Summaries / Proceedings : https://www.nap.edu/download/23484

USA Naitonal Academies of Sciences and Engineering

Gain-of-Function Research

Summary of the Second Symposium, March 10-11, 2016

2016-03-11-usa-gov-national-academies-gain-of-funciton-symposium-second-summary.pdf

2016-03-11-usa-gov-national-academies-gain-of-funciton-symposium-second-summary-cover.jpg

Youtube Channel Page : Live link - https://www.youtube.com/channel/UCBeoZcQRZ800s3bP2yJrFEw

Video 1 - "Welcome to the Symposium"

"Symposium planning chair Harvey Fineberg welcomes all attendees to the GOF symposium, along with Institute of Medicine President Victor Dzau."

Saved MP4 video (1080P) : [HV00JU][GDrive] / Live link : https://www.youtube.com/watch?v=vyFoJNfUmxg

Video 2 : "Session 1 Opening Remarks"

"Harvey Fineberg presents the goals of the symposium and a quick overview of international meetings on the same topic. Andrew Hebbeler and Mary Groesch present the current U.S. government policy on GOF research proposals and present the charge to the National Academies. Samuel Stanley presents a summary and response to the October 22, 2014 NSABB meeting."

Saved MP4 video (1080P) : [HV00JV][GDrive] / Live link : https://www.youtube.com/watch?v=6anWHbQXjjo

Video 3 : " Welcome and Opening Remarks"

"Harvey Fineberg (Session Moderator), Ralph Cicerone, Margaret Hamburg, Jo Handelsman and Carrie Wolinetz provide a welcome and opening remarks to the Gain of Function symposium."

Saved MP4 video (1080P) : [HV00JW][GDrive] / Live link : https://www.youtube.com/watch?v=NVJejL8U9Q0

Video 4 : "Overview of the Draft NSABB Policy Framework and Key Policy Questions"

" Harvey Fineberg (Session Moderator), Samuel Stanley, Joseph Kanabrocki and Kenneth Berns discuss the draft NSABB policy framework and key policy questions."

Saved MP4 video (1080P) : [HV00JX][GDrive] / Live link : https://www.youtube.com/watch?v=1WGLG9DooHw

Video 5 : " Session 2 Overview"

" Kanta Subbarao presents a general overview of what virology is, what impact it has on the viruses being studied, and where virology crosses the line into GOF research as defined by the U.S. government. Thomas Briese and Michael Imperiale respond to Dr. Subbarao's presentation and provide their own points of view. "

Saved MP4 video (1080P) : [HV00JY][GDrive] / Live link : https://www.youtube.com/watch?v=V8eMycauhhU

Video 6 : "Session 3 What is the debate on the potential risks and benefits of GOF research"

" Yoshihiro Kawaoka discusses the key issues on benefits that need to be addressed in the assessments the NIH will undertake, while David Relman discusses the key issues on risks."

Saved MP4 video (1080P) : [HV00JZ][GDrive] / Live link : https://www.youtube.com/watch?v=z5BJ5yBjShQ

Video 7 : " Session 4 Potential Benefits of GOF Research I Surveillance, Detection and Prediction"

" Philip Dormitzer moderates a session of talks including Stacey Schultz-Cherry discussing surveillance of emerging zoonotic diseases, Christophe Fraser discussing modeling of potential pandemics, and Colin Russell responding to both talks. "

Saved MP4 video (1080P) : [HV00K0][GDrive] / Live link : https://www.youtube.com/watch?v=mkS65OsYSzg

Video 8 : "Session 5 Potential Benefits of GOF Research II Treatment and Response"

" Baruch Fischhoff moderates a session in which a panel of academic, government and industry representatives discuss how GOF research could potentially benefit the acceleration of vaccine and antiviral development. The panel includes Philip Dormitzer (synthetic influenza vaccine viruses), Ralph Baric (vaccines targeting coronaviruses), Jerry Weir (regulatory perspective on viral manipulation for biologics), and Mark Denison (GOF research and countermeasures against SARS and MERS.) "

Saved MP4 video (1080P) : [HV00K1][GDrive] / Live link : https://www.youtube.com/watch?v=Aw-nR6-4kQQ

Video 9 : "Session 6 Potential Risks of GOF Research I Biosafety"

" Alta Charo moderates a panel discussing the potential for inadvertent releases, laboratory acquired infections, environmental health issues and risk mitigation. Panel includes Barbara Johnson, Rob Weyant, Rebecca Moritz and Marc Lipsitch. "

Saved MP4 video (1080P) : [HV00K2][GDrive] / Live link : https://www.youtube.com/watch?v=bV_gwKLVOzA

Video 10 : "Session 7 Potential Risks of GOF Research II Biosecurity"

" Ronald Atlas moderates a panel of experts discussing the potential risks of gain-of-function research from a biosecurity perspective. Panelists include Gregory Koblentz, Carol Linden and Gigi Kwik Gronvall. "

Saved MP4 video (1080P) : [HV00K3][GDrive] / Live link : https://www.youtube.com/watch?v=yOmAaQJ9ZVA

Video 11 : "Informing Policy Design Insights from the Science of Safety and the Science of Public Consultation"

" Baruch Fischhoff (Session Moderator), Ruthanne Huising, Gavin Huntley-Fenner and Monica Schoch-Spana discuss how the science of safety and public consultation can be integrated into the implementation of the risk-benefit assessment. "

Saved MP4 video (1080P) : [HV00K4][GDrive] / Live link : https://www.youtube.com/watch?v=xpZEoHJhrso

Video 12 : "Informing the Policy Framework The Risk Benefit Assessment"

" Charles Haas (Session Moderator), Rocco Casagrande, Louis (Tony) Cox, Adam Finkel, and Kara Morgan discuss lessons from the risk/benefit assessment and provide comments on it. "

Saved MP4 video (1080P) : [HV00K5][GDrive] / Live link : https://www.youtube.com/watch?v=7bP5wBZrQyg

Video 13 : "International Governance Opportunities for Harmonizing GOF Research Policy and Practice"

" Ronald Atlas (Session Moderator), Nisreen AL-Hmoud, George Gao, Gabriel Leung and Michael Selgelid present international perspectives on harmonizing global policies. "

Saved MP4 video (1080P) : [HV00K6][GDrive] / Live link : https://www.youtube.com/watch?v=yh_cphkfWHs

Video 14 : "Perspectives of Key Stakeholders in the Biomedical and Public Health Communities"

" Philip Dormitzer (Session Moderator), Michael Callahan, Robert Fisher, Jonathan Moreno, and Ethan Settembre present the perspectives of biomedical and public health personnel in regards to gain-of-function research."

Saved MP4 video (1080P) : [HV00K7][GDrive] / Live link : https://www.youtube.com/watch?v=rp3mHlfEcBY

Presenting : Dr. Michael Vincent Callahan (born 1962) /

Video 15 : "The Policy Landscape United States"

" Michelle Mello (Session Moderator), Gerald Epstein, Lawrence Kerr, Richard Frothingham and Philip Potter discuss and comment on the existing U.S. policy landscape in regards to gain-of-function research. "

Saved MP4 video (1080P) : [HV00K8][GDrive] / Live link : https://www.youtube.com/watch?v=XTZIO6w-Des

Video 16 : "The Policy Landscape International Dimensions of GOF Research"

" Barry Bloom (Session Moderator), Ruxandra Draghia-Akli, Volker ter Meulen, Silja Voneky and Keiji Fukuda discuss existing international policies in place regarding gain-of-function research. "

Saved MP4 video (1080P) : [HV00K9][GDrive] / Live link : https://www.youtube.com/watch?v=XC9VZiQh120

Video 17 : "Session 8 Models for Risk Benefit Assessment, Risk Mitigation, and Engaging the Public"

" Baruch Fischhoff presents on what risk/benefit assessment can and cannot do, as well as what we have learned from the past about strategies, pitfalls and limitations of risk and benefit assessments. Gavin Huntley-Fenner presents on the role of human factors. Monica Schoch-Spana presents on ensuring public engagement, and Ralph Baric and Robert Lamb present on any special considerations that need to be taken into account in creating the risk/benefit assessment. "

Saved MP4 video (1080P) : [HV00KA][GDrive] / Live link : https://www.youtube.com/watch?v=jfUTwoe7SvE

Video 18 : "Session 9 Summary Discussions"

" Harvey Fineberg, Ronald Atlas, Baruch Fischhoff, Chuck Haas and Alta Charo present rapporteur summaries on the following topics: potential risks, potential benefits, considerations/challenges for analysis of potential risks and benefits to inform broader assessments, and policy implications. "

Saved MP4 video (1080P) : [HV00KB][GDrive] / Live link : https://www.youtube.com/watch?v=tLRAIqW8cag

Video 19 : "Moderated Discussion - Session 10"

" The floor is opened for any and all comments to be made that have not previously been made or require further emphasis. "

Saved MP4 video (1080P) : [HV00KC][GDrive] / Live link : https://www.youtube.com/watch?v=nEwEf2HqrIk

Video 20 : "Sessions 10 and 11 Finding Common Ground and Chairman's Highlights"

" Harvey Fineberg closes the meeting with comments on common ground amongst the debate and chairman's highlights of the meeting. "

Saved MP4 video (1080P) : [HV00KD][GDrive] / Live link : https://www.youtube.com/watch?v=J76OThjlbLo

Video 21 : "Workshop Summary"

" Planning Committee Chair Harvey Fineberg and the planning committee members present their summation of the sessions over the two-day workshop, and Fineberg presents a summary of the workshop as a whole. "

Saved MP4 video (1080P) : [HV00KE][GDrive] / Live link : https://www.youtube.com/watch?v=5vJ4sFgQUcM