蛋白質折疊與疾病

•   授課教師：吳雨珊 / yushanwu@thu.edu.tw 

• 課程目標及內涵 (Course Objectives and Contents)

This course aims to broaden the knowledge of protein folding/misfolding and to relate it to the human diseases. 

主要參考書籍/資料 (Textbooks and References)

1. Ken A. Dill and Justin L. MacCallum, The Protein-Folding Problem, 50 Years On. Science, 2012, p1042-1046.

2. F. Ulrich Hartl, Molecular Chaperons in Cellular Protein Folding, Nature, 1996, v.381, p571-580.

3. “The importance of protein folding” by Joachim Pietzsch

4. F. Ulrich Hartl, Protein Misfolding Diseases, Annu. Rev. Biochem. 2017, V.86, p21–26.

5. Fabrizio Chiti and Christopher M. Dobson, Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade, Annu. Rev. Biochem. 2017, V.86, p27–68.

6. Surabhi Mehra, Shruti Sahay and Samir K. Maji, BBA - Proteins and Proteomics,

https://doi.org/10.1016/j.bbapap.2019.03.001

7. Whitechurch B.C., Welton J.M., Collins S.J., Lawson V.A. (2017) Prion Diseases. In: Beart P., Robinson M., Rattray M., Maragakis N. (eds) Neurodegenerative Diseases. Advances in Neurobiology, vol 15. Springer, Cham

8. “ Treating protein folding diseases” by Sophie Petit-Zeman