Fetal ECG monitoring

Taking the challenge of fetal acidemia detection this to the bedside, my lab has developed a non-invasive approach to identify fetuses developing acidemia using multidimensional fetal HRV analyses with FDA-approved transabdominal fetal ECG (t-a fECG) monitors. Similarly, in fetal sheep model of inflammation, we showed that using such t-a fECG monitors we should be able to non-invasively detect systemic and gut fetal inflammatory response, even when it is clinically asymptomatic (no maternal signs of infection).

a. Frasch MG et al. (2014) Correlating multidimensional fetal heart rate variability analysis with acid-base balance at birth. Physiological Measurement. 35(12):L1-L12. PMID: 25407948.

b. Durosier LD, Herry CL, Cortes M, Cao M, Burns P, Desrochers A, Fecteau G, Seely AJ, Frasch MG. Does heart rate variability reflect the systemic inflammatory response in a fetal sheep model of lipopolysaccharide-induced sepsis? Physiol Meas. 2015;36(10):2089-102. PMID: 26290042.

c. L. Garzoni, H. Liu, L.D. Durosier, et al. Can Monitoring Fetal Intestinal Inflammation Using Heart Rate Variability Analysis Signal Incipient Necrotizing Enterocolitis of the Neonate? 2015. Pediatric Critical Care Medicine. 17(4):e165-76. DOI: 10.1097/PCC.0000000000000643. PMID: 26914621.

d. Herry CL, et al. Temporal patterns in sheep fetal heart rate variability correlate to systemic cytokine inflammatory response: a methodological exploration of monitoring potential using complex signals bioinformatics. 2016. PLoS One. 21;11(4):e0153515. DOI: 10.1371/journal.pone.0153515. PMID: 27100089.

e. Li R, Frasch MG, Wu HT. Efficient Fetal-Maternal ECG Signal Separation from Two Channel Maternal Abdominal ECG via Diffusion-Based Channel Selection. Front Physiol. 2017. 8:277. doi: 10.3389/fphys.2017.00277.

f. C Shen, MG Frasch, HT Wu, CL Herry, M Cao, A Desrochers, G Fecteau, P Burns. Non-invasive acquisition of fetal ECG from the maternal thorax: a feasibility study and a call for open data sets. arXiv:1708.09526 [physics.med-ph]

-> Dataset from this publication can be found here.