業績一覧

業績一覧　ウイルス研究

1. Ueno S, Amarbayasgalan S, Sugiura Y, Takahashi T, Shimizu K, Nakagawa K, Kawabata-Iwakawa R, Kamitani W. Eight-amino-acid sequence at the N-terminus of SARS-CoV-2 nsp1 is involved in stabilizing viral genome replication. Virology. 2024 Apr 8;595:110068. doi: 10.1016/j.virol.2024.110068. Online ahead of print. PMID: 38593595

2. Takahashi T, Ueno S, Sugiura Y, Shimizu K, Kamitani W. Establishment of a new reverse genetics system for respiratory syncytial virus under the control of RNA polymerase II. Microbiol Immunol. 2023 Sep;67(9):413-421. doi:10.1111/1348-0421.13088. Epub 2023 Jul 9. PMID: 37424190.

3. Sugimoto S, Kakizaki M, Kawase M, Kawachi K, Ujike M, Kamitani W, Sentsui H,Shirato K. Single Amino Acid Substitution in the Receptor Binding Domain ofSpike Protein Is Sufficient To Convert the Neutralization Profile betweenEthiopian and Middle Eastern Isolates of Middle East Respiratory Coronavirus.Microbiol Spectr. 2023 Feb 6;11(2):e0459022. doi: 10.1128/spectrum.04590-22.Epub ahead of print. PMID: 36744940; PMCID: PMC10100835.

4. Otsubo R, Minamitani T, Kobiyama K, Fujita J, Ito T, Ueno S, Anzai I, TaninoH, Aoyama H, Matsuura Y, Namba K, Imadome KI, Ishii KJ, Tsumoto K, Kamitani W,Yasui T. Human antibody recognition and neutralization mode on the NTD and RBDdomains of SARS-CoV-2 spike protein. Sci Rep. 2022 Nov 22;12(1):20120. doi:10.1038/s41598-022-24730-4. PMID: 36418391; PMCID: PMC9684487.

5.  Yoshida A, Okamura S, Torii S, Komatsu S, Miyazato P, Sasaki H, Ueno S,Suzuki H, Kamitani W, Ono C, Matsuura Y, Takekawa S, Yamanishi K, Ebina H.Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variantsinduces protective immunity. iScience. 2022 Nov 18;25(11):105412. doi:10.1016/j.isci.2022.105412. Epub 2022 Oct 20. PMID: 36320329; PMCID: PMC9614708.

6. Hirakawa H, Suzue K, Uchida M, Takita A, Kamitani W, Tomita H. A MacroporousMagnesium Oxide-Templated Carbon Adsorbs Shiga Toxins and Type III SecretoryProteins in Enterohemorrhagic <i>Escherichia coli</i>, Which AttenuatesVirulence. Front Microbiol. 2022 May 6;13:883689. doi:10.3389/fmicb.2022.883689. PMID: 35602086; PMCID: PMC9120352.

7.  Ujike M, Etoh Y, Urushiyama N, Taguchi F, Asanuma H, Enjuanes L, Kamitani W.Reverse Genetics with a Full-Length Infectious cDNA Clone of Bovine Torovirus. JVirol. 2022 Feb 9;96(3):e0156121. doi: 10.1128/JVI.01561-21. Epub 2021 Nov 24.PMID: 34817201; PMCID: PMC8827028.

8. Yamaguchi T, Hoshizaki M, Minato T, Nirasawa S, Asaka MN, Niiyama M, Imai M,Uda A, Chan JF, Takahashi S, An J, Saku A, Nukiwa R, Utsumi D, Kiso M, YasuharaA, Poon VK, Chan CC, Fujino Y, Motoyama S, Nagata S, Penninger JM, Kamada H,Yuen KY, Kamitani W, Maeda K, Kawaoka Y, Yasutomi Y, Imai Y, Kuba K. ACE2-likecarboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury. NatCommun. 2021 Nov 23;12(1):6791. doi: 10.1038/s41467-021-27097-8. PMID: 34815389;PMCID: PMC8610983.

9. Urano E, Okamura T, Ono C, Ueno S, Nagata S, Kamada H, Higuchi M, Furukawa M,Kamitani W, Matsuura Y, Kawaoka Y, Yasutomi Y. COVID-19 cynomolgus macaque modelreflecting human COVID-19 pathological conditions. Proc Natl Acad Sci U S A.2021 Oct 26;118(43):e2104847118. doi: 10.1073/pnas.2104847118. PMID: 34625475;PMCID: PMC8639365.

10. Konno S, Kobayashi K, Senda M, Funai Y, Seki Y, Tamai I, Schäkel L, Sakata K,Pillaiyar T, Taguchi A, Taniguchi A, Gütschow M, Müller CE, Takeuchi K, HirohamaM, Kawaguchi A, Kojima M, Senda T, Shirasaka Y, Kamitani W, Hayashi Y. 3CLProtease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2Agents. J Med Chem. 2022 Feb 24;65(4):2926-2939. doi:10.1021/acs.jmedchem.1c00665. Epub 2021 Jul 27. PMID: 34313428; PMCID:PMC8340582.

11. Taniguchi M, Minami S, Ono C, Hamajima R, Morimura A, Hamaguchi S, Akeda Y,Kanai Y, Kobayashi T, Kamitani W, Terada Y, Suzuki K, Hatori N, Yamagishi Y,Washizu N, Takei H, Sakamoto O, Naono N, Tatematsu K, Washio T, Matsuura Y,Tomono K. Combining machine learning and nanopore construction creates anartificial intelligence nanopore for coronavirus detection. Nat Commun. 2021 Jun17;12(1):3726. doi: 10.1038/s41467-021-24001-2. PMID: 34140500; PMCID:PMC8211865.

12.  Hirakawa H, Takita A, Uchida M, Kaneko Y, Kakishima Y, Tanimoto K, Kamitani W, Tomita H. Adsorption of Phenazines Produced by <i>Pseudomonas aeruginosa</i>Using AST-120 Decreases Pyocyanin-Associated Cytotoxicity. Antibiotics (Basel).2021 Apr 13;10(4):434. doi: 10.3390/antibiotics10040434. PMID: 33924459; PMCID:PMC8068879.

13. Torii S, Ono C, Suzuki R, Morioka Y, Anzai I, Fauzyah Y, Maeda Y, Kamitani W, Fukuhara T, Matsuura Y. Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction. Cell Rep. 2021 Apr20;35(3):109014. doi: 10.1016/j.celrep.2021.109014. Epub 2021 Apr 1. PMID:33838744; PMCID: PMC8015404.

14.  Hirakawa H, Suzue K, Takita A, Kamitani W, Tomita H. Roles of OmpX, an OuterMembrane Protein, on Virulence and Flagellar Expression in UropathogenicEscherichia coli. Infect Immun. 2021 May 17;89(6):e00721-20. doi:10.1128/IAI.00721-20. PMID: 33753414; PMCID: PMC8316124.

15.  Ngo-Thanh H, Thuy TD, Suzue K, Kamitani W, Yokoo H, Isoda K, Shimokawa C,Hisaeda H, Imai T. Long-term acrylamide exposure exacerbates brain and lungpathology in a mouse malaria model. Food Chem Toxicol. 2021 May;151:112132. doi:10.1016/j.fct.2021.112132. Epub 2021 Mar 15. PMID: 33737113.

16. Ujike M, Kawachi Y, Matsunaga Y, Etho Y, Asanuma H, Kamitani W, Taguchi F.Characterization of Localization and Export Signals of Bovine TorovirusNucleocapsid Protein Responsible for Extensive Nuclear and NucleolarAccumulation and Their Importance for Virus Growth. J Virol. 2021 Jan13;95(3):e02111-20. doi: 10.1128/JVI.02111-20. PMID: 33177195; PMCID:PMC7925113.

17. Kubota-Koketsu R, Terada Y, Yunoki M, Sasaki T, Nakayama EE, Kamitani W,Shioda T. Neutralizing and binding activities against SARS-CoV-1/2, MERS-CoV,and human coronaviruses 229E and OC43 by normal human intravenous immunoglobulinderived from healthy donors in Japan. Transfusion. 2021 Feb;61(2):356-360. doi:10.1111/trf.16161. Epub 2020 Oct 26. PMID: 33104267.

18.  Matsuyama S, Kawase M, Nao N, Shirato K, Ujike M, Kamitani W, Shimojima M,Fukushi S. The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication byTargeting the Viral Replication-Transcription Complex in Cultured Cells. JVirol. 2020 Dec 9;95(1):e01648-20. doi: 10.1128/JVI.01648-20. PMID: 33055254;PMCID: PMC7737752.

19. Ngo-Thanh H, Sasaki T, Suzue K, Yokoo H, Isoda K, Kamitani W, Shimokawa C,Hisaeda H, Imai T. Blood-cerebrospinal fluid barrier: another site disruptedduring experimental cerebral malaria caused by Plasmodium berghei ANKA. Int JParasitol. 2020 Dec;50(14):1167-1175. doi: 10.1016/j.ijpara.2020.07.007. Epub2020 Sep 1. PMID: 32882285.

20. Kimura H, Kurusu H, Sada M, Kurai D, Murakami K, Kamitani W, Tomita H,Katayama K, Ryo A. Molecular pharmacology of ciclesonide against SARS-CoV-2. JAllergy Clin Immunol. 2020 Aug;146(2):330-331. doi: 10.1016/j.jaci.2020.05.029.Epub 2020 Jun 13. PMID: 32593491; PMCID: PMC7293530.

21. Kamitani W. [Basic information of Coronavirus]. Uirusu. 2020;70(1):29-36.Japanese. doi: 10.2222/jsv.70.29. PMID: 33967109.

22. Terada Y, Kuroda Y, Morikawa S, Matsuura Y, Maeda K, Kamitani W.Establishment of a Virulent Full-Length cDNA Clone for Type I Feline CoronavirusStrain C3663. J Virol. 2019 Oct 15;93(21):e01208-19. doi: 10.1128/JVI.01208-19.PMID: 31375588; PMCID: PMC6803248.

23. Shirato K, Melaku SK, Kawachi K, Nao N, Iwata-Yoshikawa N, Kawase M,Kamitani W, Matsuyama S, Tessema TS, Sentsui H. Middle East Respiratory SyndromeCoronavirus in Dromedaries in Ethiopia Is Antigenically Different From theMiddle East Isolate EMC. Front Microbiol. 2019 Jun 19;10:1326. doi:10.3389/fmicb.2019.01326. PMID: 31275264; PMCID: PMC6593072.

24. Suzuki T, Terada Y, Enjuanes L, Ohashi S, Kamitani W. S1 Subunit of SpikeProtein from a Current Highly Virulent Porcine Epidemic Diarrhea Virus Is anImportant Determinant of Virulence in Piglets. Viruses. 2018 Aug 30;10(9):467.doi: 10.3390/v10090467. PMID: 30200258; PMCID: PMC6163780.

25. Matsuyama S, Shirato K, Kawase M, Terada Y, Kawachi K, Fukushi S, Kamitani W. Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not ActivatedDirectly by Cellular Furin during Viral Entry into Target Cells. J Virol. 2018Sep 12;92(19):e00683-18. doi: 10.1128/JVI.00683-18. PMID: 30021905; PMCID:PMC6146822.

26. Shirato K, Semba S, El-Kafrawy SA, Hassan AM, Tolah AM, Takayama I, KageyamaT, Notomi T, Kamitani W, Matsuyama S, Azhar EI. Development of fluorescentreverse transcription loop-mediated isothermal amplification (RT-LAMP) usingquenching probes for the detection of the Middle East respiratory syndromecoronavirus. J Virol Methods. 2018 Aug;258:41-48. doi:10.1016/j.jviromet.2018.05.006. Epub 2018 May 12. PMID: 29763640; PMCID:PMC7113683.

27. Muto M, Kamitani W, Sakai M, Hirano M, Kobayashi S, Kariwa H, Yoshii K.Identification and analysis of host proteins that interact with the3'-untranslated region of tick-borne encephalitis virus genomic RNA. Virus Res.2018 Apr 2;249:52-56. doi: 10.1016/j.virusres.2018.03.006. Epub 2018 Mar 12.PMID: 29545014.

28. Phanthanawiboon S, Pambudi S, Omokoko MD, Hanabara K, A-Nuegoonpipat A,Kamitani W, Ikuta K, Kurosu T. Construction of a high-yield dengue virus byreplacing nonstructural proteins 3-4B without increasing virulence. BiochemBiophys Res Commun. 2018 Jan 1;495(1):1221-1226. doi:10.1016/j.bbrc.2017.11.137. Epub 2017 Nov 22. PMID: 29175328.

29. Chen M, Aoki-Utsubo C, Kameoka M, Deng L, Terada Y, Kamitani W, Sato K,Koyanagi Y, Hijikata M, Shindo K, Noda T, Kohara M, Hotta H. Broad-spectrumantiviral agents: secreted phospholipase A₂ targets viral envelopelipid bilayers derived from the endoplasmic reticulum membrane. Sci Rep. 2017Nov 21;7(1):15931. doi: 10.1038/s41598-017-16130-w. PMID: 29162867; PMCID:PMC5698466.

30. Terada Y, Kawachi K, Matsuura Y, Kamitani W. MERS coronavirus nsp1participates in an efficient propagation through a specific interaction withviral RNA. Virology. 2017 Nov;511:95-105. doi: 10.1016/j.virol.2017.08.026. Epub2017 Aug 23. PMID: 28843094; PMCID: PMC7118922.

31. Sakai Y, Kawachi K, Terada Y, Omori H, Matsuura Y, Kamitani W. Two-aminoacids change in the nsp4 of SARS coronavirus abolishes viral replication.Virology. 2017 Oct;510:165-174. doi: 10.1016/j.virol.2017.07.019. Epub 2017 Jul21. PMID: 28738245; PMCID: PMC7111695.

32. Yumiketa Y, Narita T, Inoue Y, Sato G, Kamitani W, Oka T, Katayama K,Sakaguchi T, Tohya Y. Nonstructural protein p39 of feline calicivirus suppresseshost innate immune response by preventing IRF-3 activation. Vet Microbiol. 2016Mar 15;185:62-7. doi: 10.1016/j.vetmic.2016.02.005. Epub 2016 Feb 10. PMID:26931393.

33. Katoh H, Okamoto T, Fukuhara T, Kambara H, Morita E, Mori Y, Kamitani W,Matsuura Y. Japanese encephalitis virus core protein inhibits stress granuleformation through an interaction with Caprin-1 and facilitates viralpropagation. J Virol. 2013 Jan;87(1):489-502. doi: 10.1128/JVI.02186-12. Epub2012 Oct 24. PMID: 23097442; PMCID: PMC3536427.

34. Tanaka T, Kamitani W, DeDiego ML, Enjuanes L, Matsuura Y. Severe acuterespiratory syndrome coronavirus nsp1 facilitates efficient propagation in cellsthrough a specific translational shutoff of host mRNA. J Virol. 2012Oct;86(20):11128-37. doi: 10.1128/JVI.01700-12. Epub 2012 Aug 1. PMID: 22855488;PMCID: PMC3457165.

35. Kambara H, Fukuhara T, Shiokawa M, Ono C, Ohara Y, Kamitani W, Matsuura Y.Establishment of a novel permissive cell line for the propagation of hepatitis Cvirus by expression of microRNA miR122. J Virol. 2012 Feb;86(3):1382-93. doi:10.1128/JVI.06242-11. Epub 2011 Nov 23. PMID: 22114337; PMCID: PMC3264374.

36. Katoh H, Mori Y, Kambara H, Abe T, Fukuhara T, Morita E, Moriishi K,Kamitani W, Matsuura Y. Heterogeneous nuclear ribonucleoprotein A2 participatesin the replication of Japanese encephalitis virus through an interaction withviral proteins and RNA. J Virol. 2011 Nov;85(21):10976-88. doi:10.1128/JVI.00846-11. Epub 2011 Aug 24. PMID: 21865391; PMCID: PMC3194950.

37. Kamitani W, Huang C, Narayanan K, Lokugamage KG, Makino S. A two-prongedstrategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein.Nat Struct Mol Biol. 2009 Nov;16(11):1134-40. doi: 10.1038/nsmb.1680. Epub 2009Oct 18. PMID: 19838190; PMCID: PMC2784181.

38. Ikegami T, Narayanan K, Won S, Kamitani W, Peters CJ, Makino S. Dualfunctions of Rift Valley fever virus NSs protein: inhibition of host mRNAtranscription and post-transcriptional downregulation of protein kinase PKR. AnnN Y Acad Sci. 2009 Sep;1171 Suppl 1(Suppl 1):E75-85. doi:10.1111/j.1749-6632.2009.05054.x. PMID: 19751406; PMCID: PMC3137120.

39. Tohya Y, Narayanan K, Kamitani W, Huang C, Lokugamage K, Makino S.Suppression of host gene expression by nsp1 proteins of group 2 batcoronaviruses. J Virol. 2009 May;83(10):5282-8. doi: 10.1128/JVI.02485-08. Epub2009 Mar 4. PMID: 19264783; PMCID: PMC2682096.

40. Ikegami T, Narayanan K, Won S, Kamitani W, Peters CJ, Makino S. Rift Valleyfever virus NSs protein promotes post-transcriptional downregulation of proteinkinase PKR and inhibits eIF2alpha phosphorylation. PLoS Pathog. 2009Feb;5(2):e1000287. doi: 10.1371/journal.ppat.1000287. Epub 2009 Feb 6. PMID:19197350; PMCID: PMC2629125.

41. Narayanan K, Huang C, Lokugamage K, Kamitani W, Ikegami T, Tseng CT, MakinoS. Severe acute respiratory syndrome coronavirus nsp1 suppresses host geneexpression, including that of type I interferon, in infected cells. J Virol.2008 May;82(9):4471-9. doi: 10.1128/JVI.02472-07. Epub 2008 Feb 27. PMID:18305050; PMCID: PMC2293030.

42. Ohtaki N, Kamitani W, Watanabe Y, Hayashi Y, Yanai H, Ikuta K, Tomonaga K.Downregulation of an astrocyte-derived inflammatory protein, S100B, reducesvascular inflammatory responses in brains persistently infected with Bornadisease virus. J Virol. 2007 Jun;81(11):5940-8. doi: 10.1128/JVI.02137-06. Epub2007 Mar 21. PMID: 17376896; PMCID: PMC1900267.

43. Watanabe Y, Ibrahim MS, Hagiwara K, Okamoto M, Kamitani W, Yanai H, OhtakiN, Hayashi Y, Taniyama H, Ikuta K, Tomonaga K. Characterization of a Bornadisease virus field isolate which shows efficient viral propagation andtransmissibility. Microbes Infect. 2007 Apr;9(4):417-27. doi:10.1016/j.micinf.2006.12.015. Epub 2007 Jan 12. PMID: 17306587.

44. Kamitani W, Narayanan K, Huang C, Lokugamage K, Ikegami T, Ito N, Kubo H,Makino S. Severe acute respiratory syndrome coronavirus nsp1 protein suppresseshost gene expression by promoting host mRNA degradation. Proc Natl Acad Sci U SA. 2006 Aug 22;103(34):12885-90. doi: 10.1073/pnas.0603144103. Epub 2006 Aug 15.PMID: 16912115; PMCID: PMC1568942.

45. Yamashita M, Kamitani W, Yanai H, Ohtaki N, Watanabe Y, Lee BJ, Tsuji S,Ikuta K, Tomonaga K. Persistent borna disease virus infection confersinstability of HSP70 mRNA in glial cells during heat stress. J Virol. 2005Feb;79(4):2033-41. doi: 10.1128/JVI.79.4.2033-2041.2005. PMID: 15681405; PMCID:PMC546570.

46. Lee BJ, Watanabe M, Kamitani W, Baba S, Yamashita M, Kobayashi T, TomonagaK, Ikuta K. Age- and host-dependent control of Borna disease virus spread in thedeveloping brains of gerbils and rats. Microbes Infect. 2003 Nov;5(13):1195-204.doi: 10.1016/j.micinf.2003.07.007. PMID: 14623015.

47. Zhang G, Kobayashi T, Kamitani W, Komoto S, Yamashita M, Baba S, Yanai H,Ikuta K, Tomonaga K. Borna disease virus phosphoprotein represses p53-mediatedtranscriptional activity by interference with HMGB1. J Virol. 2003Nov;77(22):12243-51. doi: 10.1128/jvi.77.22.12243-12251.2003. PMID: 14581561;PMCID: PMC254253.

48. Okamoto M, Hagiwara K, Kamitani W, Sako T, Hirayama K, Kirisawa R, Tsuji M,Ishihara C, Iwai H, Kobayashi T, Tomonaga K, Ikuta K, Taniyama H. Experimentalvertical transmission of Borna disease virus in the mouse. Arch Virol. 2003Aug;148(8):1557-68. doi: 10.1007/s00705-003-0120-y. PMID: 12898331.

49. Kamitani W, Ono E, Yoshino S, Kobayashi T, Taharaguchi S, Lee BJ, YamashitaM, Kobayashi T, Okamoto M, Taniyama H, Tomonaga K, Ikuta K. Glial expression ofBorna disease virus phosphoprotein induces behavioral and neurologicalabnormalities in transgenic mice. Proc Natl Acad Sci U S A. 2003 Jul22;100(15):8969-74. doi: 10.1073/pnas.1531155100. Epub 2003 Jul 11. PMID:12857949; PMCID: PMC166422.

50. Kobayashi T, Zhang G, Lee BJ, Baba S, Yamashita M, Kamitani W, Yanai H,Tomonaga K, Ikuta K. Modulation of Borna disease virus phosphoprotein nuclearlocalization by the viral protein X encoded in the overlapping open readingframe. J Virol. 2003 Jul;77(14):8099-107. doi: 10.1128/jvi.77.14.8099-8107.2003.PMID: 12829848; PMCID: PMC161951.

51. Watanabe M, Lee BJ, Yamashita M, Kamitani W, Kobayashi T, Tomonaga K, IkutaK. Borna disease virus induces acute fatal neurological disorders in neonatalgerbils without virus- and immune-mediated cell destructions. Virology. 2003 Jun5;310(2):245-53. doi: 10.1016/s0042-6822(03)00158-2. PMID: 12781712.

52. Kamitani W, Tomonaga K, Ikuta K. [Borna disease virus infection]. NihonRinsho. 2003 Feb;61 Suppl 2:128-34. Japanese. PMID: 12722201.

53. Okamoto M, Kagawa Y, Kamitani W, Hagiwara K, Kirisawa R, Iwai H, Ikuta K,Taniyama H. Borna disease in a dog in Japan. J Comp Pathol. 2002May;126(4):312-7. doi: 10.1053/jcpa.2002.0550. PMID: 12056780.

54. Ibrahim MS, Watanabe M, Palacios JA, Kamitani W, Komoto S, Kobayashi T,Tomonaga K, Ikuta K. Varied persistent life cycles of Borna disease virus in ahuman oligodendroglioma cell line. J Virol. 2002 Apr;76(8):3873-80. doi:10.1128/jvi.76.8.3873-3880.2002. PMID: 11907227; PMCID: PMC136060.

55. Okamoto M, Furuoka H, Hagiwara K, Kamitani W, Kirisawa R, Ikuta K, TaniyamaH. Borna disease in a heifer in Japan. Vet Rec. 2002 Jan 5;150(1):16-8. doi:10.1136/vr.150.1.16. PMID: 11817858.

56. Hagiwara K, Okamoto M, Kamitani W, Takamura S, Taniyama H, Tsunoda N, TanakaH, Iwai H, Ikuta K. Nosological study of Borna disease virus infection in racehorses. Vet Microbiol. 2002 Feb 4;84(4):367-74. doi:10.1016/s0378-1135(01)00446-1. PMID: 11750144.

57. Kamitani W, Shoya Y, Kobayashi T, Watanabe M, Lee BJ, Zhang G, Tomonaga K,Ikuta K. Borna disease virus phosphoprotein binds a neurite outgrowth factor,amphoterin/HMG-1. J Virol. 2001 Sep;75(18):8742-51. doi:10.1128/jvi.75.18.8742-8751.2001. PMID: 11507219; PMCID: PMC115119.

58. Taniyama H, Okamoto M, Hirayama K, Hagiwara K, Kirisawa R, Kamitani W,Tsunoda N, Ikuta K. Equine Borna disease in Japan. Vet Rec. 2001 Apr14;148(15):480-2. doi: 10.1136/vr.148.15.480. PMID: 11334075.

59. Watanabe M, Lee BJ, Kamitani W, Kobayashi T, Taniyama H, Tomonaga K, IkutaK. Neurological diseases and viral dynamics in the brains of neonatally bornadisease virus-infected gerbils. Virology. 2001 Mar 30;282(1):65-76. doi:10.1006/viro.2001.0813. PMID: 11259191.

60. Kobayashi T, Kamitani W, Zhang G, Watanabe M, Tomonaga K, Ikuta K. Bornadisease virus nucleoprotein requires both nuclear localization and exportactivities for viral nucleocytoplasmic shuttling. J Virol. 2001Apr;75(7):3404-12. doi: 10.1128/JVI.75.7.3404-3412.2001. PMID: 11238866; PMCID:PMC114133.

61. Watanabe M, Zhong Q, Kobayashi T, Kamitani W, Tomonaga K, Ikuta K. Molecularratio between borna disease viral-p40 and -p24 proteins in infected cellsdetermined by quantitative antigen capture ELISA. Microbiol Immunol.2000;44(9):765-72. doi: 10.1111/j.1348-0421.2000.tb02561.x. PMID: 11092240.

62. Kobayashi T, Watanabe M, Kamitani W, Tomonaga K, Ikuta K. Translationinitiation of a bicistronic mRNA of Borna disease virus: a 16-kDa phosphoproteinis initiated at an internal start codon. Virology. 2000 Nov 25;277(2):296-305.doi: 10.1006/viro.2000.0592. PMID: 11080477.

63. Tomonaga K, Kobayashi T, Lee BJ, Watanabe M, Kamitani W, Ikuta K.Identification of alternative splicing and negative splicing activity of anonsegmented negative-strand RNA virus, Borna disease virus. Proc Natl Acad SciU S A. 2000 Nov 7;97(23):12788-93. doi: 10.1073/pnas.97.23.12788. PMID:11070091; PMCID: PMC18842.

64. Hagiwara K, Kamitani W, Takamura S, Taniyama H, Nakaya T, Tanaka H, KirisawaR, Iwai H, Ikuta K. Detection of Borna disease virus in a pregnant mare and herfetus. Vet Microbiol. 2000 Mar 15;72(3-4):207-16. doi:10.1016/s0378-1135(99)00206-0. PMID: 10727831.

65. Nakamura Y, Watanabe M, Kamitani W, Taniyama H, Nakaya T, Nishimura Y,Tsujimoto H, Machida S, Ikuta K. High prevalence of Borna disease virus indomestic cats with neurological disorders in Japan. Vet Microbiol. 1999Dec;70(3-4):153-69. doi: 10.1016/s0378-1135(99)00135-2. PMID: 10596800.

業績一覧　寄生虫学免疫学研究