas. Cdk5 can be a potent link between T2D and cognitive impairment as this kinase plays a critical role in both disease types. We are, therefore, interested in understanding the specific neural circuits and/or molecular pathways that are primarily targeted in Type 2 Diabetes related neurodegeneration and how they can be restored. Currently, we are evaluating whether CDK5 plays a role in cognition and synaptic plasticity in diabetes mellitus.