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Wong, Chi-Huey 翁啟惠
Wong, Chi-Huey 翁啟惠
合聘特聘研究員 (與美國加州Scripps研究院合聘)
chwong@gate.sinica.edu.tw
02-27899929
EDUCATION AND POSITIONS HELD:
Ph.D. in Chemistry, MIT, 1979-1982
Postdoctoral Fellow, Harvard University, 1982–1983
Assistant Professor through Professor of Chemistry, Texas A&M University, 1983–1989
Professor and Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 1989–2006.
Member, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 1996–2006.
Head, Frontier Research Program on Glycotechnology, Institute of Physical and Chemical Research (RIKEN), Japan, 1991–1999.
Distinguished Professor, Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2003–present
Director, The Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2003–2006.
President, Academia Sinica, Taipei, Taiwan, 2006-2016.
Scripps Family Chair Professor, Department of Chemistry, The Scripps Research Institute, La Jolla, California, 2019-present
HONORS:
Searle Scholar Award in Biomedical Sciences, 1985
Presidential Young Investigator in Chemistry, 1986
The IUPAC International Carbohydrate Award, 1994
Elected Member of Academia Sinica, Taipei, 1994
Elected Member of the American Academy of Arts and Sciences, 1996
American Chemical Society Harrison Howe Award in Chemistry, 1998
American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry, 1999
The International Enzyme Engineering Award, 1999
Presidential Green Chemistry Award, USA, 2000
Elected Member of the National Academy of Sciences, USA 2002
American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 2005
The F. A. Cotton Medal for Excellence in Chemical Research, 2008
Editor-in-Chief, Bioorganic & Medicinal Chemistry, 1993–2010
Elected Associate Member of the European Molecular Biology Organization (EMBO), 2010
The American Chemical Society Arthur C. Cope Award, 2012
Nikkei Asia Prize for Science, Technology and Innovation, 2012
The Wolf Prize in Chemistry, 2014
Elected Fellow of the U.S. National Academy of Inventors, 2014
The Royal Society of Chemistry Robert Robinson Award, UK, 2015
Welch Award in Chemistry, 2021
Tetrahedron Prize for Creativity in Organic Chemistry, 2022
Barry Cohen International Award, Israel Chemical Society, 2023
FACS Foundation Lectureship, The Federation of Asian Chemical Societies, 2023
RESEARCH INTERESTS:
Chemical Biology and Drug Discovery
Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Current interest is centered on the development of discovery tools for understanding the role of biological glycosylation in cancer progression, bacterial and viral infection, neurodegenerative disorder and immune response. Programmable one-pot synthesis as well as chemo-enzymatic synthesis of oligosaccharides and homogeneous glycoproteins, and design of glycan microarrays and glycosylation probes are among the tools being developed for the study of cell-surface glycoconjugates. The ultimate goal of our research is to identify novel glycan targets for therapeutic development, including the AI-assisted development of carbohydrate-based vaccines, homogeneous antibodies with optimized effector functions, and inhibitors of key enzymes involved in the biosynthesis of glycan targets.
我們的研究工作主要著重於化學生物及新藥研發。從瞭解致病基因的功能及機制去設計並合成分子來進一步研究其與標的物的作用，進而研發出新的檢測方法及新 藥。目前重點放在瞭解醣分子在細胞表面所扮演的角色，醣蛋白合成方法的發展，醣晶片的設計與應用，及酵素抑制劑的設計與合成。希望將來能發展新的藥物以供 抗癌、抗病毒與抗細菌的研究。
SELECTED PUBLICATIONS:
H.-W. Huang, Y.-F. Zeng, V. S. Shivatare, T.-H. Tseng, C.-H. Wong, 2025, "Cell-based glycoengineering for production of homogeneous and specific glycoform enriched antibodies with improved effector functions", Proceedings of the National Academy of Sciences of the United States of America,122 (8), e2423853122. (SCIE)
R. Li, P. Chen, Y.-F. Zeng, T.-H. Tseng, V. Gannedi, L. Krasnova, C.-H. Wong, 2025, “Expedient Assembly of Multiantennary N-Glycans from Common N-Glycan Cores with Orthogonal Protection for the Profiling of Glycan-Binding Proteins.”, Journal of the American Chemical Society, 147(15), 12937-12948. (SCIE) (IF: 15; SCI ranking: 9.6%)
C.-C. Kung, J. Lo, K.-S. Liao, C.-Y. Wu, L.-C. Cheng, C. Chung, T.-L. Hsu, C. Ma, C.-H. Wong, 2025, “Expression of Human β3GalT5-1 in Insect Cells as Active Glycoforms for the Efficient Synthesis of Cancer-Associated Globo-Series Glycans”, Journal of the American Chemical Society, 147, 10864-10874. (SCIE) (IF: 15; SCI ranking: 9.6%)
J. Lo, C.-C. Kung, T.-J., C.-H. Wong, C. Ma, 2025, “Structure-Based Mechanism and Specificity of Human Galactosyltransferase β3GalT5”, Journal of the American Chemical Society, 147, 10875-10885. (SCIE) (IF: 15; SCI ranking: 9.6%)
N.-Y. Chen, C.-W. Lin, T.-Y. Lai, C.-Y. Wu, P.-C. Liao, T.-L. Hsu, C.-H. Wong, 2024, “Increased expression of SSEA-4 on TKI-resistant non-small cell lung cancer with EGFR-T790M mutation.”, Proceedings of the National Academy of Sciences of the United States of America, 121(5), e2313397121. (SCIE)
C.-Y. Fan, S.-W. Wang, C. Chung, J.-Y. Chen, C.-Y. Chang, Y.-C. Chen, T.-L. Hsu, T.-R. Cheng, C.-H. Wong, 2024, “Synthesis of a dendritic cell-targeted self-assembled polymeric nanoparticle for selective delivery of mRNA vaccines to elicit enhanced immune responses.”, Chemical science, 15(29), 11626-11632. (SCIE)
C.-W. Cheng, C.-Y. Wu, S.-W. Wang, J.-Y. Chen, C.-C. Kung, K.-S. Liao, C.-H. Wong, 2023, “Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA).”, Proceedings of the National Academy of Sciences of the United States of America, 120(49), e2314392120. (SCIE)
S.-W. Wang, Y.-A. Ko, C.-Y. Chen, K.-S. Liao, Y.-H. Chang, H.-Y. Lee, Y.-H. Yu, Y.-H. Lih, Y.-Y. Cheng, H.-H. Lin , T.-L. Hsu, C.-Y. Wu, K.-I. Lin, C.-H. Wong, 2023, “Mechanism of Antigen Presentation and Specificity of Antibody Cross-Reactivity Elicited by an Oligosaccharide-Conjugate Cancer Vaccine.”, Journal of the American Chemical Society, 145(17), 9840-9849. (SCIE)
V.-S. Shivatare , P.-K. Chuang , T.-H. Tseng , Y.-F. Zeng , H.-W. Huang , G. Veeranjaneyulu , H.-C. Wu , C.-H. Wong, 2023, “Study on antibody Fc-glycosylation for optimal effector functions.”, Chemical communications (Cambridge, England), 59, 5555-5558.
C.-Y. Wu, C.-W. Cheng, C.-C. Kung, K.-S. Liao, J.-T. Jan, C. Ma, C.-H. Wong, 2022, “Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine.”, Proceedings of the National Academy of Sciences of the United States of America, 119(9), e2119995119. (SCIE)
H.-Y. Huang, H.-Y. Liao, X. Chen, C.-W. Cheng, S.-W. Wang, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, H.-H. Ma, Y.-H. Chang, C.-Y. Tsai, P.-Y. Huang, S.-Y. Chang, T.-L. Chao, H.-C. Kao, Y.-M. Tsai, Y.-H. Chen, C.-Y. Chen, K.-C. Lee, C.-Y. Wu, J.-T. Jan, T.-J. R. Cheng, K.-I. Lin*, C. Ma, and C.-H. Wong, 2022, “Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models.”, Science translational medicine, 14(639), eabm0899. (SCIE)
H.-Y. Liao, S.-C. Wang, Y.-A. Koa, K.-I. Lin, C. Ma, T.-J. R. Cheng, and C.-H. Wong, 2020, “Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes”, Proceedings of the National Academy of Sciences, 117(30), 17757-17763.
W.-F. Wang, M.-Y. Jade Lu, T.-J. R. Cheng, Y.-C. Tang, Y.-C. Teng, T.-Y. Hwa, Y.-H. Chen, M.-Y. Li, M.-H. Wu, P.-C. Chuang, R. Jou, C.-H. Wong, and W.-H. Li, 2020, “Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome”, Genome Biology and Evolution, 12(2), 3890-3905. (SCIE)
L.-T. Chiu, N. Sabbavarapu, W.-C. Lin, C.-Y. Fang, C.-C. Wu, T.-J. Cheng, C.-H. Wong, S.-C. Hung, 2020, “Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1”, Journal of the American Chemical Society, 142(11), 5282-5292. (SCIE)
H.-J. Lo, L. Krasnova, S. Dey, T. Cheng, H. Liu, T.-I. Tsai, K. B. Wu, C.-Y. Wu, and C.-H. Wong, 2019, “Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing alpha2,6-Linked 3F(ax)-Neu5Ac.”, Journal of the American Chemical Society, 141(16), 6484-6488. (SCIE)
Y.-C. Tseng, C.-Y. Wu, M.-L. Liu, T.-H. Chen, W.-L. Chiang, Y.-H. Yu, J.-T. Jan, K.-I. Lin, C.-H. Wong and C. Ma, 2019, “Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections.”, Proceedings of the National Academy of Sciences of the United States of America, 116(10), 4200-4205. (SCIE)
P.-K. Chuang, M. Hsiao, T.-L. Hsu, C.-F. Chang, C.-Y. Wu, B.-R. Chen, H.-W. Huang, K.-S. Liao, C.-C. Chen, C.-L. Chen, S.-M. Yang, C. W. Kuo, P. Chen, P.-T. Chiu, I.-J. Chen, J.-S. Lai, C.-D. T. Yu, and C.-H. Wong, 2019, “Signaling pathway of globo-series glycosphingolipids and beta1,3-galactosyltransferase V (beta3GalT5) in breast cancer.”, Proceedings of the National Academy of Sciences of the United States of America, 116(9), 3518-3523. (SCIE)
W.-S. Wu, W.-C. Cheng, T.-R. Cheng, C.-H. Wong, 2018, “Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase.”, Journal of the American Chemical Society, 140(8), 2752-2755. (SCIE)
C.-W. Cheng, Y. Zhou, W.-H. Pan, S. Dey, C.-Y. Wu, W.-L. Hsu, and C.-H. Wong, 2018, “Hierarchical and programmable one-pot automated synthesis of oligosaccharides”, Nature Communications, 9, 5202. (SCIE)
P.-W. Lo, J.-J. Shie, C.-H. Chen, C.-Y. Wu, T.-L. Hsu, C.-H. Wong, 2018, “O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2”, Proceedings of the National Academy of Sciences of the United States of America, 115(28), 7302-7307. (SCIE)
Y.-W. Huang, H.-I. Yang, Y.-T. Wu, T.-L. Hsu, T.-W. Lin, J. Kelly, C.-H. Wong, 2017, “Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency”, Journal of the American Chemical Society, 139(37), 12947-12955. (SCIE)
T. H. Tseng, T.-W. Lin, C.-Y. Chen, C.-H. Chen, J.-L. Lin, T.-L. Hsu, C.-H. Wong, 2017, “Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases”, Journal of the American Chemical Society, 139(28), 9431-9434. (SCIE)
S. S. Shivatare, S.-H. Chang, T.-I. Tsai, S. Y. Tseng, Y.-S. Lin, Y.-Y. Cheng, C.-T. Ren, S. Pawar, C.-S. Tsai, H.-W. Shi, Y.-F. Zeng, C.-H. Liang, P. D. Kwong, D. R. Burton, C.-Y. Wu and C.-H. Wong, 2016, “Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies”, Nature Chemistry, 8(4), 338-346. (SCIE)
S. Danishefsky, Y.-K. Shue, M. Chang, C.-H. Wong, 2015, “Development of Globo-H Cancer Vaccine”, Accounts of Chemical Research, 48(3), 643-652. (SCIE)
J.-J. Shie, Y.-C. Liu, Y.−M. Lee, C. Lim, J.-M. Fang, C.-H. Wong, 2014, “An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation”, Journal of the American Chemical Society, 136(28), 9953-9961. (SCIE)
Y.-W. Lou, P.-Y. Wang, S.-C. Yeh, P.-K. Chuang, S.-T. Li, C.-Y. Wu, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2014, “Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers”, Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2482-2487. (SCIE)
J.-R. Chen, Y.-H. Yu, Y.-C. Tseng, W.-L. Chiang, M.-F. Chiang, Y.-A. Ko, Y.-K. Chiu, S.-H. Ma, C.-Y. Wu, J.-T. Jan, K.-I. Lin, C. Ma and C.-H. Wong, 2014, “Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections”, Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2476-2481. (SCIE)
Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu, C.-H. Wong, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2517-2522. (SCIE)
C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang, M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2013, “Fucosyltransferase 8 as a Functional Regulator of Non-Small Cell Lung Cancer”, Proceedings of the National Academy of Sciences of the United States of America, 110(2), 630-635. (SCIE)
C.-Y. Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H. Wong and C. Ma, 2012, “Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis”, Proceedings of the National Academy of Sciences of the United States of America, 109(17), 6496-6501. (SCIE)
Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, 2011, “Sialylation and Fucosylation of Epidermal Growth Factor Receptor Suppress its Dimerization and Activation in Lung Cancer Cells”, Proceedings of the National Academy of Sciences of the United States of America, 108(28), 11332-11337. (SCIE)
C.-H. Hsu, S.-C. Hung, C.-Y. Wu, and C.-H. Wong, 2011, “Toward Automated Oligosaccharide Synthesis”, Angewandte Chemie-International Edition, 50(50), 11872-11923. (SCIE)
S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee, C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, 2010, “Glycan Array on Aluminum Oxide Coated Glass Slides Through Phosphonate Chemistry”, Journal of the American Chemical Society, 132(38),13371-13380. (SCIE)
M. Sawa, T.-L. Hsu, T. Itoh, M. Sugiyama, S. R. Hanson, P. K. Vogt, and C.-H. Wong, 2006, “Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo”, Proceedings of the National Academy of Sciences of the United States of America, 103(33), 12371-12376. (SCIE)
K. M. Koeller, C. H. Wong, 2001, “Enzymes for chemical synthesis”, Nature, 409, 232-240. (SCIE)
A. Heine, G. DeSantis, J. G. Luz, M. Mitchell, C. H. Wong and I. A. Wilson, 2001, “Observation of covalent intermediates in an enzyme mechanism at atomic resolution”, Science, 294, 369-374. (SCIE)
P. Sears, C. H. Wong, 2001, “Toward automated synthesis of oligosaccharides and glycoproteins”, Science, 291, 2344-2350. (SCIE)
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