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Dr. Steven Aaron Rosenberg (born 1940)

Portrait: Dr. Steven Rosenberg Description: Portrait of Dr. Steven Rosenberg, Chief of the Clinical Center Research, CCR's Surgery Branch. See also http://ccr.cancer.gov/Staff/Staff.asp?StaffID=615.. Subjects (names): Rosenberg, Steven Topics/Categories: National Cancer Institute -- People Type: Color Source: National Cancer Institute Author: Rhoda Baer (Photographer)Date Created: July 24, 2008 [HK008V][GDrive]

Wikipedia 🌐 Steven Rosenberg

ASSOCIATIONS

Cetus Corporation ( " By 1983 [Cetus Corporation] created a proprietary recombinant version of IL2 and collaborated with [Dr. Steven Aaron Rosenberg (born 1940)] to begin clinical trials" [HK008G][GDrive] )
Dr. William French Anderson (born 1936) ( First gene therapy : "Anderson teamed with [Dr. Robert Michael Blaese (born 1939)], a prominent immunologist in the National Cancer Institute (NCI), and [Dr. Steven Aaron Rosenberg (born 1940)], a prominent cancer surgeon and immunotherapy advocate, also in the NCI." [HK0091][GDrive] )
Dr. Robert Michael Blaese (born 1939) ( First gene therapy : "Anderson teamed with [Dr. Robert Michael Blaese (born 1939)], a prominent immunologist in the National Cancer Institute (NCI), and [Dr. Steven Aaron Rosenberg (born 1940)], a prominent cancer surgeon and immunotherapy advocate, also in the NCI." [HK0091][GDrive] )

ALSO SEE

Gene therapy history

Saved Wikipedia (Dec 09, 2021) - "Steven Rosenberg"

Source : [HK008U][GDrive]

Born

August 2, 1940 (age 81)

Alma mater

The Johns Hopkins University

Harvard University

Scientific career

Thesis

The proteins of human erythrocyte membranes (1969)

Steven A. Rosenberg (born 2 August 1940^[1]) is an American cancer researcher and surgeon, chief of Surgery at the National Cancer Institute in Bethesda, Maryland and a Professor of Surgery at the Uniformed Services University of Health Sciences and the George Washington University School of Medicine and Health Sciences. He pioneered the development of immunotherapy that has resulted in the first effective immunotherapies and the development of gene therapy. He is the first researcher to successfully insert foreign genes into humans.

Early life[edit]

Rosenberg was born in 1940, in the Bronx, the youngest of three children of Jewish immigrants from Poland,^[2][1] who owned a luncheonette. He met his wife to be, Alice O’Connell during his residency at Boston’s Peter Bent Brigham Hospital, who was the chief nurse at the time. They got married in 1968 and have three daughters.^[1]

Methodology[edit]

He is accredited with developing the use of IL-2 and immune cells for the treatment of patients with melanoma in a procedure termed adoptive cell transfer. He has shown that expanding immune cells (known as tumor infiltrating lymphocytes) in the lab can be used to treat patients with melanoma and has published two important studies describing their use. The first in 2002, demonstrated that some patients with advanced melanoma can be treated to complete remission with a combination of chemotherapy, immune cells and high doses of IL-2.^[3] The second, in 2006, demonstrated that the receptor of T cells can be transferred to immune cells and in combination with chemotherapy and high doses of IL-2 can be used to treat patients with melanoma.^[4] Although, this was the first time that the T cell receptor was used for gene therapy, it was not the first time that gene therapy was used in cancer. Tumor cells modified with a gene for immune growth factors such as GM-CSF, had been used many years previously and continue to be used, although the efficacy of GM-CSF modified tumor lines as a cancer vaccine remain extremely modest, at best.^[5] There has been some debate as to the role of the T cells in treating the cancer in these studies as high-dose IL-2 and chemotherapy have also been shown to have anti-cancer properties. Nevertheless, the combination of chemotherapy, T cells and high-dose IL-2 was shown to be effective even in patients who had previously failed high-dose IL-2 treatment.

Rosenberg has pioneered the use of adoptive immunotherapy.

Education[edit]

Rosenberg graduated from the Bronx High School of Science. He received his B.A. (biology, 1961) and M.D. (1964) degrees from The Johns Hopkins University.^[1] He served a surgical internship and residency at the Peter Bent Brigham Hospital, completing it in 1974. During his residency he also earned a Ph.D. in biophysics from Harvard University with thesis titled The proteins of human erythrocyte membranes (in 1968/1969).^[1] Following the completion of his surgical residency, he became the Chief of Surgery at the National Cancer Institute a position he continues to hold.^[1] His research has focused on the immunotherapy of cancer.