TMS-RECOM project aims at enhancing our comprehension of brain reorganization and compensatory processes following the neuromodulation of a node within a brain network.
Brain reorganization refers to the changes that occur at the neural level when a brain region is targeted with transcranial magnetic stimulation (TMS). Such neural reorganization is reflected in changes in activation or functional connectivity not only at or near the stimulated area but also within and between brain networks. These TMS-induced network changes may reflect compensatory processes triggered to adapt to the system disruption. As such, they could be functionally relevant in explaining TMS effects on behavior or cognition. Both brain reorganization and compensation can be explained by the functional and structural connectivity between regions, although the extent of the contribution of each type of node communication is still unclear. Baseline functional connectivity and structural connections properties exhibit significant personal differences. Hence, we anticipate substantial variability among individuals in the neural response to TMS and its impact on behavior.Â