有機合成

• 授課教師：林振東 / ctlin@thu.edu.tw 

• 課程目標及內涵 

引導學生從記憶學習轉向概念學習，使學生瞭解化合物之化學變化，並且能正確使用試劑與綜合運用官能基的轉換而完成目標產物的製備，以達成培育具備有機化合物合成能力的學者，主要目標為:

1.培養學生認識有機試劑的功能及用途。

2.培養學生有機官能基的製備與化學轉換。

3.培養學生設計化合物的全合成與使用有效試劑。

4.培養學生瞭解化學反應的轉變過程。

5.培養學生認識有機合成在產業的利用。為達成培育具備有機化合物合成能力的學者，本課程內容規畫由淺而深，循序漸進介紹有機官能基的轉變，及延伸至藥物的全合成。過程中將引入試劑的安全使用與化學反應機構，講解化學變化的詳細步驟以增進學習成效。授課內涵分為還原反應、氧化反應、鹵化反應、碳-碳鍵的形成、化學人名反應、天然物的全合成與逆逕分析等六大主題。教材除引用Carruthers的教科書外，另採用化學文獻期刊，自編教材等介紹產業研發及尖端研究發展。

• 授課教師：林振東 / ctlin@thu.edu.tw 

• Course Objectives and Contents

To guide students from memory learning to concept learning, so that students can understand the chemical changes of compounds, and can correctly use reagents and comprehensively use the conversion of functional groups to complete the preparation of target products, so as to achieve the goal of cultivating scholars with the ability to synthesize organic compounds. The main goal is to:

1. Cultivate students' understanding of the functions and uses of organic reagents.

2. Cultivate the preparation and chemical conversion of organic functional groups for students.

3. Train students to design the total synthesis of compounds and use effective reagents.

4. Cultivate students' understanding of the transformation process of chemical reactions.

5. Cultivate students' understanding of the utilization of organic synthesis in the industry. In order to cultivate scholars with the ability to synthesize organic compounds, the content of this course is planned from shallow to deep, introducing the transformation of organic functional groups step by step, and extending to the total synthesis of drugs. The safe use of reagents and chemical reaction mechanisms will be introduced during the process, and detailed steps of chemical changes will be explained to enhance learning effectiveness. The teaching content is divided into six main themes: reduction reactions, oxidation reactions, halogenation reactions, formation of carbon carbon bonds, chemical reactions, total synthesis and reverse analysis of natural substances. In addition to citing Carruthers' textbooks, the textbooks also use chemical literature journals, self compiled textbooks, and other materials to introduce industrial research and cutting-edge research development.

主要參考書籍/資料 (Textbooks and References)

1.自備講義

2.Moden Methods of Organic Synthesis, W. Carruthers and I. Coldham, 4th ed. 2004, Cambridge.

3. R. K. Mackie, D.M. Smith, R. A. Aitken; Guidebook to Organic Synthesis, 3rd ed. 1999, Pearson Education Ltd, England.

4. T. Laue, A. Plagens; Named Organic Reactions, 2005, Wiley, England.

5.化學期刊.