Dr. Joseph Loscalzo

Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

Dr. Joseph Loscalzo is Hersey Professor of the Theory and Practice of Medicine, and Soma Weiss, M.D., Distinguished Chair in Medicine at Harvard Medical School, Chairman of the Department of Medicine, and Physician-in-Chief at Brigham and Women’s Hospital. Dr. Loscalzo received his A.B. degree, summa cum laude, his Ph.D. in biochemistry, and his M.D. from the University of Pennsylvania. His clinical training was completed at Brigham and Women’s Hospital and Harvard Medical School, where he served as Resident and Chief Resident in medicine and Fellow in cardiovascular medicine.

After completing his training, Dr. Loscalzo joined the Harvard faculty and staff at Brigham and Women’s Hospital in 1984. He rose to the rank of Associate Professor of Medicine, Chief of Cardiology at the West Roxbury Veterans Administration Medical Center, and Director of the Center for Research in Thrombolysis at Brigham and Women’s Hospital. He joined the faculty of Boston University in 1994, first as Chief of Cardiology and, in 1997, Wade Professor and Chair of Medicine, Professor of Biochemistry, and Director of the Whitaker Cardiovascular Institute. He returned to Harvard and Brigham and Women’s Hospital in 2005.

Dr. Loscalzo is recognized as an outstanding cardiovascular scientist, clinician, and teacher. He has received many awards, including the Clinician-Scientist Award, the Distinguished Scientist Award, the Research Achievement Award, and the Paul Dudley White Award from the American Heart Association; a Research Career Development Award, a Specialized Center of Research in Ischemic Heart Disease Award, and a MERIT Award from the National Institutes of Health; the George W. Thorn Award for Excellence in Teaching at Brigham and Women’s Hospital, the Educator of the Year Award in Clinical Medicine from Boston University, and the William Silen Lifetime Achievement in Mentorship Award from Harvard Medical School; the Glaxo Cardiovascular Research Award, and the Outstanding Investigator Prize from the International Society for Heart Research; election to fellowship in the American Association for the Advancement of Science, and in the American Academy of Arts and Sciences; and election to the American Society for Clinical Investigation, the Association of American Physicians, and the National Academy of Medicine. Castle Connolly has named him one of America’s Top Doctors. He served as an associate editor of the New England Journal of Medicine for nine years, Chair of the Cardiovascular Board of the American Board of Internal Medicine, Chair of the Research Committee of the American Heart Association, Chair of the Scientific Board of the Stanley J. Sarnoff Society of Fellows for Research in the Cardiovascular Sciences, and Chair of the Board of Scientific Counselors of the National Heart, Lung, and Blood Institute of the National Institutes of Health. He is a former member of the Advisory Council of the National Heart, Lung, and Blood Institute, and a former member of the Council of Councils of the National Institutes of Health. He is currently Director of the NIH-funded Center for Accelerated Innovation (the Boston Biomedical Innovation Center), the NIH-funded Harvard Undiagnosed Disease Network program. He is also former Editor-in-Chief of Circulation, currently Editor-at-Large of the New England Journal of Medicine, and a current senior editor of Harrison’s Principles of Internal Medicine.

Dr. Loscalzo has been a visiting professor at many institutions, holds two honorary degrees, has authored or co-authored over 1,000 scientific publications, has authored or edited 50 books, and holds 32 patents for his work in the field of nitric oxide and redox biology. He is also the recipient of many grants from the NIH and industry for his work in the areas of vascular biology, thrombosis, atherosclerosis, and, more recently, systems biology over the past thirty years. His most recent work has established the field of network medicine, a paradigm-changing discipline that seeks to re-define disease and therapeutics from an integrated perspective using systems biology and network science.

Areas of expertise/themes:

Network Medicine, Systems Biology, Metabolomics, Vascular Biology, Redox Biology

SESSION: Plenary Address

Day 2: September 12, 2019 | Plenary Address | 9:10 AM - 9:50 AM

Network Medicine: Approach to the Definition, Diagnosis and Treatment of Disease in the Era of Precision Medicine

Joseph Loscalzo, MD, PhD. Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

Since the 19th century, clinicians and biomedical researchers have used the Cartesian reductionist approach to study human biology, disease, and therapeutics. While the success of this strategy is indisputable, it has major shortcomings including most importantly oversimplification of complex biological phenomena. Until recently, the prospect of unravelling that complexity in a more integrative way has been limited by restricted data sets and inadequate analytical approaches. Biomedicine is now, however, poised to explore rigorously integrative system responses that govern pathophenotype. The rapid growth in large genomic data sets and detailed phenotyping coupled with the rapid expansion of quantitative approaches to their network-based analysis provide a unique opportunity by which to define the response of biological systems to normal, pathological, and therapeutic perturbations. Biomedical science is, therefore, now positioned to explore pathobiological complexity directly. This new field of network medicine, which applies systems biology and network science approaches to the dissection of molecular pathobiology and treatment, offers a truly novel path toward (re)defining and treating human disease in the modern era, and facilitates the trajectory of true precision medicine.

SESSION 1: SYSTEMS/NETWORK MEDICINE IN CLINICAL PRACTICE

Day 2: September 12, 2019 | Session 1 CO-CHAIR | 10:10 AM - NOON

Joseph Loscalzo, MD, PhD. Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

SESSION: CONCLUDING REMARKS

DAY 3: September 13, 2019 | 4:15 PM - 4:30 PM

Joseph Loscalzo, MD, PhD. Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.