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Therapeutic uses
Therapeutic uses
Lipid lowering therapy
Lipid lowering therapy
Prevention of atherosclerotic disease
Prevention of atherosclerotic disease
Lipid-lowering therapies are given to anyone with existing atherosclerotic disease and anyone who is at risk of developing it.
Primary prevention of CVD
Primary prevention of CVD
- Anyone with a 10-year cardiovascular event risk of ≥10% (calculate using Q-risk tool).
- Anyone with T1DM (who is over 40 or was diagnosed >10 years ago OR has diabetic nephropathy)
- Anyone with CKD with an eGFR <60.
- Anyone with familial hypercholesterolaemia.
Typically, atorvastatin 20mg ON is prescribed initially, if non-HDL cholesterol has not fallen by >40%, consider titrating up to 80mg.
Secondary prevention of CVD
Secondary prevention of CVD
- Anyone who has had previous stroke/TIA.
- Anyone who has had angina or previous ACS.
- Anyone who has had peripheral arterial disease.
ATORVASTATIN 80mg ON is prescribed initially, if tolerated.
When should statins be taken?
When should statins be taken?
Statins should be taken before bed as cholesterol synthesis occurs predominantly at night, therefore statins will have greatest effect when given overnight. This is especially true for simvastatin which has a short half-life (3 hours)
Statins generally have a half-life of 1-3 hours with the exception of atorvastatin which is 14 hours.
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