不對稱合成

•  授課教師：蔡政哲 / chengchetsai@thu.edu.tw 

• 課程目標及內涵 

不對稱合成是指使用有機合成方式製備具有掌性(光學活性)的有機化合物，目前此類研究已經被廣泛應用於天然物與藥物合成中。不對稱合成策略分為四大類: (1) 修飾具有光學活性的天然物。(2) 分離外消旋混合物。(3) 使用掌性輔助基團或試劑建立掌性中心。(4) 使用掌性催化劑建立掌性中心。本課程教學重點分為三部分:(1) 根據所需要的掌性化合物的結構特性，設計快速及有效的合成策略。(2) 使用不同的分析儀器鑑定掌性化合物的光學純度、絕對立體組態、相對立體組態。(3) 探討文獻上具有代表性的不對稱合成方法以及其方法於天然物與藥物合成中的實際應用。  

• 授課教師：蔡政哲 / chengchetsai@thu.edu.tw 

• Course Objectives and Contents

Asymmetric synthesis refers to the use of organic synthesis to prepare chiral (optical active) organic compounds. At present, this type of research has been widely used in the synthesis of natural products and drugs. Asymmetric synthetic strategies fall into four categories: (1) Modification of optically active natural products. (2) Separation of the racemic mixture. (3) Use chiral auxiliary groups or reagents to create chiral centers. (4) Establishment of chiral centers using chiral catalysts. The teaching focus of this course is divided into three parts: (1) According to the structural characteristics of the desired chiral compound, design a fast and effective synthesis strategy. (2) Use different analytical instruments to identify the optical purity, absolute stereo configuration, and relative stereo configuration of chiral compounds. (3) Discuss the representative asymmetric synthesis methods in the literature and their practical application in the synthesis of natural products and drugs.

主要參考書籍/資料 (Textbooks and References)

1. Asymmetric Synthesis (Mathias Christmann and Stefan Bräse), 2012.

2. Asymmetric Synthesis of Natural Products (Ari M. P. Koskinen), 2012.

3. Catalytic Asymmetric Synthesis (Iwao Ojima), 2010.