Plant Proteolysis & Circadian Clock Lab

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    Protein degradation is critical for maintaining cellular protein homeostasis and therefore cellular functions.  Our laboratory mainly studies the protein degradation pathway mediated by the ubiquitin-proteasome system. In this process, E3 ubiquitin ligases bind to the protein to be degraded and mark them with ubiquitins. The ubiquitinated protein is then recognized and degraded by the 26S proteasome. In addition, some ubiquitinated proteins can bind to deubiquitinating enzymes to remove ubiquitins, which stabilizes the protein and prevents it from being degraded by the proteasome.

    The balance between ubiquitination and deubiquitination determines the protein level in cells and plays an extremely important role in regulating various biological pathways. Currently, our laboratory focuses on the molecular-level regulation mechanisms of ubiquitination in the plant circadian clock, high-temperature stress, and flowering regulatory pathways.
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(credit to Chih-Yen Tseng)

(credit to Jenny Chen)

 

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